Dzina lazogulitsa:Evodiamine

Dzina Lina:Evodiamine, Isoevodiamine, (+)-Evodiamine, d-Evodiamine,Fructus Evodiae Extract

Nambala ya CAS:518-17-2

Chiwerengero: 98% Min

Mtundu: Ufa wonyezimira wachikasu wonyezimira

Kulongedza: mu 25kgs fiber ng'oma

Kusungirako: Sungani chidebe chosatsegulidwa pamalo ozizira, owuma, Khalani kutali ndi kuwala kwamphamvu

Shelf Life: Miyezi 24 kuyambira tsiku lopangidwa

Evodiamine ndi wapadera bioactive alkaloid ndi waukulu bioactive pophika mu chikhalidwe Chinese mankhwala. Amapezeka mu zipatso za chomera cha Evodia evodia, chomwe chimamera makamaka ku China ndi Korea. Amapezeka mu zipatso za Evodia evodia chomera, chomwe chimamera makamaka ku China ndi Korea. Chomerachi chimakhala ndi mitundu yosiyanasiyana yamankhwala ndipo chakhala chikugwiritsidwa ntchito ngati mankhwala achi China kuchiza matenda osiyanasiyana, kuphatikiza kusagaya m'mimba, kutupa, komanso kupweteka. Evodiamine imagwira ntchito poyang'ana njira zosiyanasiyana zamagulu m'thupi. Amadziwika kuti amalimbikitsa kuyambitsa kwa vanillin receptors, zomwe zimagwira ntchito yofunika kwambiri pakuzindikira ululu ndi thermogenesis. Kuonjezera apo, zapezeka kuti zimagwirizana ndi serotonin ndi dopamine receptors, kutanthauza kuti ili ndi mphamvu zowonjezera maganizo.

Tizilombo toyambitsa matenda: Evodiamine ndi alkaloid yodzipatula ku chipatso cha Bentham, yomwe ili ndi zochitika zosiyanasiyana zamoyo monga anti-inflammatory, anti kunenepa, ndi anti-chotupa. In vitro: Evodiamine yawonetsa cytotoxicity motsutsana ndi mizere yama cell a khansa yamunthu poyambitsa apoptosis. Kuphatikiza apo, ndi mamolekyu achilengedwe othana ndi chotupa omwe amalimbana ndi chotupa kudzera munjira zosiyanasiyana zama cell monga njira zodalira caspase komanso zosadalira, njira ya sphingomyelin, siginecha ya calcium / JNK, 31 PI3K/Akt/caspase, ndi Fas. -L/. NF - κ B njira yowonetsera 32 [1]. Mu vivo: Evodiamine imalepheretsa metabolism ya dapoxetine. Poyerekeza ndi gulu lolamulira, t1 / 2, AUC (0- ∞), ndi Tmax pharmacokinetic magawo a dapoxetine mu gulu la evodiamine adawonjezeka kwambiri ndi 63.3%, 44.8%, ndi 50.4%, motero. Kuonjezera apo, evodiamine inachepetsa kwambiri t1 / 2 pharmacokinetic magawo ndi AUC (0- ∞) ya demethylated dapoxetine [2]. Evodiamine imalepheretsa kukula kwa chotupa mu subcutaneous H22 xenograft model. Evodiamine imachepetsa VEGF yochititsa angiogenesis mu vivo.

In vitro: Evodiamine amawonetsa cytotoxicity motsutsana ndi mizere yamitundu yosiyanasiyana ya khansa yamunthu poyambitsa apoptosis. Kuphatikiza apo, ndi mamolekyu achilengedwe othana ndi chotupa omwe amalimbana ndi chotupa kudzera munjira zosiyanasiyana zama cell monga njira zodalira caspase komanso zosadalira, njira ya sphingomyelin, siginecha ya calcium / JNK, 31 PI3K/Akt/caspase, ndi Fas. -L/. NF - κ B njira yowonetsera 32 [1].

Mu vivo: Evodiamine imalepheretsa metabolism ya dapoxetine. Poyerekeza ndi gulu lolamulira, t1 / 2, AUC (0- ∞), ndi Tmax pharmacokinetic magawo a dapoxetine mu gulu la evodiamine adawonjezeka kwambiri ndi 63.3%, 44.8%, ndi 50.4%, motero. Kuonjezera apo, evodiamine inachepetsa kwambiri t1 / 2 pharmacokinetic magawo ndi AUC (0- ∞) ya demethylated dapoxetine [2]. Evodiamine imalepheretsa kukula kwa chotupa mu subcutaneous H22 xenograft model. Evodiamine imachepetsa VEGF yochititsa angiogenesis mu vivo.

NTCHITO:

Anti-inflammatory, anti-tumor, and hypoglycemic activations ali ndi chithandizo chamankhwala pochiza matenda a dementia oyambilira ndi sitiroko. Imakhala ndi analgesic, imachepetsa kuthamanga kwa magazi komanso imayambitsa kutentha kwa thupi. Ntchito yachipatala ya mankhwalawa ndikupanga othandizira azachipatala a okodzetsa ndi thukuta.

1. Evodia Tingafinye ntchito pofuna kuchiza zizindikiro za kuvutika m'mimba. Izi ndi monga nseru, kusanza, ndi kutsekula m’mimba. Akuti ndi othandiza makamaka pochiza matenda otsekula m'mawa.

2. Evodia amagwiritsidwa ntchito kulimbikitsa chilakolako komanso kuchiza zizindikiro za m'mimba zomwe zimagwirizanitsidwa ndi kusowa chidwi ndi chakudya.

3. Evodia Extract imakhalanso ndi anti-yotupa, anti-tumor, anti-viral, astringent, ndi diuretic properties.

4. Evodiamine ndi analgesia, kuchepetsa kuthamanga kwa magazi ndi kutentha kwa thupi kukwera ndi zotsatira zina zamankhwala.

5. Evodiamine ali stomachic, kusiya retching, oxyrygmia kwenikweni ndi okodzetsa kwenikweni.

6.Evodiamine imakhala ndi mphamvu yoletsa ku li; ndi mphamvu yowononga tizilombo pa ascarissuum;

7.Evodiamine imathanso kuchepetsa chiberekero ndikuwonjezera kuthamanga.

8.Besides, evodiamine imakhalanso ndi zotsatira zabwino pa matenda a Alzheimer's and stroke.

Ntchito: