Aha ngwaahịa:Lupeol ntụ ntụ98%

Isi mmalite nke ihe ọkụkụ: Mango, Acacia visco, Abronia villosa, kọfị Dandelion.

CASNo:545-47-1

Agba:Na-acha ọcha na-acha ọchantụ ntụ na njirimara isi na uto

Nkọwapụta:≥98% HPLC

GMOỌnọdụ: GMO efu

Mbukota: na 25kgs fiber drum

Nchekwa: Debe akpa na-emegheghị n'ebe dị jụụ, ebe kpọrọ nkụ, zere ọkụ siri ike

Ndụ shelf: ọnwa 24 site na ụbọchị mmepụta

Ọrụ ndu:

Lupeol (Clerodol; Monogynol B; Fagarasterol) bụ pentacyclic triterpenoid na-arụ ọrụ, nwere mgbochi oxidant, mgbochi mutagenic, mgbochi tumor na mgbochi mkpali ọrụ.Lupeol bụ ihe dị ikeandrogen receptor(AR) inhibitor na enwere ike iji ya mee iheọrịa kansanyocha, karịsịa prostateọrịa kansanke androgen-based phenotype (ADPC) na castration resistant phenotype (CRPC) [1].

Na Vitro Nyocha:

Lupeol bụ ihe mgbochi AR siri ike nke enwere ike ịmepụta dị ka ọgwụ nwere ike ịgwọ ọrịa cancer prostate mmadụ (CaP).Lupeol (10-50 μM) ọgwụgwọ maka 48 h mere ka nkwụsị nke na-adabere na-adabere na sel nke androgen-based phenotype (ADPC), ya bụ LAPC4 na LNCaP cell, na IC50 nke 15.9 na 17.3 μM, n'otu n'otu.Lupeol machibidokwara uto nke 22Rν_1 na IC50 nke 19.1 μM.Na mgbakwunye, Lupeol gbochiri uto nke mkpụrụ ndụ C4-2b na IC50 nke 25 μM.Lupeol nwere ikike igbochi uto nke mkpụrụ ndụ CaP nke ma ADPC na CRPC phenotypes.A maara Androgens na-akwalite uto nke mkpụrụ ndụ CaP site na ịgbalite AR[1]

Na nyocha Vivo:

Lupeol bụ ọgwụ dị irè nke nwere ike igbochi tumorigenicity nke mkpụrụ ndụ CaP na vivo.Mkpokọta serum PSA na-ekesa (nke zoro ezo site na mkpụrụ ndụ tumor) ka a tụrụ na njedebe nke ọmụmụ na ụbọchị 56. N'ụbọchị 56 post-implantation, a na-ahụ ọkwa PSA sitere na 11.95-12.79 ng / mL na ụmụ anụmanụ na-achịkwa nwere etuto LNCaP na C4-2b etuto ahụ, n'otu n'otu.Agbanyeghị, ndị otu Lupeol na-emeso gosipụtara ọkwa ọbara ọbara PSA belatara sitere na 4.25-7.09 ng/mL.Akpụkpọ anụ sitere n'anụmanụ ejiri Lupeol gwọọ ya gosipụtara ọkwa ọbara ọbara PSA belatara ma e jiri ya tụnyere njikwa[1]