Dzina lazogulitsa:Agomelatine

Dzina Lina:N-[2-(7-Methoxy-1-naphthyl)ethyl]acetamide;N-[2-(7methoxynaphthalen-1-yl)ethyl]acetamide

Nambala ya CAS:138112-76-2

Zofunika: 99.0%

Mtundu: ufa woyera woyera wokhala ndi fungo labwino komanso kukoma kwake

Mkhalidwe wa GMO: GMO Yaulere

Kulongedza: mu 25kgs fiber ng'oma

Kusungirako: Sungani chidebe chosatsegulidwa pamalo ozizira, owuma, Khalani kutali ndi kuwala kwamphamvu

Shelf Life: Miyezi 24 kuyambira tsiku lopangidwa

Agomelatinendi mtundu watsopano wa antidepressant. Kachitidwe kake kachitidwe kake kamene kamadutsa mumtundu wa monoamine transmitter system.Agomelatine ndi melatoninergic agonist ndi otsutsa osankhidwa a 5-HT2C receptors, ndipo awonetsedwa kuti akugwira ntchito mu zinyama zingapo za kuvutika maganizo. Agomelatine (S20098) amawonetsa pKi mtengo wa 6.4 ndi 6.2 kwachilengedwe (nkhumba) ndi zolandilira, zamunthu (h)5-hydroxytryptamine (5-HT)2C, motsatana.

Agomelatine ndi mtundu umodzi wa ufa wonyezimira-woyera kapena woyera kapena wolimba. Dzina la IUPAC la mankhwalawa ndi N--[2-(7-methoxynaphthalen-1-yl)ethyl]acetamide. Mankhwalawa ndi a Aromatics Compounds;Aromatics;Neurochemicals;APIS. Iyenera kusungidwa pa -20 ° C Mufiriji.

 
Monga Pharmaceutical Intermediates, Agomelatine amagwiritsidwa ntchito pochiza matenda aakulu a maganizo, kusokonezeka maganizo. Agomelatine amagwiritsidwa ntchito pochiza matenda aakulu a maganizo, matenda a maganizo. The mankhwala mankhwala kwa Nervous dongosolo. Antidepressant, anxiolytic, kusintha kamvekedwe ka tulo ndikuwongolera wotchi yachilengedwe. Agomelatine ndi melatoninergic agonist ndi kusankha antagonist 5-ht2c zolandilira. Agomelatine ndi antidepressant mankhwala. Imatchulidwa ngati norepinephrine-dopamine disinhibitor (NDDI) chifukwa cha kusagwirizana ndi cholandilira cha 5-HT2C. Agomelatine ndi agonist wamphamvu pa melatonin zolandilira zomwe zimapangitsa kuti melatonergic antidepressant yoyamba.

.Agomelatine imagwirizana kwambiri ndi melatonin. Agomelatine ndi agonist wamphamvu pa melatonin zolandilira komanso wotsutsa pa serotonin-2C (5-HT2C) zolandilira, zoyesedwa mu chitsanzo cha nyama cha kupsinjika maganizo.

Agomelatine ndi antidepressant yomwe imagwiritsidwa ntchito pochiza kuvutika maganizo.

Nthawi zambiri ubongo umakhala waluso poonetsetsa kuti tili ndi mankhwala okwanira kuti tigwire bwino ntchito. Koma kuvutika maganizo kungakhudze mankhwala angapo a muubongo.

Mankhwalawa akuphatikizapo noradrenaline, dopamine ndi serotonin; kukhumudwa kumachepetsa milingo ya ma transmitter a ubongo awa. Kupsinjika maganizo kumakhudzanso mankhwala otchedwa melatonin. Kuchepa kwa melatonin kumalumikizidwa ndi kusokonezeka kwa kugona kwathu.

Agomelatine ndi antidepressant yoyamba kuonjezera zochita za melatonin mwachindunji. Imachita izi pochita ngati melatonin pamalo omwe melatonin imagwira ntchito. (Izi zimadziwika kuti melatonin receptors). Powonjezera ntchito ya melatonin, agomelatine imawonjezeranso mwachindunji zochita za noradrenaline ndi dopamine.

Agomelatine idakhazikitsidwa koyamba ku Europe mu 2009 ndipo tsopano yavomerezedwa kuti igwiritsidwe ntchito m'maiko opitilira 70. Mosiyana ndi mankhwala oletsa kuvutika maganizo, agomelatine amagwira ntchito poyang'ana melatonin ndi serotonin receptors mu ubongo. Pochita ngati agonist pa melatonin zolandilira, agomelatine imathandizira kusokoneza kugona komwe kumalumikizidwa ndi kukhumudwa. Njirayi sikuti imangothandiza kukonza kugona komanso imathandizira kubwezeretsanso ma circadian rhythm. Kuphatikiza apo, agomelatine imakhala ngati wotsutsana ndi ma serotonin receptors (5-HT2C receptors). Kuchita kwapadera kwapawiri kumeneku mosadukiza kumapangitsa kupezeka kwa serotonin muubongo, neurotransmitter yomwe imayang'anira kusinthasintha. Powongolera milingo ya serotonin, agomelatine imatha kukhala ngati antidepressant yogwira mtima, yochotsa zizindikiro monga chisoni, kutaya chidwi, kudzimva wolakwa kapena wopanda pake. Kuphatikiza apo, agomelatine ikhoza kupereka mapindu ena. Kafukufuku akuwonetsa kuti zitha kuthandiza kukonza magwiridwe antchito anzeru Kafukufuku akuwonetsa kuthekera kwake kopititsa patsogolo kukumbukira, chidwi, ndi magwiridwe antchito, ndikupangitsa kukhala malo osangalatsa ochita kafukufuku wamtsogolo.

Ntchito:

Agomelatine ingathandize kuwongolera 'body clock' (circadian rhythm) yokhala ndi phindu pa kukhumudwa ndi kugona kwa tulo. Zizindikiro za kuvutika maganizo zimasiyanasiyana malinga ndi munthu mmodzi, koma nthawi zambiri zimakhala zachisoni kosalekeza, kutaya chidwi ndi zinthu zomwe mumakonda, kudziona kuti ndinu opanda pake, vuto la kugona, kumva kuti mukuchedwa, kuda nkhawa kapena kusintha kwa njala ndi kulemera. Kusintha kwa kugona kwanu kwatsiku ndi tsiku ndi chikhumbo chanu ndi zitsanzo za kusokonezeka kwa wotchi ya thupi lanu komwe kumachitika kawirikawiri kupsinjika maganizo.