Magaca Alaabta:Wogonin Bulk Powder

Isha dhirta:Scutellaria baicalensis

CAS Maya:632-85-9

Magac Kale:Vogoni, wagonin, Wogonin hydrate, Vogonin Norwogonin 8-methyl ether

Tilmaamaha: ≥98% HPLC

Midabka: budada jaalaha ah oo leh ur iyo dhadhan sifo

Xaalada GMO:GMO Bilaash

Xirmooyinka: 25kgs durbaannada fiber-ka

Kaydinta: Weelka ha furin meel qabow oo qalalan, ka fogow iftiinka xooggan

Life Life:24 bilood laga bilaabo taariikhda wax soo saarka

Scutellaria baicalensis waxaa ku jira noocyo kala duwan oo kiimiko ah, sida flavonoids kala duwan, diterpenoids, polyphenols, amino acids, saliid kacsan, sterol, benzoic acid, iyo wixii la mid ah.Xididdada qallalan waxay ka kooban yihiin in ka badan 110 nooc oo flavonoids ah sida baicalin, baicalein, wogonoside, iyo wogonin, kuwaas oo ah sheyga ugu muhiimsan ee Scutellaria baicalensis.Soosaar heersare ah sida 80% -90% HPLC Baicalin, 90% -98% HPLC Baicalein, 90% -95% HPLC Wogonoside, iyo 5% -98% HPLC Wogonin

Waxqabadka Vitro: Wogonin waxay joojisaa muujinta hidda-wadaha ee PMA-ku-abuuray COX-2 iyadoo la joojinayo muujinta c-Jun iyo firfircoonida AP-1 ee unugyada A549[1].Wogonin waa horjooge cyclin-ku-tiirsane kinase 9 (CDK9) oo xannibaya fosforyaalka karboxy-terminal domain RNA polymerase II ee Ser.Sidaa darteed, waxay yaraynaysaa isku-darka RNA iyo ka dib hoos u dhigista degdega ah ee borotiinka anti-apoptotic protein myeloid cell leukemia 1 (Mcl-1) ee muddada gaaban ee noolasha taasoo keentay in apoptosis induction ee unugyada kansarka.Wogonin waxay si toos ah ugu xidhan tahay CDK9, iyadoo loo malaynayo inay ku xidhan tahay jeebka ATP-ku xidhidhsan oo ma joojinayo CDK2, CDK4 iyo CDK6 qiyaaso xannibaya dhaqdhaqaaqa CDK9.Wogonin wuxuu doorbidayaa inuu joojiyo CDK9 malignant marka la barbar dhigo lymphocytes caadiga ah.Wogonin sidoo kale waa anti-oxidant awood leh oo awood u leh inuu iska tuuro ?O2?[2].Wogonin waxay si weyn u joojisaa wareejinta NFATc1 ee cytoplasm ilaa xudunta iyo dhaqdhaqaaqa firfircoonida qoraalka.Waxa kale oo ay si weyn u joojisaa kala-soocidda osteoclast waxayna yaraynaysaa qoraalka osteoclast?la xidhiidha immunoglobulin?sida reseptor, tartrate?Wogonin wuxuu joojiyaa dhaqdhaqaaqa N-acetyltransferase

Dhaqdhaqaaqa Vivo:Wogonin waxay xakameysaa koritaanka kansarka bini'aadamka ee xenografts gudaha vivo.Marka la eego qiyaasaha halista u ah unugyada burooyinka, wogonin waxa ay muujisaa ma jirto ama wax yar oo sun ah unugyada caadiga ah sidoo kale ma lahayn sun cad oo xayawaan ah[2].Wogonin wuxuu u horseedi karaa apoptosis murine sarcoma S180 taas oo ka hortagaysa koritaanka burada labadaba gudaha vitro iyo vivo [3].Durida intraperitoneal ee 200 mg/kg Wogonin waxay si buuxda u joojin kartaa unugyada leukemia iyo CEM

Tijaabooyinka unugga:

Unugyada A549 waa dhaqan ku jira saxan 24-ceel ah (1.2 × 105 unug / ceel) 1 maalin kahor daawaynta wogonin.DMSO ama wogonin waxaa lagu daraa unugyada A549 1 saac kahor kicinta PMA, unugguna waxaa lagu darey 6 saacadood oo kale.Unugyada waxa lagu soo ururiyaa daawaynta trypsin-ka iyo tirooyinka unugyada waxa lagu tiriyaa iyadoo la isticmaalayo hemocytometer iyo trypan blue ka saarista.