Magaca Alaabta:Clastrol bulk bulk
Isha dhirta: The God Vine (Tripterygium wilfordii hook.f)
CASNo:34157-83-0
Midabka: Budada kirisalka orange-ka cas oo leh ur iyo dhadhamin sifa
Tilmaam: ≥98% HPLC
GMOXaalada:GMO Bilaash
Xirmooyinka: 25kgs durbaannada fiber-ka
Kaydinta: Weelka ha furin meel qabow oo qalalan, ka fogow iftiinka xooggan
Life Life:24 bilood laga bilaabo taariikhda wax soo saarka
Budada Celastrolwaa walaxda firfircoon ee Tripterygii Radix, taas oo ah xididka qallalan iyo rizome ee God Vine.Guud ahaan waxaa jira afar nooc oo kala ahTripterygium wilfordii Hook.f, Tripterygium hypoglaucum Hutch, Tripterygium regelii Sprague et Takeda, iyo Tripterygium forresti Dicls.
Diterpenoids: triptolide (cas no.38748-32-2), Tripdiolide (cas no.38647-10-8), iwm.
Triterpenoids: Celastrol (cas no.34157-83-0), Wilforlide A (cas no.84104-71-2), iwm.
Alkaloids:Wilforgine (cas no.37239-47-7), Wolverine (cas no.11088-09-8), wilforidine, iwm.
Tripterygium waa pentazine triterpene oo si dabiici ah looga helo Tripterygium wilfordii.Waxay wax ku ool u tahay daaweynta rheumatoid arthritis-ka.Triptolide waxay ka hortagtaa borotiinka iyo walxaha nukliyeerka ee Kb inay shaqeeyaan.
Celastrol (Tripterin) waa proteasome-ka-hortaye leh waxqabadyo ka-hortagga bararka iyo antioxidant.Waxay si wax ku ool ah oo doorbidaysa u joojisaa hawsha chymotrypsin u eg ee 20S proteasome leh IC50 ee 2.5 μM.
Tripterine waa antioxidant awood leh iyo wakiilka anti-bararka.Waa HSP90-ka-hortagga cusub (wuxuu carqaladeeyaa isku-dhafka Hsp90 / Cdc37), wuxuu leeyahay saameynaha kansarka ka-hortagga (angiogenesis-ka-hortagga muujinta dareenka koritaanka xididdada xididdada dhiigga);antioxidant (waxay joojisaa peroxidation lipid) iyo dhaqdhaqaaqa ka-hortagga bararka (waxay joojisaa wax soo saarka iNOS iyo cytokines bararka)
Baragti ahaanAfirfircoonida:
Celastrol (Tripterin) waxay hoos u dhigtaa basal iyo DNA-ga waxyeeleeya wakiilka FANCD2 monoubiquitination, oo ay ku xigto hoos u dhaca borotiinka.Daawaynta Celastrol waxay meesha ka saaraysaa isbaarada G2 ee IR-ku keentay waxayna kor u qaadaysaa waxyeelada dawada ay keentay ICL ee DNA iyo saamaynta xannibaadda ee unugyada kansarka sanbabada iyadoo la baabi'inayo FANCD2.Celastrol waxay leedahay saameyn wax ku ool ah oo ka hortag ah iyo apoptosis-ku-takoorka unugyada DU145 ee lagu beeray vitro waqti- iyo qaab ku-tiirsanaan.Saamaynta kansarka qanjirka 'prostate' ee Celastrol waa qayb ahaan iyada oo hoos loo dhigayo heerka muujinta kanaalka hERG ee unugyada DU145, taas oo soo jeedinaysa in Celastrol laga yaabo inay noqoto dawada kansarka qanjirka 'prostate' ee suurtogalka ah, farsamadeeduna waxay noqon kartaa inay xannibto kanaalka hERG.Celastrol waxay hagaajisaa colitis-ka tijaabada ah ee jiirarka IL-10 iyada oo la joojinayo dariiqa calaamadaynta PI3K/Akt/mTOR iyo hagaajinta autophagy.Celastrol waxay awood u leedahay inay joojiso dhaqdhaqaaqa cytochrome P450 waxayna sababi kartaa isdhexgalka dhirta.Celastrol waxay ku keentaa apoptosis unugyada TNBC, iyagoo soo jeedinaya in apoptosis laga yaabo in lagu dhexdhexaadiyo iyada oo loo marayo cilladda mitochondrial iyo PI3K/Akt calaamadaha.Celastrol waxay keentaa apoptosis iyo autophagy iyada oo loo marayo dariiqa calaamadaynta ROS/JNK.Celastrol waxay joojisaa dhimashada dopaminergic neuron ee cudurka Parkinson iyada oo dhaqaajisa apoptosis mitochondrial.
Doorka Celastrol ee kiimiko-celinta kansarka:
Chemotherapy ayaa weli ah ikhtiyaarka daawaynta ugu weyn ee bukaanka kansarka.Si kastaba ha ahaatee, daaweynta kemotherabi inta badan waa in lagu daraa daawooyin kale si loo yareeyo waxyeellooyinka xun loogana fogaado caabbinta daroogada.Alaabooyinka dabiiciga ah ayaa si isa soo taraysa loogu isticmaalaa daawaynta adjuvant iyadoo lagu darayo hababka daaweynta kemotherabi ee jira si kor loogu qaado waxtarka daaweynta.Mid ka mid ah tusaalaha ballan-qaadka ah ee daawada dabiiciga ah ee noocan oo kale ah ayaa ah isku-dhafka triterpene ee loo yaqaan 'celastrol', kaas oo laga yaabo inuu leeyahay awood weyn oo loo isticmaalo sidii kiimiko kiimiko ah.Asal ahaan laga aqoonsaday Thunder God Vine, waxay si xun u nidaamisaa unugyo badan oo oncogenic ah sida NF-κB, topoisomerase II, Akt/mTOR, HSP90, STAT3, iyo Notch-1.Kuwani waxay u horseedi karaan jawaab celin ka-hortagga caabuqa, waxay joojiyaan koritaanka burada iyo badbaadada, waxayna tirtiraan angiogenesis.Cutubkani waxa uu si kooban u soo koobayaa doorka suurtogalka ah ee celastrol ka kiimikaad ahaan iyo hababka molecular ee hoose ee dhexdhexaadinta saamaynta kiimikaad ee la soo sheegay ee kansarrada kala duwan.
