Dzina lazogulitsa:Galantamine Hydrobromide

Dzina Lina:Galanthamine hydrobromide;Galantamine HBr; Galanthamine HBr;(4aS,6R,8aS)-4a,5,9,10,11,12-hexahydro-3-methoxy-11-methyl-6H-Benzofuro [3a,3,Hydrobromide

CAS NO:1953-04-4

Zofotokozera:98.0%

Mtundu:Choyeraufa ndi khalidwe fungo ndi kukoma

Mkhalidwe wa GMO: GMO Yaulere

Kulongedza: mu 25kgs fiber ng'oma

Kusungirako: Sungani chidebe chosatsegulidwa pamalo ozizira, owuma, Khalani kutali ndi kuwala kwamphamvu

Shelf Life: Miyezi 24 kuyambira tsiku lopangidwa

Galantamine imagwiritsidwa ntchito pochiza matenda a Alzheimer's wofatsa mpaka pang'ono komanso zovuta zina za kukumbukira, makamaka zamtima. Ndi alkaloid yomwe imapezeka mopanga kapena kuchokera ku mababu ndi maluwa a Galanthus Caucasicus (Caucasian snowdrop, Voronov's snowdrop), Galanthus woronowii (Amaryllidaceae) ndi genera yofananira monga Narcissus (daffodil)), Leucojum (chipale chofewa cha chipale chofewa kuphatikiza Lyrickoris) Red Spider Lily).

Galanthamine ndi chilengedwe chochokera ku lycoris radiate, ndi alkaloid yapamwamba yochokera ku chipale chofewa komanso mitundu yogwirizana kwambiri. Imakhala ngati reversible competitive acetylcholinesterase inhibitor (ACHE) inhibitor, pamene imachita zofooka pa butyrylcholinesterse(BuChE) imagwiritsidwa ntchito pochiza matenda a m'katikati mwa mitsempha yapakati ndipo ingagwiritsidwe ntchito ngati mankhwala oletsa kupweteka kwa minofu.Galanthamine hydrobromide woyera mpaka pafupifupi ufa woyera; sungunuka pang'ono m'madzi; chloroform yosasungunuka, etha ndi mowa.

Galantamine hydrobromide ndi benzazepine yotengedwa ku mababu ndi maluwa a narcissus, osmanthus, kapena canna. Komanso ndi oral cholinesterase inhibitor. Monga ligand ya nicotinic acetylcholine receptors, yakhala ikugwiritsidwa ntchito kwambiri kupititsa patsogolo ntchito ya neurocognitive. Ntchito yake ndikuletsa mopikisana komanso mosinthika acetylcholinesterase, potero kumawonjezera kuchuluka kwa acetylcholine. Ikalowetsedwa m'magazi, galantamine hydrobromide imalowetsedwa mosavuta m'malo osiyanasiyana a thupi, kuphatikiza muubongo. Imamangiriza ku nicotinic acetylcholine receptors, zomwe zimapangitsa kusintha kosinthika ndikuwonjezera kutulutsidwa kwa acetylcholine. Zimagwiranso ntchito popikisana ndi kubweza zotsatira za cholinesterase inhibitors. Poletsa cholinesterase, imalepheretsa kuwonongeka kwa acetylcholine, potero kumawonjezera milingo ndi nthawi ya neurotransmitter yamphamvu iyi. Galantamine imathanso kupititsa patsogolo kuphunzira ndi kukumbukira, kupewa kutupa muubongo, komanso kukhalabe ndi ma neurotransmitters ambiri posunga kukhulupirika kwa ma neuron ndi ma synapses.

Ntchito:

(1) Anti-cholinesterase .

(2) Limbikitsani ndi kuletsa acetylcholinesterase, kulamulira intracephalic nicotine receptor malo.

(3) Amachiritsa matenda opuwala aang'ono, sweeny ndi myasthenia gravis pseudoparalytica, etc.

(4) Kupititsa patsogolo kuzindikira kwa kuwala, odwala matenda a Alzheimer ofatsa kwambiri, ndikuchedwa kuchepetsa kuchepa kwa maselo a ubongo.

(5) Sinthani kuyendetsa pakati pa mitsempha ndi minofu.

Kugwiritsa ntchito
1. GalanthamineHydrobromideamagwiritsidwa ntchito makamaka mu myasthenia gravis, poliovirus quiescent siteji ndi sequela, komanso polyneuritis, funiculitis ndi sensorimotor chotchinga chifukwa cha mantha dongosolo matenda kapena traumatism;

2. Galanthamine Hydrobromide imagwiritsidwanso ntchito mu matenda a Alzheimer's, ili ndi ntchito yayikulu ya dementia ndi dysmnesia yomwe imayambitsidwa ndi kuwonongeka kwa ubongo.