S-adenosyl-L-methionine disulfate tosylate

Dzina la malonda:S-adenosyl-L-methionine disulfate tosylate

Dzina Lina:Ademetionine disulfate tosylate; AdeMethionine Disulfate Tosylate; SAM-TAdemetionine disulfate tosylate; Ademetionine Disulfate Tosylate (SAMENE)

Nambala ya CAS:97540-22-2

Chiwerengero: 98% Min

Mtundu: Ufa Wabwino Woyera

Mkhalidwe wa GMO: GMO Yaulere

Kulongedza: mu 25kgs fiber ng'oma

Kusungirako: Sungani chidebe chosatsegulidwa pamalo ozizira, owuma, Khalani kutali ndi kuwala kwamphamvu

Shelf Life: Miyezi 24 kuyambira tsiku lopangidwa

SAMe imapereka gulu la methyl mumitundu ya biosynthesis ya mapuloteni, ma neurotransmitters, nucleic ndi nucleic acid. Izi zimachitika muzochita zambiri za enzymatic transmethylation.

Adenosylmethionine (SAMe) ndi chinthu chochitika mwachilengedwe chomwe chimapezeka pafupifupi m'minyewa iliyonse ndi madzimadzi m'thupi. Zimakhudzidwa ndi zochitika zambiri zofunika. SAMe imathandizira chitetezo cha mthupi, imasunga ma membrane am'maselo, ndipo imathandizira kupanga ndikuphwanya mankhwala a muubongo, monga serotonin, melatonin, ndi dopamine.

Kutenga SAMe pakamwa kumawoneka ngati kumagwira ntchito komanso ibuprofen ndi mankhwala ena ofanana kuti achepetse zizindikiro za osteoarthritis. Koma anthu ambiri amafunika kumwa SAMe kwa mwezi umodzi asanamve bwino.

Anthu nthawi zambiri amagwiritsa ntchito SAMe pochiza kuvutika maganizo, osteoarthritis ndi matenda a chiwindi. Komabe, SAMe imathanso kuyanjana ndi mankhwala ochepetsa nkhawa.

Ikhoza kuchotseratu zinthu zoipa m’thupi. Izi zikuphatikizapo zitsulo zolemera. Zingalepheretsenso kuwonongeka kwa chiwindi kuchokera ku poizoni wa acetaminophen ndikuthandizira kuteteza mafuta m'chiwindi chanu. Zingathandizenso kuchepetsa kutopa komanso kuchepetsa chiopsezo cha dazi msanga.

M'maselo a eukaryotic, SAM imagwira ntchito monga woyang'anira njira zosiyanasiyana kuphatikizapo DNA, tRNA, ndi rRNA methylation; kuyankha kwa chitetezo cha mthupi; amino acid metabolism; transsulfuration; ndi zina. Muzomera, SAM ndiyofunikira pa biosynthesis ya ethylene, timadzi tambiri tomwe timapanga komanso molekyulu yozindikiritsa.

T-Adenosylmethionine (SAMe) ndi chinthu chochitika mwachilengedwe chomwe chimapezeka pafupifupi m'minyewa iliyonse ndi madzimadzi m'thupi. Zimakhudzidwa ndi zochitika zambiri zofunika. SAMe imathandizira chitetezo cha mthupi, imasunga ma membrane am'maselo, ndipo imathandizira kupanga ndikuphwanya mankhwala a muubongo, monga serotonin, melatonin, ndi dopamine.

Ntchito

Transmethylation

SAMe ndiye wopereka methyl wofunikira kwambiri m'thupi, ndipo zosachepera 35 zosiyana za methyl transferase zapezeka kuti zimafuna SA M ngati wopereka methyl. SAM imagwiritsidwa ntchito popanga zinthu zambiri za nayitrogeni, monga creatine, choline, epinephrine, pinecone, carnitine, ndi myosin.

Transaminopropyl zochita

SAMe imatenga nawo gawo pakupanga kwa bioamines ndi transaminopropyl. Spermidine ndi spermidine ndizofunikira polyamines mu eukaryotes. Pambuyo pa ma deshutters awiri, SAM imapanga 5 '-methiodophyl (MTA), kenako imasamutsa aminopropyl kupita ku puttriamine kapena spermidine kuti apange spermidine ndi spermidine.

Transsulfure zochita

SAMe ndi kalambulabwalo wa mankhwala okhala ndi sulfure monga cysteine ​​ndi glutathione (GSH). SAM imapanga homocysteine ​​​​kusandulika sulfure, kutsatiridwa ndi catabolic generation ya cysteine, yomwe imasinthidwa kukhala glutathione (GS H).

Kugwiritsa ntchito

Chithandizo cha tizilombo hepatitis

Monga exogenous adenosylmethionine, S-adenosylmethionine akhoza kuthandizira adenosylmethionine amkati mwa ana omwe ali ndi kuwonongeka kwa chiwindi, kuchepetsa kufalikira kwa enterohepatic kwa cholic acid, kuteteza maselo owonongeka a chiwindi, ndikulimbikitsanso kuyambiranso kwa jaundice. Kuphatikiza apo, S-adenosine methionine imathandizanso pochiza matenda a chiwindi akhanda.

Chithandizo cha uchidakwa chiwindi matenda

Kafukufuku apeza kuti s-adenosine mu mankhwala a odwala matenda a chiwindi choledzeretsa akhoza kwambiri kusintha osauka njala, nseru, kusanza, kutopa, m`mimba, kuyabwa ndi zizindikiro zina, pa nthawi yomweyo kuchepetsa seramu bilirubin ndi kusintha chiwindi ntchito. ali ndi zotsatira zabwino, ndi ntchito otetezeka, palibe zoonekeratu zokhwima anapezeka mu ndondomeko ya mankhwala. Koma kuchiza kwa chiwindi cha uchidakwa, kuleka kumwa mowa n’kofunika kwambiri, kulinso njira yake yochiritsira yofunika kwambiri.

Chithandizo cha intrahepatic cholestasis wa mimba

S-adenosyl-L-methionine ufa ukhoza kupititsa patsogolo kwambiri zizindikiro za biochemical za cholestasis ndi prurituria zizindikiro, kotero zimaganiziridwa kuti S-adenosine ndi imodzi mwa mankhwala otetezeka komanso othandiza pochiza intrahepatic cholestasis.