L-ERGOTHIONEINE 99% BY HPLC
Antioxidant Premium ee Codsiyada Nutraceutical & Cosmeceutical
1. Dulmarka alaabta
L-Ergothionine(ERT) waa amino acid si dabiici ah u soo baxa baaruud-ka kooban oo laga soo qaatay halsano microbial, ugu horrayn waxaa laga helaa boqoshaada sidaTricholoma matsutakeiyoHericium erinaceus. Alaabtayadu waa nadiif sare (≥99% by HPLC) budada crystalline leh CAS No. 497-30-3, oo lagu ansixiyey falanqaynta chromatographic adag. Waxay muujisaa xasillooni aan caadi ahayn oo ku jirta qaababka pH 4.0-6.0, taasoo ka dhigaysa mid ku habboon serums daryeelka maqaarka, looshannada, iyo kaabitaanka afka.
Astaamaha Muhiimka ah:
- Daahirsanaanta: ≥99% (HPLC-shahaado, COA-dufcad-gaar ah ayaa la bixiyay)
- Qaabka Unugyada Molecular: C₉H₁₅N₃O₂S | Miisaanka Molecular: 229.3 g/mol
- Solubility: 125 mg/mL oo biyo ah (ultrasonic-caawiyay)
- Shahaadooyinka: Aan-GMO ahayn, Xasaasiyad-free, Vegan-saaxiibtinimo
2. Xakamaynta tayada & Habka HPLC
Hannaankayaga gorfaynta waxa uu la socda borotokoollada asaagii dib loo eegay:
- Tusaalaha Diyaarinta: 1 mL dhexdhexaad ah oo dhexdhexaad ah oo lagu kariyey 94 ° C 10 min, vortexed (1600 rpm / 30 min), centrifuged (10,000 × g / 5 min), oo lagu kaydiyaa -20 ° C haddii loo baahdo.
- Nidaamka HPLC: Dionex Ultimate 3000 oo wata software Chromeleon.
- Tiirka: Cortecs UPLC T3 (2.1 × 150 mm, 1.6 μm qaybo, cabbirka daloolka 120 Å) .
- Marxaladda Wareegta: Elution gradient laga bilaabo 0.1% formic acid ilaa 70% acetonitrile/0.1% formic acid, heerka socodka 0.3 mL/min.
- Ogaanshaha: nuugista UV ee 254 nm, LOQ 0.15 mmol/L.
Qiyaasaha Xaqiijinta:
- Linearity: 0.3-10 mmol/L (R²>0.99)
- Saxnimada: ≤6% RSD (Intra-/Inter-Asay)
- Soo kabashada: ~ 100% saxsanaan
3. Faa'iidooyinka Caafimaadka & Codsiyada
3.1 Isticmaalka Nafaqada
- Ilaalinta Mitochondrial: Waxay yaraynaysaa diiqada oksaydhka iyada oo la xoqdo radicals hydroxyl (IC₅₀: 2.5 μM) iyo anions superoxide.
- Taageerada Telomere: Waxay dib u dhigtaa telomere-ga la xidhiidha da'da oo gaabinaysa gudaha vitro .
- Qiyaasta: Daraasadaha kiliinikada waxay soo jeedinayaan 5-20 mg / maalin waxay sare u qaadeysaa heerarka plasma ERT si weyn.
Alaabta lagu taliyay:
- Kaabsoosha: 100 μg-5 mg halkii qaadasho (tusaale, LifeExtension's Essential Youth) .
- Isku-darka Isku-dhafka: Waxay ku biirtaa aashitada ferulic si loo wanaajiyo helitaanka noolaha.
3.2 Isticmaalka Cosmeceutical
- Ka-hortagga gabowga: Waxay joojisaa tyrosinase (40% dhimista 0.5% diiradda) waxayna ka ilaalisaa elastin hoos u dhaca UV.
- Tilmaamaha Samaynta:
- pH: 4.0-6.0 (dejinta ugu fiican)
- Xoog-saarista: 0.5-2.0% ee serums/lotions
- Waafaqid: Ku xasiloon fitamiin C, hyaluronic acid, iyo peptides.
4. Tilmaamaha Farsamada
| Halbeegga | Tilmaamid | Tixraac |
|---|---|---|
| Muuqashada | Budada crystalline cad | |
| Daahirnimada (HPLC) | ≥99% | |
| Meesha dhalaalaysa | 275-280°C (quruxsan) | |
| Kaydinta | 2-8°C weelka hawo-mareenka ah | |
| Nolosha shelf | 24 bilood |
5. Badbaadada & U Hogaansanaanta Xeerarka
- Xogta Badbaadada: LD₅₀>2000 mg/kg (afka, jiirka); wax saameyn xun kuma yeelan tijaabooyinka aadanaha .
- Shahaadooyinka: Ogolaanshaha Cunnada Cusub ee EU (Ergoneine®), FDA GRAS .
- Qabashada: Isticmaal neefsiyeyaasha ay ogolaatay NIOSH iyo galoofyada u adkaysta kiimikaad inta lagu jiro habaynta warshadaha.
6. Alaabta & Baakadaha Caalamiga ah
- Xulashada Baakadaha: 1 kg, 10 kg, 1000 kg (bacaha aluminium aluminium ah oo leh qallajiye) .
- Wakhtiga hogaaminta: 3-5 maalmood oo shaqo (rabin caalami ah oo loo maro DHL/FedEx) .
- Suuqyada loo adeego: USA, EU, Australia, Japan, Brazil .
7. Erayada Muhiimka ah
- Erayada muhiimka ah: "L-Ergothioneine 99%HPLC", "Antioxidant-ka Dabiiciga ah Bixiyaha", "Ergothioneine ee Daryeelka Maqaarka".
- Ku dar CAS 497-30-3, sheegashada daahirnimada, iyo shuruudaha codsiga.
