Dzina lazogulitsa:Lemairamin (WGX-50)

Dzina Lina:2-Propenamide, N-[2-(3,4-dimethoxyphenyl)ethyl]-3-phenyl-, (2E)-;Lemairamin (WGX-50)

Nambala ya CAS:29946-61-0

Zotsatira: 98.0%Min

Mtundu: ufa woyera mpaka woyera

Kulongedza:25kg /ng'oma

Lemairamin kapena Wgx50 ndi mankhwala achilengedwe otengedwa ku tsabola omwe awonetsa zotsatira zabwino popewa matenda a Alzheimer's. Kafukufuku wapeza kuti imatha kuletsa Aβ-kupangitsa neuronal apoptosis, kuchepetsa kawopsedwe ka neuronal calcium, ndikuchepetsa kudzikundikira kwa Aβ oligomers mu cerebral cortex. Kuphatikiza apo, wgx50 yawonetsedwa kuti imathandizira kuzindikira kwa mbewa. Kafukufuku akuwonetsa kuti wgx50 ili ndi kuthekera koletsa kuphatikiza kwa mapuloteni ndi mapuloteni pakati pa mamolekyu a amyloid. Ponseponse, wgx50 imatha kupewa matenda a Alzheimer's ndipo ikhoza kupereka njira zatsopano zopangira mankhwala omwe akulunjika ku A.β oligomers. Kuphatikiza apo, WGX-50 imawonetsa ntchito yayikulu yolimbana ndi kutupa, zomwe zimapangitsa kuti ikhale yodalirika pochiza matenda otupa. WGX-50 yapezeka kuti ili ndi zotsatirapo zazikulu pakhungu, monga kuchepetsa makwinya komanso kuwongolera khungu. Kuphatikiza pa mankhwala achilengedwe omwe amachokera ku chomera cha Zanthoxylum bungeanum, pakali pano pali zowonjezera zowonjezera zomwe zimagwiritsidwa ntchito pazinthu zosiyanasiyana ndipo ndizofunikira kwambiri pamsika.

Ntchito:

1. Analgesic effect: Xanthoxylin ili ndi mphamvu yochepetsera ululu ndipo imatha kuthetsa ululu. Imatha kulimbikitsa zolandilira kutentha kwa thupi, kusintha momwe ululu umafalikira, ndikutulutsa zinthu zomwe zimachepetsa ululu, potero zimachepetsa kusapeza bwino monga mutu ndi nyamakazi.
2. Antibacterial effect: Xanthophyllin imakhala ndi antibacterial effect, yomwe imatha kulepheretsa kukula kwa mabakiteriya ndi bowa. Amagwiritsidwa ntchito kwambiri m'makampani azakudya ndi zinthu zachipatala kuti asunge chakudya chatsopano ndikuwonjezera moyo wake wa alumali.
3. Limbikitsani chimbudzi: Xanthoxylum imatha kulimbikitsa katulutsidwe ka tiziwalo timene timatulutsa m'mimba, kuwonjezera katulutsidwe ka madzi am'mimba ndi malovu, potero kulimbikitsa kagayidwe kachakudya. Ithanso kuthetsa mavuto a GI monga kukokana kwa GI ndi acid reflux.
4. Antioxidant effect: Xanthophyllin ndi antioxidant wamphamvu yomwe imatha kusokoneza ma radicals aulere ndikuchepetsa kuwonongeka kwa ma cell chifukwa cha kupsinjika kwa okosijeni. Izi zimathandizira kuchedwetsa kukalamba kwa ma cell, kumateteza thanzi la mtima ndi mitsempha yamagazi, ndikuletsa kukula kwa matenda osatha.

Ntchito:

Lemairamin ndi mankhwala opangidwa kuchokera ku khungwa la Zanthoxylum bungeanum. Pakalipano amagwiritsidwa ntchito ngati zakudya zowonjezera zakudya, zimakhalanso ngati agonist wa alpha7 nicotinic acetylcholine receptor (α7nAChR), yomwe imachepetsa neuroinflammation mu matenda a Alzheimer's. α7nAChR), yomwe imachepetsa neuroinflammation mu matenda a Alzheimer's, ndipo kwathunthu synthetic.Wgx50 yasonyeza zotsatira zolimbikitsa m'maphunziro a preclinical, kuphatikizapo kuletsa Aβ-induced neuronal apoptosis, kuchepetsa neuronal calcium toxicity, kuchepetsa kuchulukira kwa Aβ oligomers mu cerebral cortex, ndi kupititsa patsogolo chidziwitso cha mbewa.