Beta-nicotinamide Mononucleotide (NMN), oo ah wax soo saarka falcelinta NAMPT iyo furaha NAD + dhexe, waxay hagaajisaa dulqaadka gulukooska iyadoo dib u soo celinaysa heerarka NAD + ee jiirarka T2D ee HFD.NMN waxay sidoo kale wanaajisaa dareenka insulin-ta ee beerka waxayna dib u soo celisaa muujinta hidda-wadaha ee la xidhiidha diiqada oksaydhka, jawaabta bararka, iyo laxanka wareegga, qayb ahaan iyada oo loo marayo firfircoonida SIRT1.NMN waxaa loo isticmaalaa in lagu barto motifs ku xiran gudaha RNA aptamers iyo hababka firfircoonida ribozyme ee ku lug leh β-nicotinamide mononucleotide (Beta-NMN) -firfircoonaanta RNA.
Nicotinamide mononucleotide ("NMN" iyo "β-NMN") waa nucleotide ka soo jeeda ribose iyo nicotinamide.Niacinamide (nicotinamide,) waa nooc ka mid ah fitamiin B3 (niacin.) Sida horudhac biochemical ee NAD+, waxaa laga yaabaa inay faa'iido u leedahay ka hortagga pellagra.
Qaabkeeda aan xoogga la saarin, niacin, waxaa laga helaa ilo nafaqo oo kala duwan: Lawska, Mushrooms (portobello, dubay), Avocados, digir cagaaran (cusub), iyo kalluunka iyo hilibka xoolaha qaarkood.
Daraasadaha [jiirarka], NMN waxay muujisay inay dib u celiso cillad la'aanta da'da ee la xiriirta da'da iyada oo la yareeyo cadaadiska oksaydhka.
Magaca: Beta-Nikotinamide Mononucleotide
CAS ： 1094-61-7
Magaca alaabta: Beta-Nicotinamide Mononucleotide;NMN
Magacyo kale: β-D-NMN; BETA-NMN; beta-D-NMN; NMN zwitterion; Nicotinamide Ribotide; Nicotinamide nucleotide, Nicotimide mononucleotide, Nicotinamide mononuclotide.
CAS: 1094-61-7
Qaaciddada molecular: C11H15N2O8P
Miisaanka Molecular: 334.22
daahirnimo:98%
Heerkulka Kaydinta: 2-8°C
Muuqaal: budo cad
Isticmaal: anti-gabowga
Shaqada:
1.Nicotinamide mononucleotide ee unugyada bini'aadamka waxay door muhiim ah ka ciyaaraan tamarta tamarta, waxay ku lug leedahay NAD intracellular (nicotinamide adenine dinucleotide, beddelka tamarta unugyada muhiimka ah koenzyme) synthesis, oo loo isticmaalo anti-gabowga, hoos u dhaca sonkorta dhiigga iyo alaabta kale ee daryeelka caafimaadka.
2. Nicotinamide Mononucleotide waa fiitamiin biyo-milmi leh, alaabtu waa budo crystalline cad, aan ur lahayn ama ku dhow ur, dhadhan qadhaadh, si xor ah ugu milmi biyaha ama ethanol, milma ee glycerin.
3.Nicotinamide Mononucleotide waa sahlan tahay in la nuugo afka, waxaana si ballaaran loogu qaybin karaa jirka, dheef-shiid kiimikaad ama prototype ayaa si dhakhso ah uga soo baxa kaadida.Nicotinamide waa qayb ka mid ah coenzyme I iyo coenzyme II, waxay ka ciyaartaa doorka bixinta hydrogen ee silsiladda neefsiga ee noolaha, waxay kor u qaadi kartaa hababka oksaydhka noolaha iyo dheef-shiid kiimikaadka nudaha, ilaalinta unugyada caadiga ah (gaar ahaan maqaarka, habka dheef-shiidka iyo habdhiska dareenka) daacadnimadu waxay leedahay door muhiim ah .
Intaa waxaa dheer, nicotinamide waxay leedahay ka-hortagga iyo daaweynta xannibaadda wadnaha, shaqada sanka sanka iyo arrhythmias-ka-hortagga tijaabada ah, nicotinamide waxay si weyn u wanaajin kartaa garaaca wadnaha iyo xannibaadda atrioventricular ee ay keento verapamil.
