Magaca Alaabta:Lupeol Powder98%
Isha dhirta: canbaha, Acacia visco, Abronia villosa, kafeega Dandelion.
CASNo:545-47-1
Midabka:Cadaan ilaa caddaanbudo leh ur sifo iyo dhadhan
Tilmaam: ≥98% HPLC
GMOXaalada:GMO Bilaash
Xirmooyinka: 25kgs durbaannada fiber-ka
Kaydinta: Weelka ha furin meel qabow oo qalalan, ka fogow iftiinka xooggan
Life Life:24 bilood laga bilaabo taariikhda wax soo saarka
Waxqabadka Nafleyda:
Lupeol (Clerodol; Monogynol B; Fagarasterol) waa triterpenoid pentacyclic firfircoon, wuxuu leeyahay anti-oxidant, anti-mutagenic, anti-buro iyo firfircoonida ka hortagga bararka.Lupeol waa mid awood lehreceptor androgen(AR) inhibitor waxaana loo isticmaali karaakansarkacilmi baaris, gaar ahaan qanjirka 'prostate'kansarkaof phenotype androgen-dependent (ADPC) iyo phenotype u adkaysta castration (CRPC)[1].
In Vitro Cilmi baaris:
Lupeol waa ka hortag AR oo awood leh oo loo soo saari karo daawo suurtagal ah oo loogu talagalay daaweynta kansarka qanjirka 'prostate' (CaP).Lupeol (10-50 μM) daawaynta 48 h waxay keentay in la xakameeyo koritaanka qiyaasta ku-tiirsanaanta unugyada phenotype androgen-dependent (ADPC), kuwaas oo ah unugyada LAPC4 iyo LNCaP, oo leh IC50 ee 15.9 iyo 17.3 μM, siday u kala horreeyaan.Lupeol waxa kale oo uu hakiyay koritaanka 22Rν_1 oo leh IC50 ee 19.1 μM.Intaa waxaa dheer, Lupeol waxay joojisay koritaanka unugyada C4-2b oo leh IC50 ee 25 μM.Lupeol waxa uu awood u leeyahay inuu joojiyo koritaanka unugyada CaP ee labadaba ADPC iyo CRPC phenotypes.Androgens waxaa loo yaqaanaa inay kaxeeyaan koritaanka unugyada CaP iyada oo loo marayo firfircoonida AR[1]
In Vivo Research:
Lupeol waa daawo waxtar leh oo awood u leh inay joojiso burooyinka unugyada CaP ee gudaha vivo.Wadarta guud ee wareega wareega serum PSA (oo ay ku qarsoon yihiin unugyada burooyinka la geliyo) ayaa lagu qiyaasay dhamaadka daraasadda maalinta 56. Maalinta 56 ka dib tallaalka, heerarka PSA ee u dhexeeya 11.95-12.79 ng / mL ayaa lagu arkay xayawaanka xakamaynta leh burooyinka LNCaP iyo Burooyinka C4-2b, siday u kala horreeyaan.Si kastaba ha ahaatee, kuwa la daweeyay Lupeol waxay soo bandhigeen heerarka serum PSA oo yaraaday oo u dhexeeya 4.25-7.09 ng/mL.Unugyada buro ee xoolaha lagu daweeyay Lupeol waxay muujiyeen heerka serum PSA oo hoos u dhacay marka la barbar dhigo kantaroolka[1]
