Dzina lazogulitsa:YDL223C (Mtengo wa HBT1) Ufa

Dzina Lina:Mtengo wa HBT1,YDL223C

CASNo:489408-02-8

Zofotokozera:99.0%

Mtundu:Kuwala chikasu cholimbandi khalidwe fungo ndi kukoma

Mtengo wa GMOMkhalidwe: GMO Yaulere

Kulongedza: mu 25kgs fiber ng'oma

Kusungirako: Sungani chidebe chosatsegulidwa pamalo ozizira, owuma, Khalani kutali ndi kuwala kwamphamvu

Shelf Life: Miyezi 24 kuyambira tsiku lopangidwa

HBT1 ndi molekyu yomwe imatha kumangika kumalo enaake a puloteni ya AMPA-R pamene glutamate ilipo, ndipo kumanga kumeneku kumathandiza kulamulira ntchito ya mapuloteni. Ma receptor a AMPA amawonetsedwa mu dongosolo lonse lamanjenje ndipo amatenga gawo lofunikira pakuyankhulirana kwa neuronal, kukonza zomverera, kuphunzira, kukumbukira, ndi synaptic plasticity. Ma receptor a AMPA ndi omwe amathandizira kwambiri pakutulutsa kosangalatsa kwa ma neurotransmission, amalumikizana mwachangu, mofulumizitsa chisangalalo pama synapses ambiri, ndipo amatenga nawo gawo pakuyankha koyambirira kwa glutamate m'magawo a synaptic. Ma receptor a AMPA nthawi zambiri amawonetsedwa limodzi ndi ma NMDA receptors pa ma synapses, ndipo palimodzi amalimbikitsa njira za synaptic plasticity zomwe zimakhudzidwa ndi kuphunzira, kukumbukira, chisangalalo, ndi neuroprotection. Ubongo wamtundu wa neurotrophic factor (BDNF) ndi neurotrophic factor yomwe imagwira ntchito yofunika kwambiri pakukonza ndi kukulitsa ma neurons ndipo imakhala ndi zotsatira zamphamvu komanso zambiri pakukula, kusiyanitsa, kupulumuka ndi kufa kwa maselo a neuronal ndi osakhala a neuronal. , makina opangira ma neurotransmitter omwe amathandizira ku neuronal plasticity pophunzira ndi kukumbukira. Choncho, ndizofunikira pa thanzi komanso thanzi la mitsempha ya mitsempha.

Ntchito:

1. Yisiti genomic knockout strain
   2. Shmoo nsonga mapuloteni, gawo lapansi la Hub1p ubiquitin-ngati mapuloteni; Zosintha zimakhala ndi zolakwika pakupanga kolowera, potero
   kuphatikiza Hbt1p mu polarized cell morphogenesis; HBT1 ili ndi mawu ofotokozera, YNL195C, omwe adachokera pakubwereza konse kwa ma genome
   3. Amagwiritsidwa ntchito pazamankhwala.
   4. Limbikitsani luntha la m’maganizo.
   5. Limbikitsani kukumbukira ndi kutsamira luso.
   6. Limbikitsani mulingo wolimbikitsa.
   7. Limbikitsani kulamulira kwa cortical / subcortical brain mechanism.
   8. Kupititsa patsogolo luso la kuzindikira.
   9. Kupititsa patsogolo mphamvu za ubongo kuthetsa mavuto ndikuuteteza ku mankhwala aliwonse kapena thupi.

Mapulogalamu:

HBT1 ndi buku lamphamvu kwambiri la AMPA-R [alpha-amino-3-hydroxy-5-methyl-4-isoxazole-propionic acid (AMPA) receptor] potentiator yokhala ndi zotsatira zochepa za agonistic poyerekeza ndi LY451395 ndi OXP1, imapangitsa kupanga kochokera muubongo. neurotrophic factor (BDNF) ndipo imawonetsa pang'ono agonistic mu ma neurons oyambirira. HBT1 imamanga ku ligand-binding domain ya AMPA-R mu glutamate dependent manner