Oleoylethanolamide (OEA)

Aha ngwaahịa:Oleoylethanolamide, N-Oleoylethanolamide, OEA
Aha ọzọ:N- (2-Hydroxyethyl) -9-Z-octadecenamide, N-oleoyl ethanolamide, Oleoyl monoethanolamide, 9-Octadecenamide, N- (2-Hydroxyethyl)oleamide.
CAS Mba:111-58-0
Ụdị Molecular:C₂₀H₃₉NO₂
Ibu Molecular:325.5
Nyocha:90%,95%, 85% min
Ọdịdị:ntụ ntụ na-acha ude

Oleoylethanolamidebụ ihe ọhụrụ na nutritional ahịa dị ka a na-ewu ewu dietary emeju ingredient eji na arọ ọnwụ formulas.Ọtụtụ ndị na-akwado ahụ na-ekwurịta banyere oleoylethanolamide na reddit na nyiwe ịkparịta ụka n'Ịntanet ndị ọzọ.

Oleoylethanolamide bụ metabolite ebumpụta ụwa nke oleic acid emere n'ime eriri afọ dị n'ime ahụ mmadụ.Ọ na-emekarị, ndị ọkachamara na-akpọ ya "endogenous".

OEA bụ onye na-achịkwa agụụ, ibu na cholesterol.Ọ bụ metabolite ebumpụta ụwa nke a na-eme na obere ntakịrị n'ime obere eriri afọ gị.OEA na-enyere aka ịhazi agụụ, ibu, abụba anụ ahụ na cholesterol site na ijikọ na onye na-anabata ihe a maara dị ka PPAR-Alpha (Peroxisome proliferator-activated receptor alpha).N'ezie, OEA na-abawanye metabolism nke abụba anụ ahụ ma na-agwa ụbụrụ gị na afọ juru gị afọ na oge eruola ịkwụsị iri nri.A makwaara OEA ka ọ na-abawanye mmefu kalori na-abụghị mmega ahụ.

Akụkọ ihe mere eme nke Oleylethanolamide

Achọpụtara ọrụ ndụ Oleoylethanolamide n'oge dị ka afọ 50 gara aga.Tupu 2001, ọnweghị ọtụtụ nyocha na OEA.Otú ọ dị, n'afọ ahụ, ndị na-eme nchọpụta Spanish mebiri egbugbere ọnụ ma mụọ otú e si emepụta ya, ebe a na-eji ya na ihe ọ na-eme.Ha nwalere mmetụta OEA na ụbụrụ (nke oke) site n'itinye ya ozugbo na ventricles ụbụrụ.Ha ahụghị mmetụta ọ bụla na iri nri ma kwenye na OEA adịghị eme na ụbụrụ, kama ọ na-ebute mgbaàmà dị iche iche nke na-emetụta agụụ na omume iri nri.

Oleylethanolamide VS cannabinoid anandamide

Ebu ụzọ mụọ mmetụta nke OEA n'ihi na ọ na-ekerịta myirịta na kemịkalụ ọzọ, cannabinoid a maara dị ka anandamide.Cannabinoids metụtara osisi Cannabis, anandamides dị na osisi (na wii wii) nwere ike ịbawanye agụụ mmadụ iri nri site na ịkpalite nzaghachi nri.Dabere na Wikipedia, Oleoylethanolamide bụ analog monounsaturated nke endocannabinoid anandamide.Ọ bụ ezie na OEA nwere usoro kemịkalụ nke yiri anandamide, mmetụta ya na iri nri na njikwa ibu dị iche.N'adịghị ka anandamide, OEA na-eme n'adabereghị na ụzọ cannabinoid, na-achịkwa ọrụ PPAR-α iji kpalie lipolysis.

Ọdịdị nke ethanolamides fatty-acid dị iche iche: oleoylethanolamide (OEA), palmitoylethanolamide (PEA) na anandamide (arachidonoylethanolamide, AEA).(Cima Science Co., Ltd bụ naanị onye na-emepụta nnukwu akụrụngwa nke OEA, PEA na AEA na China, ọ bụrụ na ịchọrọ nlele na ọnụahịa ọnụahịa, biko hapụ anyị email na ibe ịkpọtụrụ anyị.)

OEA na-ejikọta ya na njikọ dị elu na peroxisome-proliferator-activated receptor-a (PPAR-a), onye na-anabata nuklia nke na-achịkwa ọtụtụ akụkụ nke metabolism lipid.

Oleoylethanolamide sitere n'okike

Oleoylethanolamide bụ metabolite eke nke oleic acid.Ya mere, nri nwere oleic acid bụ isi iyi nke OEA.

Oleic acid bụ abụba bụ isi na mmanụ ihe oriri dị ka oliv, canola na sunflower.Oleic acid nwekwara ike ịhụ na mmanụ nut, anụ, anụ ọkụkọ, cheese, wdg.

Isi nri nri bara ụba na oleic acid gụnyere: Mmanụ Canola, Mmanụ oliv, mmanụ ube oyibo, mmanụ almond, ube oyibo, mmanụ Safflower High Oleic.

Ụfọdụ eziokwu gbasara Oleic Acid:

Otu n'ime abụba ndị a na-ahụkarị na mmiri ara ara mmadụ

Na-eme 25% abụba n'ime mmiri ara ehi

Monounsaturated

Omega-9 fatty acid

Usoro kemịkal bụ C18H34O2(CAS 112-80-1)

A na-etinye ya na triglycerides

A na-eji ihe ịchọ mma dị ọnụ ahịa dị elu dị ka mmiri mmiri dị irè

Achọtara ya na abụba mmiri ara ehi, cheese, mmanụ oliv, mmanụ grapeseed, mkpụrụ, ube oyibo, akwa na anụ

Nwere ike bụrụ onye na-ahụ maka ọtụtụ uru ahụike mmanụ oliv!

Na-emepụta ogige ndị dike nwere protein mmiri ara ehi ndị ọzọ iji lụso mkpụrụ ndụ kansa ọgụ

Uru Oleoylethanolamide

Oleoylethanolamide (OEA) dị mma ịkwụsị ibu dị ka onye na-achịkwa agụụ ma na-akwado ọkwa cholesterol dị mma na ndị okenye.

OEA dị ka onye na-egbochi agụụ

Mbelata agụụ bụ isi ihe na-achịkwa oriri ume (nri), ijikwa agụụ dị mkpa n'ịchịkwa oke ahụ dị mma.Kedu ka OEA si ejikwa agụụ gị?Ị nwere ike ịlele usoro omume n'okpuru.

OEA na cholesterol

Mmanụ oliv bụ kpakpando na-edozi ahụ, ma na-enyere aka belata LDL cholesterol "ọjọọ" ma mụbaa HDL "dị mma".Gịnị kpatara?Ihe ruru pasenti 85 nke mmanụ oliv bụ oleic acid, yana metabolite bụ isi nke oleic acid bụ OEA (Oleoylethanolamide bụ aha zuru oke).Ya mere, obi abụọ adịghị ya na OEA na-enyere aka mee ka cholesterol dị mma.

Ụfọdụ nyochagharị na-egosi na oleoylethanolamide nwere mmetụta dị mma na nchekasị, yana ọtụtụ ụzọ na ihe akaebe dị mkpa iji kwado.

Usoro mmepụta nke Oleoylethanolamide

Oleoylethanolamide na-asọpụta dị n'okpuru:

Usoro n'ozuzu bụ: mmeghachi omume → Usoro nchacha → Filtration → Na-agbazekwa na ethanol →hydrogenation → Filtrate Clear Liquid→crystalization → Filtration → Testing→ Packing → Ọgwụgwụ ngwaahịa

Usoro ọrụ nke oleoylethanolamide

N'ikwu ya n'ụzọ dị mfe, oleoylethanolamide na-arụ ọrụ dị ka onye na-achịkwa agụụ.OEA nwere ike ijikwa ihe oriri gị site n'ịgwa ụbụrụ na anụ ahụ jupụtara, na ọ dịghị nri ọzọ achọrọ.Ị na-eri obere nri kwa ụbọchị, na ahụ gị nwere ike ghara ibu ibu n'ikpeazụ.

Omume mgbochi oke ibu nke oleoylethanolamide (OEA) ka egosiri na foto a.A na-ahazi OEA ma chịkọta ya na eriri afọ dị nso site na oleic acid nke enwetara nri, dị ka mmanụ oliv.Nri nwere oke abụba nwere ike igbochi mmepụta OEA n'ime eriri afọ.OEA na-ebelata oriri nri site na ịgbalite homeostatic oxytocin na histamine ụbụrụ sekit yana ụzọ hedonic dopamine.Enwere ihe akaebe na OEA nwekwara ike belata hedonic cannabinoid receptor 1 (CB1R) na-egosi, ntinye ya na-ejikọta ya na oriri na-abawanye.OEA na-ebelata ibufe lipid n'ime adipocytes iji belata oke abụba.Nkọwa ọzọ nke mmetụta nke OEA na oriri nri na metabolism lipid ga-enyere aka na mkpebi siri ike nke usoro ahụike nke enwere ike ịchebe ịzụlite usoro ọgwụgwọ oke ibu dị irè karị.

OEA na-arụ ọrụ iji mee ka ihe a na-akpọ PPAR rụọ ọrụ ma na-ebuli abụba na-ere ọkụ ma na-ebelata nchekwa abụba.Mgbe ị na-eri nri, ọkwa OEA na-abawanye ma agụụ gị na-ebelata mgbe irighiri akwara na-ejikọta na ụbụrụ gị na-agwa ya na afọ juru gị.PPAR-α bụ otu nke ligand-activated nuclear receptor nke na-etinye aka na mkpụrụ ndụ okwu nke metabolism lipid na ume homeostasis ụzọ.

OEA na-egosi njirimara niile nke ihe satiety:

(1) Ọ na-egbochi inye nri site n'ịgbatị ogologo oge na nri ọzọ;

(2) A na-ahazi nhazi ya site na ịnweta nri na

(3) Ọkwa ya na-enwe mgbanwe circadian.

Mmetụta mmetụta Oleoylethanolamide

Nchekwa Oleoylethanolamide bụ nnukwu nchegbu n'etiti ụdị mgbakwunye ndị chọrọ ịnwale ihe ọhụrụ a na usoro ịbelata ibu ha.

Mgbe nyochachara akwụkwọ na data niile dị, US Food and Drug Administration (FDA) enweghị nchegbu gbasara nchekwa OEA.RiduZone bụ ihe izizi oleoylethanolamide ntụ ntụ akpọrọ kemgbe 2015.

Oleoylethanolamide bụ metabolite nke oleic acid, nke bụ akụkụ nke nri dị mma kwa ụbọchị.Ọ dị mma ịnwale mgbakwunye OEA, ọ nweghịkwa mmetụta ọjọọ a kọpụtara.

a kọwo mmetụta.

Oleoylethanolamide ọnwụnwa mmadụ

N'ime otu ọmụmụ, a gwara mmadụ iri ise (n = 50) ndị nwere mmasị na ịlalata ibu ka ha were OEA 2-3 ugboro / ụbọchị, 15-30 nkeji tupu nri maka izu 4-12.Isiokwu gụnyere ndị na-ejibeghị arọ ọnwụ ngwaahịa tupu, ndị nwetara adverse omume na ndị ọzọ arọ ọnwụ ngwaahịa, ndị na-atụ aro plateaued na ndị ọzọ arọ ọnwụ mmadụ dị ka phentermine, ndị na-agbalị mejuputa ụdị ndụ mgbanwe (akụkụ akara na mgbe mmega ahụ mgbe nile. ), na ndị a na-arụsi ọrụ ike maka ọnọdụ ahụike gụnyere enweghị nnabata glucose, dyslipidemia, ọbara mgbali elu na ọrịa obi.

N'ime ọmụmụ ihe nke abụọ, a gwara isiokwu 4 nwere ihe dị arọ nke 229, 242, 375 na 193 lbs ka ha were Oleoylethanolamide capsules (otu capsule nwere 200mg 90% OEA).Ndị mmadụ na-ewere capsules 4 (1 capsule 15-30 nkeji tupu nri, ha ga-ewerekwa capsule ọzọ tupu nri kacha ukwuu n'ụbọchị) kwa ụbọchị maka ụbọchị 28.Edemebula isiokwu ikpeazụ n'ọgbụgba ụkwụ ụkwụ.A gwara ndị nọ n'okpuru iwu ka ha ghara ime mgbanwe ọ bụla na nri ha na omume mmega ahụ.

Nsonaazụ

N'ime ọmụmụ ihe mbụ, isiokwu tụfuru nkezi 1-2 lbs / izu.Enweghị mmetụta ọ bụla ma e wezụga otu onye ọrịa na-enwe ọgbụgbọ na-agafe agafe nke edoziworo n'ime ihe na-erughị otu izu.N'ime ọmụmụ ihe nke abụọ, 3 n'ime isiokwu 4 kọrọ na oke ibu (3, 7, 15 na 0 lbs n'otu n'otu).Isiokwu 4 niile kọrọ mbelata 10-15% na nha akụkụ, ogologo oge n'etiti nri, na enweghị mmetụta ọ bụla.

Ọ bụrụ na ị nwere mmasị na akwụkwọ ndị ọzọ gbasara ọnwụnwa mmadụ na OEA, biko gaa na njikọ PDF ndị a na-ebudata.

Oleoylethanolamide usoro onunu ogwu

Enwere ntakịrị ozi nyocha gbasara mgbakwunye OEA ugbu a n'ime mmadụ, ebe a na-ewere ya dị ka nchekwa, enweghị usoro ọgwụgwọ akwadoro.Agbanyeghị, enwere ụfọdụ mgbakwunye na ahịa, ma ị nwere ike ịchọta ụfọdụ maka ntụaka gị.

Usoro ọgwụgwọ kwa ụbọchị nke RiduZone (akara OEA/Oleoylethanolamide 90%) bụ 200mg (1 Capsule nwere naanị OEA n'ime ya).Ọ bụrụ na agwakọta ya na ihe ndị ọzọ na-ebelata ibu arọ, dose ahụ kwa ụbọchị yiri ka ọ dị obere, kwuo 100mg ma ọ bụ 150mg.Ihe mgbakwunye ụfọdụ

A na-atụ aro ka ị were ihe mgbakwunye oleoylethanolamide nkeji 30 tupu nri ụtụtụ na nri abalị, ị ga-enwekwu afọ ojuju n'oge nri na n'ihi nke a ga-eri obere nri.

Akwụkwọ nyocha gbasara oleoylethanolamide

Oleoylethanolamide: onye ọkpụkpọ ọhụrụ na njikwa metabolism ike.Ọrụ na oriri nri

Oleoylethanolamide na-abawanye nkwupụta nke PPAR-Α ma na-ebelata agụụ na ibu ahụ na ndị buru ibu: nnwale ụlọ ọgwụ.

Molecules Brain na agụụ: Okwu Oleoylethanolamide

Oleylethanolamide na-achịkwa nri na ịdị arọ ahụ site na ịgbalite onye na-anabata ihe nuklia PPAR-a.

Ntinye nke TRPV1 site na Satiety Factor Oleoylethanolamide

Iwu oriri nke oleoylethanolamide

Usoro oleoylethanolamide na nnabata nke fatty acid n'ime obere eriri afọ mgbe iri nri na mbelata ibu ahụ.

Oleoylethanolamide: Ọrụ nke bioactive lipid amidein na-agbanwe omume iri nri

Oleoylethanolamide: Onye mmekọ abụba n'ọgụ megide oke ibu

Oleoylethanolamide: Ọdịnihu Pharmacological nwere ike ịbụ nke Cannabinoid na-emegide maka njikwa agụụ.