Aha ngwaahịa: Celastrol nnukwu ntụ ntụ
Isi mmalite nke ihe ọkụkụ: Chineke Vine (Tripterygium wilfordii nko.f)
CASNo:34157-83-0
Agba: ntụ ntụ oroma kristal na-acha ọbara ọbara nwere isi na ụtọ njirimara
Nkọwapụta:≥98% HPLC
GMOỌnọdụ: GMO efu
Mbukota: na 25kgs fiber drum
Nchekwa: Debe akpa na-emegheghị n'ebe dị jụụ, ebe kpọrọ nkụ, zere ọkụ siri ike
Ndụ shelf: ọnwa 24 site na ụbọchị mmepụta
Celatrol ntụ ntụbụ ihe na-arụ ọrụ na Tripterygii Radix, nke bụ mgbọrọgwụ akọrọ na rhizome nke Chineke Vine.Enwere ụdị anọ na mkpokọta, ya bụTripterygium wilfordii Hook.f, Tripterygium hypoglaucum Hutch, Tripterygium regelii Sprague et Takeda, na Tripterygium forresti Dicls.
Diterpenoids: triptolide (cas no.38748-32-2), Tripdiolide (cas no.38647-10-8), wdg.
Triterpenoids: Celastrol (cas no.34157-83-0), Wilforlide A (cas no.84104-71-2), wdg.
Alkaloids: Wilforgine (cas no.37239-47-7), Wolverine (cas no.11088-09-8), wilforidine, wdg.
Tripterygium bụ pentazine triterpene dị na Tripterygium wilfordii.Ọ dị irè n'ịgwọ ọrịa ogbu na nkwonkwo.Triptolide na-egbochi proteasome na ihe nuklia Kb ịrụ ọrụ.
Celastrol (Tripterin) bụ onye na-egbochi proteasome nwere ọrụ mgbochi mkpali na antioxidant.Ọ na-akacha mma na-egbochi ọrụ chymotrypsin dị ka 20S proteasome nwere IC50 nke 2.5 μM.
Tripterine bụ ọgwụ antioxidant dị ike na mgbochi mkpali.Ọ bụ ihe mgbochi ọhụrụ HSP90 (na-akpaghasị mgbagwoju anya Hsp90 / Cdc37), nwere mmetụta mgbochi ọrịa cancer (anti-angiogenesis - na-egbochi vascular endothelial growth factor receptor expression);antioxidant (na-egbochi peroxidation lipid) na ọrụ mgbochi mkpali (na-egbochi mmepụta nke iNOS na cytokines mkpali)
BiologicalAihe omumu:
Celastrol (Tripterin) na-achịkwa basal na DNA-emebi ihe na-akpata FANCD2 monoubiquitination, na-esote mmebi protein.Ọgwụgwọ Celastrol na-ewepụ IR-induced G2 checkpoint ma na-akwalite mmebi DNA nke ọgwụ ICL kpatara na mmetụta mgbochi na mkpụrụ ndụ cancer akpa ume site na imebi FANCD2.Celastrol nwere mmetụta mgbochi dị ịrịba ama na apoptosis na-akpali akpali na sel DU145 emebere na vitro n'oge na usoro dabere na dose.Mmetụta ọrịa cancer prostate nke Celastrol bụ akụkụ site n'ịchịkwa ọkwa ọkwa nke ọwa hERG na sel DU145, na-atụ aro na Celastrol nwere ike ịbụ ọgwụ nwere ike igbochi ọrịa cancer prostate, yana usoro ya nwere ike ịbụ igbochi ọwa hERG.Celastrol na-akwalite colitis nnwale na ụmụ oke IL-10 site na igbochi ụzọ akara PI3K/Akt/mTOR na ịkwalite autophagy.Celastrol nwere ikike igbochi ọrụ cytochrome P450 ma nwee ike ịkpata mmekọrịta ahịhịa.Celastrol na-ebute apoptosis na mkpụrụ ndụ TNBC, na-atụ aro na apoptosis nwere ike ịgbazite site na mitochondrial dysfunction na ụzọ akara PI3K/Akt.Celastrol na-ebute apoptosis na autophagy site na ụzọ akara ROS/JNK.Celastrol na-egbochi ọnwụ dopaminergic neuron na ọrịa Parkinson site na ịgbalite apoptosis mitochondrial.
Ọrụ Celasttrol na chemosensitization nke ọrịa cancer:
Chemotherapy ka bụ isi nhọrọ ọgwụgwọ maka ndị ọrịa kansa.Otú ọ dị, a ghaghị ijikọta chemotherapy na ọgwụ ndị ọzọ iji belata mmetụta ọjọọ ma zere iguzogide ọgwụ.A na-eji ngwaahịa ndị sitere n'okike eme ihe dị ka ọgwụgwọ adjuvant yana nchikota yana usoro chemotherapy dị ugbu a iji kwalite ịdị irè ọgwụgwọ.Otu ihe atụ na-ekwe nkwa nke ọgwụ sitere n'okike dị otú ahụ bụ ogige triterpene a na-akpọ celastrol, nke nwere ike inwe nnukwu ikike maka iji ya mee ihe dị ka onye na-ahụ maka ọgwụ.N'ịbụ nke a chọpụtara site na Thunder God Vine, ọ na-achịkwa ọtụtụ mkpụrụ ndụ oncogenic dị ka NF-κB, topoisomerase II, Akt/mTOR, HSP90, STAT3, na Notch-1.Ndị a nwere ike iduga nzaghachi mgbochi mkpali, gbochie uto tumor na nlanarị, ma wepụ angiogenesis.Isiakwụkwọ a na-achịkọta nkenke ọrụ celastrol nwere ike dị ka chemosensitizer na usoro mkpụrụ ndụ ndị dị n'okpuru na-agbazi mmetụta chemosensitizing ya akọpụtara na ọrịa kansa dị iche iche.
