Dzina lazogulitsa:Chithunzi cha CMS121

Dzina Lina:CMS-121;

1,2-Benzenediol,4--[4-(cyclopentyloxy)-2-quinolinyl]-;

4-(4-(cyclopentyloxy)quinolin-2-yl)benzene-1,2-diol(CMS121);

ACC,AcetylCoenzymeACarboxylase, matenda, neuroprotective,inhibit,anti-inflammatory,mitochondrial,Alzheimer's,antioxidative,acetylation,Inhibitor,H3K9,Acetyl-CoACarboxylase,CMS121,dementia,ACC1,CMS-121

CAS NO.:1353224-53-9

Kuyesa: 98.0% Min

Mtundu: Ufa wachikasu wopepuka

Kuyika: 25kg / DRUMS

4-(4-(cyclopentyloxy)quinolin-2-yl)benzene-1,2-diol ndi gulu lomwe limatchedwanso CMS121. Kapangidwe kakapangidwe kawo kakuwonetsa kuti akhoza kukhala ndi mawonekedwe apadera komanso momwe angagwiritsire ntchito. Kuti timvetsetse kufunikira kwake, zimathandiza kuzindikira magulu ogwira ntchito omwe alipo ndikuwunika momwe angakhudzire

CMS121 ndi quin oline yolowa m'malo yomwe imakhala ndi neuroprotective, anti-inflammatory, antioxidative, and renoprotective activities. Imasunga milingo ya glutathione (GSH) m'maselo a HT22 a mbewa a hippocampal mu vitro pamaso pa glutamate, imapangitsa kusiyana kwa ma cell a PC12, imalepheretsa LPS-induced N9 microglial activation ndi 82% mu N9 microglia, ndikuwononga ma radicals aulere mumtundu wofanana wa Trolox. (TEAC) mayeso. CMS121 imateteza ku ischemia ndi oxytosis mu zowonetsera phenotypic mu HT22 maselo mu vitro ndi EC50 makhalidwe 7 ndi 200 nM pofuna kupewa iodoacetic acid- kapena glutamate-induced selo cell, motero. Zimakhalanso zoteteza, kuchepetsa kulemera kwa impso ndikuchepetsa mawu a TNF-α, caspase-1, ndi inducible nit ric oxi de synthase (iNOS) mu chitsanzo cha SAMP8 cha mbewa cha matenda aakulu a impso omwe amagwirizanitsidwa ndi kukalamba mofulumira pamene akugwiritsidwa ntchito pa mlingo. 10 mg/kg patsiku kuyambira ali ndi miyezi isanu ndi inayi.

4-(4-(cyclopentyloxy)quinolin-2-yl)benzene-1,2-diol ndi gulu lomwe limatchedwanso CMS121. Kapangidwe kakapangidwe kawo kakuwonetsa kuti akhoza kukhala ndi mawonekedwe apadera komanso momwe angagwiritsire ntchito. Kuti timvetsetse kufunikira kwake, zimathandiza kuzindikira magulu ogwira ntchito omwe alipo ndikuwunika momwe angakhudzire. Kukhalapo kwa mphete ya quinoline kukuwonetsa kuti pawiriyo ikhoza kukhala yogwira ntchito mwachilengedwe. Mamolekyu opangidwa ndi quinoline amadziwika ndi mitundu yosiyanasiyana yachilengedwe, kuphatikiza antibacterial ndi anti-yotupa. Kuphatikizika kwa gulu la cyclopentyloxy kumatha kuthandizira kusungunuka kwa pawiri kapena kupititsa patsogolo ntchito yake yachilengedwe kudzera muzowopsa. M'maphunziro a maselo a HT22, CMS-121 yawonetsa zotsatira zazikulu za neuroprotective, kuteteza bwino maselowa ku ischemia ndi kuwonongeka kwa okosijeni. Kuphatikiza apo, CMS-121 ili ndi zotsutsana ndi zotupa, zomwe zikuwonetsa kuthekera kwake kosinthira mayankho otupa. Pochita zimenezi, CMS-121 imatha kuchepetsa kutupa m'magulu osiyanasiyana ndi ziwalo. CMS-121 ili ndi ntchito yamphamvu yamankhwala monga choletsa cha acetyl-CoA carboxylase 1 (ACC1). Mphamvu yake yoletsa pa ACC1 imapangitsa kuti ikhale yodalirika

Ntchito:

CMS-121 (CMS121) ndi buku komanso lamphamvu lochokera ku fisetin yokhala ndi anti-aging, neuroprotective, anti-inflammatory, antioxidative, and renoprotective activities.CMS-121 ndi quinolone yochokera ku quinolone komanso yogwira ntchito pamlomo acetyl-CoA carboxylase 1 (ACC1) inhibitor yokhala ndi zolonjeza za pharmacological. Kafukufuku wochuluka wachitika kuti afufuze za ubwino wa CMS-121 m'madera osiyanasiyana, kuphatikizapo neuroprotection, anti-inflammatory effects, antioxidant ntchito, ndi zotsatira zake pa zizindikiro zokhudzana ndi ukalamba wathanzi.