Sialic acid ntụ ntụ

Sialic acid (SA), nke sayensị maara dị ka "N-acetylneuraminic acid," bụ carbohydrate sitere n'okike.Ọ bụ na mbụ dịpụrụ adịpụ na submandibular gland mucin, ya mere aha ya.Sialic acid na-adịkarị n'ụdị oligosaccharides, glycolipids ma ọ bụ glycoproteins.N'ime ahụ mmadụ, ụbụrụ nwere sialic acid kachasị elu.Ọdịnaya sialic acid dị na ihe isi awọ ji okpukpu iri na ise karịa nke akụkụ ahụ dị n'ime dị ka imeju na ngụgụ.Isi nri nke sialic acid bụ mmiri ara ara, nke a na-ahụkwa na mmiri ara ehi, akwa na cheese.

Na ọgwụ, glycolipids nwere sialic acid ka a na-akpọ gangliosides, nke na-arụ ọrụ dị oke mkpa na mmepụta na mmepe nke ụbụrụ na usoro ụjọ.N'otu oge ahụ, ọmụmụ anụmanụ egosila na mbelata ọkwa nke ganglioside na-ejikọta ya na erighị ihe na-edozi ahụ n'oge na mbelata ikike mmụta, ebe mgbakwunye na sialic acid nwere ike imeziwanye omume mmụta anụmanụ.Ịnweta sialic acid zuru oke nwere ike ịdị mkpa karịsịa maka mmepe nkịtị nke ọrụ ụbụrụ n'ime ụmụaka nwere obere ọmụmụ.Mgbe a mụsịrị nwa, sialic acid dị na mmiri ara ara dị mkpa iji hụ na ha tolitere.Nnyocha e mere egosiwo na ọkwa sialic acid na ndị nne na-amụ nwa na-ebelata ka oge na-aga.Ya mere, iji sialic acid na-aga n'ihu n'oge ime ime na mgbe ime ime nwere ike inye aka ịnọgide na-enwe ọkwa sialic acid n'ime ahụ.Ọzọkwa, ọdịnaya nke sialic acid na-ejikọta ya na ọdịnaya DHA nke ọma, na-atụ aro na ọ ga-abụ na ọ ga-ejikọta ya na nhazi ụbụrụ na mmepe ọrụ ụbụrụ na ụmụ ọhụrụ, nke abụọ nwere ike ịba uru maka mmalite ụbụrụ ụbụrụ.

Nnyocha egosiwo na oge ọla edo nke ụbụrụ mmadụ na-etolite n'etiti afọ 2 na 2 afọ.Oge a bụ oge dị oke egwu maka ngbanwe ọnụọgụ mkpụrụ ndụ ụbụrụ, mmụba olu, izu oke arụ ọrụ, na nhazi netwọkụ akwara.Ya mere, ndị nne maara ihe ga-aṅa ntị na oriri nke sialic acid zuru oke n'oge ime ime.Mgbe a mụsịrị nwa, mmiri ara ara bụ ụzọ dị irè isi tinye sialic acid na nwa ọhụrụ, n'ihi na ihe dịka 0.3-1.5 mg nke sialic acid kwa milliliter nke mmiri ara ara.N'ezie, ụmụ anụmanụ niile, gụnyere ụmụ mmadụ, na-enwe ike ịmepụta sialic acid site na imeju n'onwe ha.Otú ọ dị, mmepe imeju nke ụmụ amụrụ ọhụrụ etolitebeghị, na mkpa maka uto ngwa ngwa na mmepe nke ụbụrụ nwere ike igbochi njikọ nke sialic acid, karịsịa maka ụmụ ọhụrụ akabeghị aka.Ya mere, sialic acid na mmiri ara ara dị mkpa maka ịhụ na uto na mmepe nke nwa ọhụrụ.
Ndị nyocha Ọstrelia achọpụtala na ụmụ ọhụrụ na-enye nwa ara nwere oke sialic acid dị n'ihu cortex karịa ụmụ ọhụrụ a na-enye nri.Nke a nwere ike ịkwalite nguzobe nke synapses, nyere ebe nchekwa nwa aka ka ọ bụrụ ntọala siri ike karị, ma wusie mmepe nke usoro ụjọ ahụ ike.

Kedu ihe bụ Sialic acid

Sialic acidbụ otu ntọhapụ nke neuraminic acid (N- ma ọ bụ O-dochiri amịpụta neuraminic acid).Ọtụtụ mgbe n'ụdị oligosaccharides, glycolipids ma ọ bụ glycoproteins.

Sialic acidbụkwa aha onye otu a kacha bụrụ N-acetylneuramine (Neu5Ac ma ọ bụ NANA).

Ezinụlọ Sialic acid

Amara ya maka ihe fọrọ nke nta ka ọ bụrụ ndị otu 50, ihe niile sitere na neuraminic acid 9-carbon sugar ebubo na-adịghị mma.

N-acetylneuramine (Neu5Ac), N-glycolylneuramine

acid (Neu5Gc) na deaminoneuramine (KDN) bụ isi monomer ya.

N-acetylneuraminic acid bụ naanị ụdị Sialic Acid na ahụ anyị.

Sialic acid na akwụ nnụnụ

N'ihi na Sialic acid bara ụba na akwụ nnụnụ, a na-akpọkwa ya acid nest nke nnụnụ, nke bụ ihe dị mkpa na-egosi akara nrị nnụnụ.

Sialic acid bụ isi ihe oriri na-edozi ahụ na akwụ nnụnụ, ihe dịka 3%-15% site n'ịdị arọ.

N'ime nri niile a ma ama, akwụ nnụnụ nwere ọdịnaya Sialid acid kachasị elu, ihe dị ka ugboro 50 karịa nri ndị ọzọ.

Akwu nnụnụ 1g hà nha 40 ma ọ bụrụ na anyị ga-enweta otu Sialic Acid.

Isi mmalite nri sialic acid

N'ozuzu, osisi enweghị sialic acid.Ihe na-ebute ụzọ nke Sialic acid bụ mmiri ara ehi mmadụ, anụ, akwa, na cheese.

Ọdịnaya nke mkpokọta Sialic acid na nri ndị a na-ahụkarị (µg/g ma ọ bụ µg/ml).

Anyị nwere ike ịhụ na Sialic acid dị na mmiri ara ehi mmadụ dị elu, nke bụ isi ihe na-eme ka ụbụrụ nwa ọhụrụ nwee ọganihu.

Mana ọdịnaya Sialic acid dị iche na oge dị iche iche mmiri ara ehi mmadụ

Colostrum mmiri ara ehi 1300 +/- 322 mg / l

Ụbọchị 10 ka e mesịrị 983 +/- 455 mg / l

ntụ ntụ mmiri ara ehi nwa ọhụrụ 197 +/- 31 mg / l

Usoro mmiri ara ehi anabatara 190 +/- 31 mg / l

Usoro mmiri ara ehi gbanwetụrụ 100 +/- 33 mg/l

Usoro mmiri ara ehi na-esote 100 +/- 33 mg / l

Usoro mmiri ara ehi nke soy 34 +/- 9 mg/l

E jiri ya tụnyere mmiri ara ara, mmiri ara ehi nwa ọhụrụ nwere ihe dịka 20% Sialic acid sitere na mmiri ara ehi mmadụ, ebe nwatakịrị nwere ike nweta naanị 25% Sialic acid site na mmiri ara ara.

Maka nwa tupu oge eruo, Sialic acid dị mkpa karịa nwa ahụ siri ike na mmepe ụbụrụ.

Ọmụmụ Sialic Acid na ntụ ntụ mmiri ara ehi

Nsonaazụ gosiri na ọdịnaya sialic acid ụbụrụ na-arụ ọrụ dị mkpa n'ịchọpụta omume.Otu ọzọ hụrụ ka mmụta ka mma site na ọgwụgwọ sialic acid n'efu na òké.

Nyochaa CAB: Echiche na Agriculture, Sayensị anụmanụ anụmanụ, Nutrition, na eke

Akụrụngwa 2006 1, Mba. 018, Sialic acid ọ bụ nri mmiri ara ehi maka ụbụrụ? ， Bing Wang

"Nkwubi okwu a bụ ụbụrụ ganglioside dị elu na glycoprotein sialic acid n'ime ụmụ ọhụrụ na-enye mmiri ara ehi na-egosi mmụba synaptogenesis na ọdịiche dị na mmepe neurodevelopment."

Am J Clin Nutr 2003;78:1024–9.E bipụtara ya na USA.© 2003 American Society for Clinical Nutrition, Brain ganglioside, na glycoprotein sialic acid n'ime ara ara ma e jiri ya tụnyere ụmụ ọhụrụ na-enye nri, Bing Wang

"Mkpụrụ ndụ sel neural nwere sialic acid ugboro 20 karịa ụdị akpụkpọ anụ ndị ọzọ, na-egosi na sialic acid nwere ọrụ doro anya na nhazi akwara."

Akwụkwọ akụkọ European Journal of Clinical Nutrition, (2003) 57, 1351-1369, Ọrụ na ikike nke sialic acid na nri mmadụ, Bing Wang

Ngwa N-Acetylneuramine

Mmiri ara ehi ntụ ntụ

Ka ọ dị ugbu a, ntụ ntụ mmiri ara ehi nne na-enye nwa ara, ntụ ntụ mmiri ara ehi nke ụmụ ọhụrụ, na ihe mgbakwunye nri nwere Sialic Acid n'ahịa.

Maka Ndị Nne Na-enye Nwa ara

N'ihi na Baby Milk ntụ ntụ 0-12 ọnwa

Maka ngwaahịa nlekọta ahụike

Maka ihe ọṅụṅụ

Ebe ọ bụ na Sialic acid nwere ezigbo ike soluble mmiri, ọtụtụ ụlọ ọrụ na-agbalị ịmepụta ihe ọṅụṅụ Sialic acid maka ahụike Brain ma ọ bụ tinye n'ime ngwaahịa mmiri ara ehi.

N-Acetylneuraminic acid nchekwa

N-Acetylneuraminic acid dị oke nchebe.Ka ọ dị ugbu a, ọ nweghị akụkọ ọjọọ a kọrọ na Sialic acid.

Gọọmentị USA, China na EU kwadoro Sialic acid ka ejiri ya na ngwaahịa nlekọta nri na ahụike.

USA

Na 2015, N-Acetyl-D-neuraminic acid (Sialic acid) ekpebiela na a na-amatakarị dị ka Nchekwa (GRAS)

China

N'afọ 2017, Gọọmenti China kwadoro N-Acetylneuraminic acid dị ka ngwa nri nri ọhụrụ.

EU

Nchekwa nke N-acetyl-d-neuraminic acid sịntetik dị ka nri ọhụrụ n'okpuru Iwu (EC) Mba 258/97

Na 16 October 2015, European Commission nyere Ultragenyx UK Limited aha ụmụ mgbei (EU/3/12/972) maka sialic acid (nke a makwaara dị ka aceneuramic acid) maka ọgwụgwọ GNE myopathy.

Echiche Sayensị na nkwado nke nkwupụta ahụike metụtara sialic acid na mmụta na ebe nchekwa (ID 1594) dabere na Nkeji edemede 13 (1) nke Iwu (EC) Mba 1924/2006

Usoro onunu ogwu

CFDA na-atụ aro 500mg / ụbọchị

Nri ọhụrụ na-atụ aro 55mg / ụbọchị maka Nwa ọhụrụ yana 220mg kwa ụbọchị maka ụmụ nwanyị na-eto eto na ndị agadi.

N-acetylneuraminic acid ọrụ

Nkwalite ebe nchekwa na ọgụgụ isi

Site na mmekorita ya na membranes cell cell na synapses, Sialic acid na-abawanye ọnụego nzaghachi nke synapses na mkpụrụ ndụ akwara ụbụrụ, si otú ahụ na-akwalite mmepe nke ebe nchekwa na ọgụgụ isi.

Ndị ọkà mmụta sayensị New Zealand emewo usoro nnwale iji kwado ọrụ dị oke mkpa nke acid akwu nnụnụ na mmepe ọgụgụ isi ụmụaka.N'ikpeazụ, ndị nchọpụta ahụ kwubiri na ịgbakwụnye acid akwu nnụnụ n'ime ụmụ ọhụrụ nwere ike ịbawanye ụba nke acid akwu nnụnụ na ụbụrụ, si otú ahụ mee ka ụbụrụ nwee ike ịmụta ihe.

Melite ikike nnabata eriri afọ

Dị ka mfe anụ ahụ onu nke na-abụghị nwoke ma ọ bụ nwanyị ibe, ndị ziri ezi ebubo mineral na ụfọdụ vitamin na-abanye n'ime eriri afọ na-adị mfe jikọtara na ike na-ezighị ezi ebubo nnụnụ akwu acid, otú nsia absorption nke vitamin na mineral.Ewelitela ikike site na ya.

Na-akwalite mkpochapụ nje antibacterial nke eriri afọ

Sialic acid na protein membrane cell na-arụ ọrụ dị oke mkpa n'ịkwalite ikike nnabata cell, detoxification nke toxin cholera, mgbochi ọrịa Escherichia coli pathological, na nhazi nke protein ọbara ọkara ndụ.

Ogologo ndụ

Sialic acid nwere mmetụta nchebe na nkwụsi ike na sel, na enweghị sialic acid nwere ike ibute mbelata ndụ sel ọbara yana mbelata nke glycoprotein metabolism.

Mepụta ọgwụ ọhụrụ maka Sialic Acid

Ndị ọkà mmụta sayensị na-anwa iji ọgwụ sialic acid na-egbochi ọrịa adhesion agwọ ọrịa afọ.Sialic acid ọgwụ mgbochi nrapado nwere ike ịgwọ Helicobacter pylori iji gwọọ ọnya afọ na ọnya duodenal.

Sialic acid bụ glycoprotein.Ọ na-ekpebi nnabata na njikọta nke mkpụrụ ndụ ma nwee mmetụta mgbochi mkpali nke ụlọ ọgwụ dịka aspirin.

Sialic acid bụ ọgwụ maka etiti etiti ma ọ bụ ọrịa akwara ozi na ọrịa demyelinating;sialic acid bụkwa ihe na-atụ anya ụkwara.

Sialic acid dị ka akụrụngwa nwere ike ịmepụta usoro ọgwụ shuga dị mkpa, mgbochi nje, mgbochi tumor, mgbochi mkpali, na ọgwụgwọ nke ịda mbà n'obi nwere nsonaazụ pụtara ìhè.

Usoro mmepụta nke Sialic Acid

Ngwa ngwa mmalite bụ glucose, ọka steepu mmanya, glycerin, na magnesium sulfate.Anyị na-ejikwa teknụzụ fermented.N'oge usoro a, anyị na-eji ụzọ sterilization mee ka ihe dị ọcha.Mgbe ahụ site na hydrolysis, itinye uche, ihicha, na ịkụpịa.Mgbe usoro niile gasịrị, anyị na-enweta ngwaahịa ikpeazụ.Na QC anyị ga-eji HPLC nwalee ogo ihe maka batch ọ bụla tupu anyị ebugara ndị ahịa ya.

Aha ngwaahịa: Sialic acid;N-Acetylneuraminic acid

Aha ndị ọzọ: 5-Acetamido-3,5-dideoxy-D-glycero-D-galactonulosonic acid o-Sialic acid Galactononulosonic acid Lactaminic acid NANA N-Acetylsialic acid

Mmalite: Akwu nnụnụ oriri
Nkọwa: 20%-98%
Ọdịdị: ọcha ezigbo ntụ ntụ
Nọmba .: 131-48-6
MW: 309.27
MF: C11H19NO9

Ebe Mmalite: China

Nchekwa: Chekwaa n'ebe dị jụụ & akọrọ, zere ọkụ na ikpo ọkụ.
Ndaba: Afọ abụọ ma ọ bụrụ na echekwara ya nke ọma.

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