Nicotinamide mononucleotide nnukwu ntụ ntụ
Aha ngwaahịa:Nicotinamide mononucleotide ntụ ntụ
Ụdị okwu: NMNβ-Nicotinamide Mononucleotide, beta-Nicotinamide Mononucleotide.
Nọmba CAS: 1094-61-7
Nkọwapụta: 99% nkeji
Usoro ihe omimi: C11H15N2O8P
Ibu molekụla: 334.221 g/mol
ngwugwu: 1kg / akpa, 25kg / drum
Kedu ihe bụ Nicotinamide Mononucleotide?
Nicotinamide mononucleotide, nke akpọrọ NMN, nwere aha ndị a:
β-NMN, BETA-Nicotinamide Mononucleotide;
BETA-NMN;BETA-NICOTINAMIDE MONOUCLEOTIDE;
BETA-NICOTINAMIDE RIBOSE MONOPHOSPHATE;
NICOTINAMIDE-1-IUM-1-BETA-D-RIBOFURANOSIDE 5′-PHOSPHATE;NICOTINAMIDE RIBOTIDE;
NICOTINAMIDE MONONUCLEOTIDE
NMN dị n'ime ihe dị iche iche gụnyere mmadụ ma bụrụ ihe dị mkpa maka ijikwa ọrụ anụ ahụ.A na-eji NMN mee ihe ọzọ mgbe ahụ megharịrị ya, vitamin B3 na nri nwekwara ike ịmepụta NMN.
Tupu anyị aghọta nicotinamide mononucleotide, anyị kwesịrị ịma ihe ọ bụ.Nicotinamide mononucleotide (NMN) bụ ihe mmalite dị mkpa nke NAD +, yana NAD + bụ ụzọ dị mkpa isi edozi mkpụrụ ndụ n'ime mmadụ.Mgbe ụmụ mmadụ nọ na ụmụ ọhụrụ na ụmụntakịrị, uto na mmepe ha na-adị ngwa ngwa, na mmụba nke afọ, ọrụ ahụ mmadụ ga-eji nwayọọ nwayọọ daa.Ihe atụ dị mfe dị ka nke ochie;ị ga-ekpu ìsì site na mberede.A kụturu ihe ndị ahụ, ma nke kadị njọ, e merụrụ ha ahụ́ nke ukwuu.N'ime usoro ịka nká nke mkpụrụ ndụ mmadụ, ọnụọgụ NAD + ga-ebelata nke ukwuu ma e jiri ya tụnyere oge gara aga n'ihi metabolism na ahụ n'onwe ya.
Nicotinamide mononucleotide bụ akụkụ dị mkpa nke ntughari mmadụ.Ndị ọkà mmụta sayensị gburugburu ụwa achọpụtala na nicotinamide mononucleotide nwere mmetụta ụfọdụ na ịka nká.N'ime nyocha miri emi, isi ihe dị na nicotinamide mononucleotide bụ na ọ bụ ihe mmalite nke NAD +, nke ga-agbanwe maka NAD +, gbakwunye ihe na-edozi cell na sel mmadụ, guzogide usoro ịka nká, ma nwee ohere ịmaliteghachi ọrụ ịmaliteghachi na. cell, nke bụ ọrụ ndọtị ndụ nke nicotinamide mononucleotide.
Nicotinamide mononucleotide na-adị na sel ọ bụla nke ahụ anyị ma bụrụ akụkụ dị mkpa nke nrụzi ahụ nke onwe ya.Ọ bụ metabolite maka idowe NAD + biosynthesis nkịtị, ihe a nwere ike ịhazi physiology n'oge mgbasa nke ahụ, yana na pathology akọwapụtara.Ọ na-arụ ọrụ dị mkpa na ọrụ cell.
Mmeju nwere NMN
Enwere ọtụtụ ngwaahịa mgbakwunye NMN na-ere ugbu a.Ụfọdụ na-ewu ewu n'etiti ndị ọrụ njedebe, dị ka NMN Pure, Ultra NMN, wdg na Amazon na ụlọ ahịa ndị ọzọ dị n'ịntanetị.
Ụfọdụ usoro dị na naanị NNN n'ime ya, ụfọdụ na-ejikọta ya na ihe ndị ọzọ na-eme ihe na-egbochi ịka nká, dị ka resveratrol, pterostilbene, gosipụtara mgbọrọgwụ mgbọrọgwụ, wdg.
Ma ụdị capsule na mbadamba ihe dị, n'okpuru bụ ụfọdụ NMN mgbakwụnye eziokwu sitere na ụfọdụ akara NMN:
125mg yiri ka ọ bụ usoro ọgwụgwọ na-ewu ewu maka ọtụtụ ihe mgbakwunye NMN, ọ bụ ezie na ụfọdụ na-ede 260mg kwa capsule na akara ha na nha nke 2 capsules ma ọ bụ mbadamba kwa ụbọchị.Ọnweghị usoro ọgwụgwọ gọọmentị akwadoro ugbu a.
Usoro ọrụ nke nicotinamide mononucleotide
A na-atụgharị nicotinamide mononucleotide ka ọ bụrụ “nicotinamide adenine dinucleotide (NAD)” ihe dị mkpa maka metabolism ike n'ime ahụ.N'ime nnwale òké, a kwadoro na nicotinamide mononucleotide nwere ike ime ka mkpụrụ ndụ ihe nketa a na-akpọ acetylase rụọ ọrụ n'ime ahụ, si otú ahụ na-enwe mmetụta dị ka ịgbatị ndụ na ọgwụgwọ ọrịa shuga.NAD bụ ihe nke ahụ mmadụ nwere ike imepụta.Nnyocha egosiwo na ọdịnaya NAD na ahụ na-ebelata ka afọ.
Mmụba nke mbufụt metụtara ịka nká nwere ike imebi ikike ahụ imepụta NMN, nke na-ebute mbelata NAD.
NMN bụ ihe mmalite nke coenzyme NAD + dị oke egwu n'ime ahụ.Nicotinamide mononucleotide bụ ọrụ dị mkpa na mmepụta ike cell mmadụ, ọ na-etinyekwa aka na njikọ nke intracellular NAD + (nicotinamide adenine dinucleotide, coenzyme maka ntụgharị ike cell).
A nabatara NMN n'ihu ọha dị ka ihe okike izizi nke ụwa gosipụtara site na nnwale sayensị siri ike iji tụgharịa na igbu oge ịka nká nke ọma na ogologo ndụ.
Na 2017, ọmụmụ egosila na NMN nwere ike ịgwọ NR na NMN ataxia, na NR adịghị agbanwe ọrụ SIRT3 ma ọ bụ melite ọrụ obi.
NAD + ọkọnọ agaghị akwụsị - ọ ga-anọgide na-eri ya ma mejupụta ya, na ọdọ mmiri NAD + dum na-atụgharị ugboro 2-4 n'ụbọchị.
Usoro a sitere na ụzọ mgbazigharị, nke enzyme Nampt na-eme ka NAM gaa NMN wee metabolize gaa na NAD +.Nampt bụ njedebe ọsọ ọsọ na usoro ịkụ azụ.
Nicotinamide Mononucleotide VS.Nicotinamide riboside
N'oge a, ụwa bara ụba na nyocha dị iche iche na NR, na nnwale nke ahụ mmadụ na-eme ka nsonaazụ NR na data usoro ihe dị mma karịa NMN.Otú ọ dị, ọmụmụ egosiwo na NR na-amalite ịrụ ọrụ n'ime ahụ mmadụ ma ka na-enwekwa ahụmahụ ruo oge ụfọdụ.Isi ihe bụ na ma NR na NMN bụ ihe mmalite nke NAD +, ebe Nicotinamide Riboside (NR) bụ ihe mmalite nke NMN na NAD +, ya mere NR na-agbanwe.Ọ na-ewe oge tupu NAD +.E jiri ya tụnyere mmetụta ozugbo nke NMN, nkeji iri na ise nke NR bụ nnukwu oghere.
Enwere ike ịhụ site na eserese okirikiri dị n'elu na NAMPT bụ ihe dị mkpa na-egbochi ọgbọ NMN.Ka afọ na-abawanye, ọ bụghị ahụ mmadụ achọghị ịbụ nwata, mana ọrụ enzyme nke NAMPT na-ebelata mgbe a na-enye ike na nri.Ka usoro NAM na-ebelata, ngwaahịa NAD + na-ebelata nke ọma.
Enwere ike ịtụgharị NR ka ọ bụrụ NMN ma ọ bụ na NAM, dabere na ọrụ Nrk1 enzyme iji chọpụta ihe nke otu àgwà NR ga-emepụta karịa.Ọ bụrụ na agbanwere ya ka ọ bụrụ NAM, enzyme NAMPT machibido ya.E jiri ya tụnyere omume NMN kpọmkwem iji mepụta NAD +, mmetụta nke nha nha nha nke NR na-ebelata nke ukwuu.
Gịnị kpatara na ị gaghị ewere NAD+?
Enweghị ike ibuba NAD+ n'ime sel ozugbo site na nchịkwa ọnụ n'ihi oke molekul ya.A na-enweta mgbakwunye NAD + naanị site n'inweta obere ihe dị arọ NAD + precursor.
Agbanyeghị, enwere ike ịme NMN ka ọ bụrụ ngwaahịa dị iche iche, nke nwere ike ịbụ capsules, mbadamba, ma ọ bụ ọbụna granules n'ihi ọdịdị soluble ya.Solubility nke NMN na mmiri bụ 35mg / ml.
N'echiche a, NMN dị mma karịa NAD +, yana karịa nicotinamide riboside.
Nicotinamide Mononucleotide bara uru
Isi mmetụta nke NMN bụ ndị a:
- mgbochi oxidation
- Weghachite ọdịda physiological
- Ndozi DNA
- Na-akwado mmetụta neuroprotective
- Melite ọrụ obi ma chebe obi
- Melite ọkwa nke ndị ọrịa Alzheimer
Akụkụ pụrụ iche nke NMN bụ na ọ nwere ike gbanwee ịka nká na ogologo ndụ.
Mmetụta mmetụta Nicotinamide Mononucleotide
Ebe ọ bụ na NMN na-eme ugbu a naanị nyocha anụmanụ, nnukwu ọnwụnwa mmadụ amalitebeghị, ya mere mmetụta ndị nwere ike ikpebi ka edoghị anya.Otú ọ dị, dị ka usoro ọrụ nke NMN si dị, enwere ike ịpụta na ndị ọrịa cancer agaghị ewere ya dị ka o kwere mee.N'ihi na mgbanwe NMN na-akwalite mmepụta nke NAD +, ebe mkpụrụ ndụ cancer na-eme mgbanwe iji nwayọọ nwayọọ na-eme ihe omume anụ ahụ, mmụba nke metabolism nwere ike ịkpalite mgbasa nke ụfọdụ mkpụrụ ndụ kansa.
Mgbe ị na-eji ihe mgbakwunye nicotinamide nucleoside dị ka NMN, arụmọrụ mmega ahụ nwere ike imetụta.N'ime ụmụ oke, ụmụ oke etinyere na mgbakwunye NAD+ gosipụtara arụmọrụ dị obere karịa otu njikwa ha.
