Aha ngwaahịa:Nicotinamide riboside chloride ntụ ntụ
Aha ndị ọzọ: 3- (Aminocarbonyl) -1-PD-ribofuranosyl-pyridinium chloride (1: 1); Nicotinamide
Riboside.Cl;3-Carbamoyl-1-beta-D-ribofuranosyl-pyridinium chloride;NR, vitamin NR;Niagen, TRU NIAGEN
CASNO: 23111-00-4
Usoro ihe omimi: C11H15N2O5.Cl
Arọ molekụla: 90.70 g/mol
Ịdị ọcha: 98%
Ebe mgbaze: 115 ℃-125 ℃
Ọdịdị: Gbanyụọ ọcha ruo ntụ ntụ edo edo na-acha odo odo
Jiri: Na-akwalite ọkwa NAD +, na-akwado ịka nká na ụbụrụ / ọgụgụ isi
Ngwa: dị ka ihe mgbakwunye nri, nri na-arụ ọrụ, na ihe ọṅụṅụ
Usoro ọgwụgwọ akwadoro: ọ bụghị ihe karịrị 180 mg / ụbọchị
Nicotinamide riboside bụ ụdị vitamin B3 enwetara ọhụrụ, nwere ihe pụrụ iche;Ọ bụ ihe mmalite nke NAD +.
Nicotinamide riboside (NR), nke mbụ kọwara na 1944 dị ka ihe na-eto eto (Factor V) maka Haemophilus influenza, na na 1951, NR, nyochara nke mbụ dị ka njedebe metabolic na anụ ahụ mammalian.
Dịka ị nwere ike ịhụ nke ahụ, enwere ụdị NR abụọ dị, otu bụ Nicotinamide Riboside, nke ọzọ bụ Nicotinamide Riboside chloride.
N'ikwu okwu kemịkalụ, ha bụ ogige abụọ dị iche kpamkpam ebe ha nwere ọnụọgụ CAS dị iche iche, NR nwere 1341-23-7 ebe NR chloride nwere 23111-00-4.NR anaghị eguzosi ike na ụlọ okpomọkụ, ebe NR chloride kwụsiri ike.Brand ama ama ama ama ama aha ya bụ NIAGEN®, nke Chromadex Inc wepụtara na 2013, bụ ụdị Nicotinamide riboside chloride, na-achọ ịgbanwe akara nke ịka nká n'ime ahụ gị.Nicotinamide Riboside emepụtara site na Cima Science dịkwa n'ụdị ntụ ntụ chloride.Ọ bụrụ na akọwaghị ya, NR ga-ezo aka na ụdị NR chloride n'ime akụkọ dị n'okpuru.
Nicotinamide riboside isi mmalite nri
Ọnụ ego NR na nri bụ nkeji, ma e jiri ya tụnyere nke ahụ na mgbakwunye nri.Agbanyeghị, kedu isi mmalite nri nwere nicotinamide riboside (NR)?
Mmiri ara ehi
Mmiri ara ehi na-enwekarị ∼12 μmol NAD(+) vitamin/L precursor, nke 60% dị ka nicotinamide, na 40% dị ugbu a dị ka NR.(mmiri ara ehi a na-ahụkarị nwere NR karịa mmiri ara ehi organic), ọmụmụ nke Mahadum Iowa bipụtara, na 2016
Yist
Otu nnyocha e mere ochie ekwuola, "Otu ihe mgbochi dịpụrụ adịpụ na yist ma chọpụta na ọ bụ nicotinamide riboside, ọ nwere ike ịbụ site na NAD (P) n'oge nkwadebe nke yist wepụ, ma ọ bụ site na ihe mgbakwunye ihe oriri na-edozi ahụ n'oge mgbaze na vivo."Ọ bụ ezie na enweghị ọnụọgụ ọnụọgụ na yist
Biya
Bia nwere oke carbs na ị drinkụ ndị dị n'ụdị mmiri mmiri dị otú ahụ ga-enwe mmetụta glycemic;akwụkwọ nyocha dị iche iche ekwuola biya dị ka isi nri nke nicotinamide riboside.
Ọzọkwa, enwere ike ịnwe ọnụọgụ NR dị ka protein whey, olu, wdg.
Nye ọtụtụ ndị mmadụ, mmiri ara ehi na-egbochi oke maka ihe ndị ọzọ.Isi mmalite nri nke nicotinamide riboside nwere ike ịba uru, mana ha adịghị arụ ọrụ karịa mgbakwunye NR.
Kedu ihe kpatara Nicotinamide Riboside (NR) jiri kọwaa dị ka ezigbo NAD + precursor vitamin invertebrates?
Enwere usoro echiche ise na-akwado ya:
Haemophilus influenza, nje na-akpata flu, nke na-enweghị ụzọ de novo na enweghị ike iji Na ma ọ bụ Nam, dabere na NR, NMN, ma ọ bụ NAD+ maka itolite n'ọbara ndị ọbịa.
Mmiri ara ehi bụ isi iyi nke NR.
NR na-echebe neurons DRG murine na ex vivo axonopathy assay site na ntinye ederede nke nicotinamide riboside kinase (NRK) 2 gene.
NR agbakwunyere na ihe nrụpụta na-abawanye mkpokọta NAD + n'ụdị dabere na dose na ahịrị sel mmadụ.
Candida glabrata, ero nwere ohere nke dabere na NAD + precursor vitamin maka uto, na-eji NR n'oge ọrịa na-ekesa.
Nicotinamide Riboside VS Nicotinamide VS Niacin
Niacin (ma ọ bụ nicotinic acid), bụ ngwakọta organic na ụdị vitamin B3, ihe na-edozi ahụ mmadụ.Ọ nwere usoro C6H5NO2.
Nicotinamide ma ọ bụ nke a na-akpọ niacinamide bụ ụdị vitamin B3 dị na nri ma jiri ya mee ihe dị ka ihe mgbakwunye nri na ọgwụ.Ọ nwere usoro C6H6N2O.
Nicotinamide riboside bụ pyridine-nucleoside ụdị vitamin B3 nke na-arụ ọrụ dị ka ihe na-ebute nicotinamide adenine dinucleotide ma ọ bụ NAD +.Ọ nwere usoro C11H15N2O5+.
Abamuru ahụike Nicotinamide Riboside
Nicotinamide Riboside na-enyere aka ịmepụta ike
N'ime anụmanụ, NR supplementation belatara oriri NAD, nke mere ka ọrụ mitochondrial dịkwuo mma, na-eweghachite anụ ahụ ngwa ngwa, na-echekwa ike NAD ọkwa na mmega ahụ n'ime ụmụ oke ndị toro eto, na-enyere aka ịnọgide na-enwe ahụ ike na ọrụ, na-akwado ike ike.
Nicotinamide Riboside na-eme ka ọrụ ọgụgụ isi dịkwuo mma
NR na-echekwa mkpụrụ ndụ akwara na ụbụrụ site na ịgbalite SIRT3, Mgbakwunye na-akpali ụzọ NAD ma na-enyere aka gbochie mmebi n'uche.
NR kwalitere ọrụ ọgụgụ isi wee kwụsịlata ọganihu nke ọrịa Alzheimer na ụmụ oke enyere NR ọnwa atọ.
Nicotinamide Riboside na-egbochi ịnụ ntị
Site n'ime ka ụzọ SIRT3 rụọ ọrụ, nchọpụta UNC chọpụtara na ọ nyere aka chekwaba òké ka ọ ghara ịnụ mkpọtụ na-akpata.
Nicotinamide Riboside na-echebe imeju
Were NR ọnụ ọnụ na-abawanye NAD n'ime ahụ, nke na-enyere aka ichebe imeju.NR kwụsịrị ịchịkọta abụba, belata nrụgide oxidative, gbochie mbufụt, yana mmụba insulin n'ime imeju ụmụ oke.
Ọzọkwa, NR nwere ike ịgbatị ogologo ndụ, Na-abawanye metabolism, na-akwado ọgụ megide ọrịa kansa, belata mgbaàmà ọrịa shuga, na-abawanye metabolism, nwere ike inye aka na ọnwụ.
Nicotinamide Riboside ọ dị mma?
Ee, NR adịghị mma.
NR nwere nnwale ụlọ ọgwụ atọ ebipụtara na-akwado na ọ dị mma maka oriri mmadụ.
Iji nlezianya nyochaa na mesie ike na ozi gbasara ahụike na ahụike dị na NR na-eme ka obi sie gị ike na ọ dị mma ma nabata ya nke ọma.
Niagen dị mma na GRAS, na-eji usoro sayensị, n'okpuru Iwu Federal Food, Drug, and Cosmetic Act (FFDCA).
Nicotinamide Riboside Ọnwụnwa mmadụ
Enwere ọtụtụ ọmụmụ tupu ụlọ ọgwụ emerela nnwale NR na sistemu ụdị dị iche iche.
N'afọ 2015, ọmụmụ ụlọ ọgwụ mmadụ mbụ mechara, nsonaazụ ya gosipụtara na NR na-akwalite ọkwa NAD nke ọma na ndị ọrụ afọ ofufo ahụike.
Nnwale ụlọ ọgwụ na-achịkwa placebo nke nicotinamide riboside n'ime ụmụ nwoke buru oke ibu site na enweghị usoro: nchekwa, mmetụta insulin na mmetụta na-akpali akpali.
– Ebipụtara ya na American/Journal of Clinical Nutrition
Nsonaazụ: 12 wk nke NR supplementation na doses nke 2000 mg/d na-egosi na ọ dị mma, mana ọ naghị eme ka mmetụta insulin dịkwuo elu na metabolism nke glucose na-arụ ọrụ na oke ibu, ụmụ nwoke na-eguzogide insulin.
Nicotinamide riboside supplementation na-anabata nke ọma ma na-ebuli NAD + na ndị agadi nọ n'etiti na ndị okenye ahụike.
-Ebipụtara ya na Nkwukọrịta Nature
Nicotinamide Riboside bụ Karịsịa na Oral Bioailable na ụmụ oke na ụmụ mmadụ
-Ebipụtara ya na Nkwukọrịta Nature
N'ebe a, anyị na-akọwa oge na mmetụta dabere dose nke NR na ọbara NAD metabolism n'ime mmadụ.Nkwupụta ahụ na-egosi na NAD ọbara mmadụ nwere ike ibili ihe ruru okpukpu 2.7 site na otu ọnụọgụ ọnụ nke NR na nyocha nyocha nke otu onye na NR nke ọnụ na-ebuli NAD hepatic òké dị elu na ọgwụ dị elu.
