L-ERGOTHIONEINE 99% NDI HPLC
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1. Mwachidule cha mankhwala
L-Ergothioneine(ERT) ndi sulufule yokhala ndi amino acid yochokera ku fermentation yaying'ono, yomwe imapezeka mu bowa mongaTricholoma matsutakendiHericium erinaceus. Zogulitsa zathu ndizoyera kwambiri (≥99% ndi HPLC) ufa wa crystalline ndi CAS No. Imawonetsa kukhazikika kwapadera pamapangidwe a pH 4.0-6.0, kuwapangitsa kukhala abwino kwa ma seramu osamalira khungu, mafuta odzola, ndi zowonjezera pakamwa.
Zofunika Kwambiri:
- Chiyero: ≥99% (COA yotsimikiziridwa ndi HPLC, COA yeniyeni yaperekedwa)
- Kapangidwe ka Molecular: C₉H₁₅N₃O₂S | Kulemera kwa Maselo: 229.3 g/mol
- Kusungunuka: 125 mg/mL m'madzi (mothandizidwa ndi akupanga)
- Zitsimikizo: Non-GMO, Free Allergen, Vegan-Friendly
2. Kuwongolera Ubwino & Njira za HPLC
Njira yathu yowunikira imagwirizana ndi ma protocol omwe amawunikiridwa ndi anzawo:
- Kukonzekera Zitsanzo: 1 mL chikhalidwe sing'anga yophika pa 94 ° C kwa mphindi 10, vortexed (1600 rpm / 30 min), centrifuged (10,000×g/5 min), ndi kusungidwa pa -20 ° C ngati pakufunika .
- HPLC System: Dionex Ultimate 3000 yokhala ndi pulogalamu ya Chromeleon.
- Mzere: Cortecs UPLC T3 (2.1 × 150 mm, 1.6 μm particles, 120 Å pore kukula) .
- Mobile Phase: Gradient elution kuchokera ku 0.1% formic acid mpaka 70% acetonitrile/0.1% formic acid, kuthamanga kwa 0.3 mL/mphindi.
- Kuzindikira: Kuyamwa kwa UV pa 254 nm, LOQ 0.15 mmol/L.
Miyezo Yotsimikizira:
- Mzere: 0.3–10 mmol/L (R²>0.99)
- Kulondola: ≤6% RSD (intra-/inter-assay)
- Kubwezeretsa: ~ 100% kulondola
3. Ubwino Waumoyo & Mapulogalamu
3.1 Kagwiritsidwe Ntchito Zazakudya
- Chitetezo cha Mitochondrial: Imachepetsa kupsinjika kwa okosijeni mwa kuwononga ma hydroxyl radicals (IC₅₀: 2.5 μM) ndi superoxide anions.
- Thandizo la Telomere: Kuchedwetsa kufupikitsa kwa telomere kokhudzana ndi zaka mu vitro.
- Mlingo: Kafukufuku wachipatala akusonyeza kuti 5-20 mg/tsiku imakweza milingo ya plasma ERT kwambiri.
Zofunika:
- Makapisozi: 100 μg–5 mg pa kutumikira (mwachitsanzo, LifeExtension's Essential Youth) .
- Synergistic Blends: Imaphatikizana ndi ferulic acid kuti ipititse patsogolo bioavailability.
3.2 Ntchito Zodzikongoletsera
- Anti-Kukalamba: Imalepheretsa tyrosinase (kuchepetsa 40% pa 0.5% ndende) ndikuteteza elastin ku kuwonongeka kwa UV.
- Malangizo Opanga:
- pH: 4.0-6.0 (kukhazikika bwino)
- Kukhazikika: 0.5-2.0% mu seramu / mafuta odzola
- Kugwirizana: Kukhazikika ndi vitamini C, asidi hyaluronic, ndi peptides.
4. Mafotokozedwe Aukadaulo
| Parameter | Kufotokozera | Buku |
|---|---|---|
| Maonekedwe | White crystalline ufa | |
| Purity (HPLC) | ≥99% | |
| Melting Point | 275-280 ° C (kuwola) | |
| Kusungirako | 2-8 ° C m'chidebe chopanda mpweya | |
| Shelf Life | Miyezi 24 |
5. Chitetezo & Kutsata Malamulo
- Deta Yachitetezo: LD₅₀>2000 mg/kg (mkamwa, makoswe); palibe zotsatirapo zoipa m'mayesero a anthu .
- Zitsimikizo: EU Novel Food Approval (Ergoneine®), FDA GRAS .
- Kugwira: Gwiritsani ntchito ma respirators ovomerezeka a NIOSH ndi magolovesi osamva mankhwala pakukonza mafakitale.
6. Global Supply & Packaging
- Kuyika Zosankha: 1 kg, 10 kg, 1000 kg (matumba a aluminiyamu zojambulazo ndi desiccant) .
- Nthawi Yotsogolera: 3-5 masiku ogwira ntchito (kutumiza padziko lonse kudzera pa DHL/FedEx) .
- Misika Yoperekedwa: USA, EU, Australia, Japan, Brazil.
7. Mawu Ofunika Kwambiri
- Mawu ofunika: “L-Ergothioneine 99%HPLC", "Natural Antioxidant Supplier", "Ergothioneine for Skincare".
- Phatikizani CAS 497-30-3, zonena zachiyero, ndi mawu ogwiritsira ntchito.
