Aha ngwaahịa:YDL223C (HBT1) ntụ ntụ

Aha ọzọ:HBT1,YDL223C

CASNo:489408-02-8

Nkọwapụta:99.0%

Agba:Agba odo siri ikena njirimara isi na uto

GMOỌnọdụ: GMO efu

Mbukota: na 25kgs fiber drum

Nchekwa: Debe akpa na-emegheghị n'ebe dị jụụ, ebe kpọrọ nkụ, zere ọkụ siri ike

Ndụ shelf: ọnwa 24 site na ụbọchị mmepụta

HBT1 bụ molekul nwere ike jikọta naanị na saịtị akọwapụtara na protein AMPA-R mgbe glutamate dị, njikọ a na-enyere aka ịhazi ọrụ nke protein. A na-egosipụta ndị na-anabata AMPA n'ime usoro nhụjuanya etiti ma na-arụ ọrụ dị mkpa na nkwurịta okwu neuronal, nhazi mmetụta, mmụta, ebe nchekwa, na synapti plasticity. Ndị na-anabata AMPA bụ ndị na-enye aka na neurotransmission na-akpali akpali, na-agba ọsọ ngwa ngwa, na-eme ka agụụ na-agụ ngwa ngwa na ọtụtụ synapses, ma na-etinye aka na nzaghachi mbụ na glutamate na mpaghara synapti. A na-ejikọta ndị na-anabata AMPA na ndị na-anabata NMDA na synapses, na ọnụ ha na-akwalite usoro synapti plasticity gụnyere mmụta, ebe nchekwa, excitotoxicity, na neuroprotection. Ihe na-akpata ụbụrụ ụbụrụ (BDNF) bụ ihe na-akpata neurotrophic nke na-arụ ọrụ dị mkpa n'ịkwado na mgbasawanye nke neurons ma nwee mmetụta dị ike na ọtụtụ mmetụta na mmụba, ọdịiche, nlanarị na ọnwụ nke mkpụrụ ndụ na-adịghị ahụkebe na ndị na-abụghị neuronal. , onye modulator neurotransmitter nke na-enye aka na plasticity neuronal na mmụta na ebe nchekwa. Ya mere, ọ dị mkpa maka ahụike na ọdịmma nke usoro ụjọ ahụ.

Ọrụ:

1. Yist genomic knockout nje
   2. Shmoo n'ọnụ protein, mkpụrụ nke Hub1p ubiquitin-dị ka protein; mutant nwere nkwarụ maka nhazi amụma mating, si otú ahụ
   na-etinye aka na Hbt1p na morphogenesis cell polarized; HBT1 nwere paralog, YNL195C, nke sitere na ntugharị genome dum
   3. Tinyere na mpaghara ọgwụ.
   4. kwalite ọgụgụ isi.
   5. Mee ka ebe nchekwa dịkwuo elu na ike ịdabere.
   6. Kwalite ọkwa mkpali.
   7. Mee ka njikwa nke ụbụrụ cortical / subcortical usoro.
   8. Melite nghọta nghọta.
   9. Meziwanye ike ụbụrụ iji dozie nsogbu ma chebe ya pụọ ​​​​na kemịkal ọ bụla ma ọ bụ anụ ahụ.

Ngwa:

HBT1 bụ akwụkwọ ọgụgụ dị ike AMPA-R [alpha-amino-3-hydroxy-5-methyl-4-isoxazole-propionic acid (AMPA) onye na-anabata ya] nwere mmetụta agonist dị ala ma e jiri ya tụnyere LY451395 na OXP1, ọ na-ebute mmepụta nke ụbụrụ sitere na ụbụrụ. Ihe na-akpata neurotrophic (BDNF) ma na-egosipụta ntakịrị mmetụta agonist na neurons bụ isi. HBT1 na-ejikọta na ngalaba njikọ njikọ nke AMPA-R na glutamate dabere manner