Sialic acid budada

Sialic acid (SA), cilmi ahaan loo yaqaan "N-acetylneuramine", waa karbohaydrayt si dabiici ah u dhacda.Waxay asal ahaan ka go'day qanjidhada submandibular mucin, markaa magaca.Sialic acid waxay caadi ahaan ku jirtaa qaabka oligosaccharides, glycolipids ama glycoproteins.Jirka bini'aadamka, maskaxdu waxay leedahay maadada sialic acid ee ugu sareysa.Maadada sialic acid ee ku jirta maadada cawl waxay 15 jeer ka badan tahay xubnaha gudaha sida beerka iyo sambabada.Ilaha ugu muhiimsan ee sialic acid waa caanaha naaska, kaas oo sidoo kale laga helo caanaha, ukunta iyo farmaajada.

Daawada, glycolipids oo ay ku jiraan sialic acid waxaa loo yaqaan 'gangliosides', kuwaas oo door aad u muhiim ah ka ciyaara wax soo saarka iyo horumarinta maskaxda iyo habdhiska dareenka.Isla mar ahaantaana, daraasaadka xayawaanku waxay muujiyeen in hoos u dhigista heerarka ganglioside ay la xiriirto nafaqo-xumada hore iyo hoos u dhaca awoodda waxbarashada, halka kabidda sialic acid ay hagaajin karto dhaqanka barashada xayawaanka.Siyalic acid oo ku filan ayaa laga yaabaa inay si gaar ah muhiim ugu tahay horumarka caadiga ah ee shaqada maskaxda ee carruurta miisaankoodu hooseeyo.Ka dib dhalashada ilmaha, sialic acid ee caanaha naaska ayaa lagama maarmaan u ah si loo hubiyo korriinkooda caadiga ah.Baaritaanada ayaa muujiyay in heerarka sialic acid ee hooyooyinka ka dib dhalmada ay hoos u dhacaan waqti ka dib.Sidaa darteed, qaadashada joogtada ah ee qadar ku filan sialic acid inta lagu jiro uurka iyo uurka ka dib waxay kaa caawin kartaa ilaalinta heerarka sialic acid ee jirka.Intaa waxaa dheer, maadada sialic acid waxay sidoo kale si weyn ugu xiran tahay nuxurka DHA, taasoo soo jeedinaysa inay aad ugu dhowdahay inay la xiriirto qaab dhismeedka maskaxda iyo horumarinta shaqada maskaxda ee dhallaanka, labaduba waxay faa'iido u yeelan karaan horumarinta maskaxda hore.

Daraasaduhu waxay muujiyeen in muddada dahabiga ah ee koritaanka maskaxda bini'aadamku ay u dhexeyso da'da 2 iyo 2 da'da.Marxaladani waa xilli aad muhiim u ah hagaajinta lambarka unugyada maskaxda, korodhka mugga, dhammaystirka shaqada, iyo samaynta shabakada neerfaha.Sidaa darteed, hooyooyinka caqli badan waxay si dabiici ah u fiirsan doonaan qaadashada qadar ku filan oo ah sialic acid xilliga uurka.Ka dib marka ilmuhu dhasho, caanaha naaska ayaa ah hab wax ku ool ah oo loogu daro sialic acid ilmaha, sababtoo ah qiyaastii 0.3-1.5 mg sialic acid halkii millilitir ee caanaha naaska.Dhab ahaantii, dhammaan naasleyda, oo ay ku jiraan bini'aadamka, ayaa awood u leh inay keligood ka soo saaraan sialic acid beerka.Si kastaba ha ahaatee, korriinka beerka ee dhallaanka dhashay weli ma qaangaarin, baahida korriinka degdega ah iyo korriinka maskaxda ayaa laga yaabaa inay xaddiddo isku-darka sialic acid, gaar ahaan dhallaanka dhicis ah.Sidaa darteed, sialic acid ee ku jirta caanaha naaska ayaa lagama maarmaan u ah hubinta koritaanka caadiga ah iyo koritaanka ilmaha.
Cilmi-baarayaasha Australiyaanka ah ayaa ogaaday in dhallaanka naaska la nuujiyo ay ku badan yihiin kiliyaha hore ee sialic acid marka loo eego dhallaanka caanaha la nuujiyo.Tani waxay kor u qaadi kartaa samaynta synapses, ka caawinta xusuusta ilmaha si ay u sameeyaan saldhig dhismeed oo xasilloon, iyo xoojinta horumarinta habdhiska dareenka.

Waa maxay Sialic acid

Sialic acidwaa koox ka mid ah derivatives of neuraaminic acid (N- ama O-bedelay derivatives neuraaminic acid).Caadi ahaan qaabka oligosaccharides, glycolipids ama glycoproteins.

Sialic acidsidoo kale waa magaca xubinta ugu caansan kooxdan - N-acetylneuramine (Neu5Ac ama NANA).

Qoyska Sialic acid

Waxaa lagu yaqiinay ku dhawaad ​​50 xubnood, dhammaan waxyaabaha ka soo jeeda 9-kaarboon ee sokorta neuraminic acid.

N-acetylneuramine (Neu5Ac), N-glycolylneuramine

aashitada (Neu5Gc) iyo deaminoneuramine (KDN) waa monomer xudunta u ah.

N-acetylneuraminic acid waa nooca kaliya ee Sialic acid ee jidhkeena.

Sialic acid iyo buulka shimbiraha

Sababtoo ah Sialic acid waxay qani ku tahay buulka shimbiraha, waxaa sidoo kale loo yaqaannaa aashitada buulka shimbiraha, taas oo ah calaamad lagama maarmaan u ah qiimeynta buulka shimbiraha.

Sialic acid waa maaddooyinka nafaqada ugu muhiimsan ee buulka shimbiraha, qiyaastii 3%-15% miisaan ahaan.

Dhammaan cuntooyinka la yaqaan, buulka shimbirku waxa ku jira maadada ugu badan ee Sialid acid, oo 50 jeer ka sarraysa cuntooyinka kale.

1g buul shimbireedku wuxuu la mid yahay 40 ukun haddii aynu helno tiro isku mid ah oo Sialic acid ah.

Ilaha cuntada Sialic acid

Guud ahaan, dhirtu kuma jiraan Sialic acid.Sahayda ugu horeysa ee Sialic acid waa caanaha dadka, hilibka, ukunta, iyo farmaajo.

Nuxurka wadarta Sialic acid ee cuntooyinka caadiga ah (µg/g ama µg/ml).

Waxaan arki karnaa in Sialic acid-ka ku jira caanaha bini'aadamka ay sarreeyaan, taas oo ah maaddada furaha u ah korriinka maskaxda ilmaha.

Laakiin waxa ku jira Sialic acid way ku kala duwan yihiin xilliyada kala duwan ee caanaha dadka

Dambarka caanaha naaska 1300 +/- 322 mg/l

10 maalmood ka dib 983 +/- 455 mg/l

Budada caanaha dhallaanka ka hor 197 +/- 31 mg/l

Caanaha la habeeyey 190 +/- 31 mg/l

Noocyada caanaha ee qayb ahaan la habeeyey 100 +/- 33 mg/l

Caano la-socod 100 +/- 33 mg/l

Caanaha ku salaysan soy 34 +/- 9 mg/l

Marka la barbardhigo caanaha naaska, budada caanaha dhallaanku waxay ka kooban tahay 20% Sialic acid oo laga helo caanaha bini'aadamka, halka ilmuhu uu ka heli karo oo kaliya 25% Sialic acid caanaha naaska.

Ilmaha aan dhalan, Sialic acid aad ayuu uga muhiimsan yahay ilmaha caafimaadka qaba ee korriinka Maskaxda.

Daraasada Sialic acid ee ku saabsan budada caanaha

"Natiijooyinka waxay muujiyeen in maadada sialic acid maskaxda ay door muhiim ah ka qaadato go'aaminta dabeecadda.Koox kale waxay arkeen barashada horumarsan ee daawaynta sialic acid ee bilaashka ah ee jiirka."

Dib u eegida CAB: Aragtiyada Beeraha, Sayniska Xoolaha, Nafaqada, iyo Dabiiciga ah

Khayraadka 2006 1, No. 018, Sialic acid ma ugu jirtaa cuntada caanaha maskaxda?, Bing Wang

"Gabagabada waa maskaxda sare ee ganglioside iyo glycoprotein sialic acid uruurinta dhallaanka la quudiyo caanaha bini'aadamka waxay soo jeedinaysaa kororka synaptogenesis iyo kala duwanaanshaha horumarinta neurodevelopment."

Am J Clin Nutr 2003;78:1024–9.Lagu daabacay USA.© 2003 Bulshada Maraykanka ee Nafaqada Caafimaadka, Maskaxda ganglioside, iyo glycoprotein sialic acid ee naaska la nuujiyo marka la barbar dhigo dhallaanka caanaha la nuujiyo, Bing Wang

"Xubabka unugyada neerfaha waxaa ku jira 20 jeer in ka badan sialic acid marka loo eego noocyada kale ee xuubka, taas oo muujinaysa in sialic acid ay door cad ku leedahay dhismaha neerfaha."

Joornaalka Yurub ee Nafaqada Caafimaadka, (2003) 57, 1351-1369, Doorka iyo kartida sialic acid ee nafaqada aadanaha, Bing Wang

Codsiga N-Acetylneuramine

Budada caanaha

Hadda, Budada caanaha hooyada naaska nuujinaysa oo aad iyo aad u badan, budada caanaha dhallaanka, iyo kaabayaasha nafaqada waxa ku jira Sialic Acid suuqa.

Hooyooyinka Naaska nuujiya

Loogu talagalay budada caanaha ilmaha 0-12 bilood

Loogu talagalay alaabta daryeelka caafimaadka

Cabitaanka

Maadaama Sialic acid uu leeyahay awood wanaagsan oo biyaha lagu milmi karo, shirkado badan ayaa isku dayaya inay horumariyaan cabitaannada Sialic acid ee caafimaadka Maskaxda ama ku dara waxyaabaha caanaha laga sameeyo.

Badbaadada N-Acetylneuramine

N-Acetylneuraminic acid aad buu u badbaado.Hadda, wax war xun ah lagama soo sheegin Sialic acid.

Maraykanka, Shiinaha, iyo dawladaha EU waxay ogolaadeen Sialic acid in loo isticmaalo alaabta daryeelka caafimaadka iyo cuntada.

USA

Sannadkii 2015, N-Acetyl-D-neuraminic acid (Sialic acid) ayaa loo aqoonsaday Guud ahaan Badbaado (GRAS)

Shiinaha

Sannadkii 2017, Dawladda Shiinuhu waxay ansixisay N-Acetylneuraminic acid sida Walax Cunno oo Cusub.

EU

Badbaadada N-acetyl-d-neuraminic acid-ka-soo-saarka sida cunno cusub oo hoos timaada Xeerka (EC) Maya 258/97

Markay ahayd 16 Oktoobar 2015, magacaabista agoonta (EU/3/12/972) waxaa siiyay Komishanka Yurub ee Ultragenyx UK Limited, Boqortooyada Ingiriiska, sialic acid (sidoo kale loo yaqaan aceneuramic acid) daaweynta GNE myopathy.

Fikradda Sayniska ah ee caddaynta sheegashooyinka caafimaadka ee la xidhiidha sialic acid iyo barashada iyo xusuusta (ID 1594) iyada oo la raacayo Qodobka 13(1) ee Xeerka (EC) Maya 1924/2006

Qiyaasta

CFDA waxay soo jeedinaysaa 500mg/maalintii

Cunto cusub waxay soo jeedinaysaa 55mg/maalintii dhallaanka iyo 220mg/maalintii haweenka da'da yar iyo kuwa dhexe

N-acetylneuramine function

Horumarinta xusuusta iyo garaadka

Iyadoo la falgasha xuubabka unugyada maskaxda iyo synapses, Sialic acid waxay kordhisaa heerka jawaabta synapses ee unugyada dareemayaasha maskaxda, taas oo kor u qaadeysa horumarinta xusuusta iyo garaadka.

Saynis yahanada New Zealand ayaa sameeyay tijaabooyin taxane ah si ay u xaqiijiyaan doorka muhiimka ah ee aysiidhka buulka shimbiruhu ku leeyihiin horumarka garaadka carruurta.Ugu dambayntii, cilmi-baarayaashu waxay ku soo gabagabeeyeen in kaabista asiidhka buulka shimbiraha ee dhallaanka ay kordhin karto isku-ururinta asiidhka buulka shimbiraha ee maskaxda, taas oo kor u qaadaysa awoodda maskaxda ee wax-barashada.

Hagaajinta awoodda nuugista mindhicirka

Marka loo eego ifafaalaha jireed ee fudud ee jinsiga ka soo horjeeda, macdanta si togan loo soo dallaco iyo fiitamiinnada qaar ee gala mindhicirka ayaa si fudud loogu daraa aashitada buulka shimbiraha ee xoogga leh ee taban, sidaa darteed nuugista xiidmaha ee fiitamiinnada iyo macdanta.Awoodda ayaa laga soo qaaday.

Kor u qaad ka saarista bakteeriyada bakteeriyada xiidmaha

Sialic acid oo ku jirta borotiinka xuubka unuggu wuxuu door muhiim ah ka ciyaaraa hagaajinta awooda aqoonsiga unugga, sunta sunta daacuunka, ka hortagga caabuqa Escherichia coli ee cudurada, iyo nidaaminta borotiinka dhiiga nuska nolosha.

Cimri dheer

Sialic acid waxay leedahay saameyn difaac iyo xasilinta unugyada, iyo la'aanta sialic acid waxay u horseedi kartaa hoos u dhaca nolosha unugyada dhiigga iyo hoos u dhaca dheef-shiid kiimikaadka glycoprotein.

U samee dawo cusub Sialic Acid

Saynis yahanadu waxay isku dayaan inay ku daweeyaan cudurada caloosha iyo mindhicirka iyagoo isticmaalaya dawooyinka ka hortagga adhesion ee sialic acid.Daawooyinka ka hortagga xabagta ee Sialic acid waxay daweyn karaan Helicobacter pylori si ay u daweeyaan boogaha gastric iyo boogaha duodenal.

Sialic acid waa glycoprotein.Waxay go'aamisaa aqoonsiga wadajirka ah iyo isku xirnaanta unugyada waxayna leedahay saameyn caafimaad oo la mid ah aspirin.

Sialic acid waa daawo loogu talagalay cudurrada dhexe ama kuwa jirka la mariyo iyo cudurrada demyelinating;sialic acid sidoo kale waa qufaca rajada.

Sialic acid oo ah walxo ceeriin ah waxay soo saari kartaa taxane ah dawooyinka sonkorta muhiimka ah, anti-virus, anti-buro, anti-bararka, iyo daawaynta waallida waayeelka waxay leeyihiin natiijooyin aad u fiican.

Habka wax soo saarka ee Sialic Acid

Alaabta ceeriin ee bilawga ah waxay u badan tahay gulukooska, khamriga galleyda, glycerin, iyo magnesium sulfate.Oo waxaan isticmaalnaa tignoolajiyada khamiirsan.Inta lagu jiro habkan, waxaan isticmaalnaa habka jeermiska si aan u ilaalino alaabta nadiifka ah.Dabadeed by hydrolysis, fiirsashada, qalajinta, iyo burburinta.Dhammaan hababka, waxaan helnaa badeecada ugu dambeysa.QC-na waxay isticmaali doontaa HPLC si ay u tijaabiso tayada agabka dufcad kasta ka hor inta aanan u gudbin macaamiisha.

Magaca badeecada: Sialic acid;N-Acetylneuramine

Magaca kale:5-Acetamido-3,5-dideoxy-D-glycero-D-galactonulosonic acid o-Sialic acid Galactononulosonic acid Lactaminic acid NANA N-Acetylsialic acid

Asal: Buul shimbireed la cuni karo
Gaar ahaan: 20%-98%
Muuqaalka: budo cad oo cad
CAS NO.: 131-48-6
MW: 309.27
MF: C11H19NO9

Meesha Asal ahaan: Shiinaha

Kaydinta: Ku kaydi meel qabow & qalalan, ka fogow iftiinka tooska ah iyo kulaylka.
ansaxnimada: Laba sano haddii si fiican loo kaydiyo.

SHAQADA:

1. Shaqada ka hortagga fayraska.
2. Shaqada ka hortagga kansarka.
3. Shaqada ka hortagga caabuqa.
4. Shaqada difaaca ee caabuqa bakteeriyada.
5. Xakamaynta awoodda habka difaaca jirka.
6. Awoodda xakamaynta midabaynta.
7. Isbeddelka calaamadaha unugyada dareemayaasha.
8. Door muhiim ah ka ciyaar horumarinta maskaxda iyo waxbarashada.
9. Sida horudhac u ah soo saarista dawooyin badan oo dawooyin ah.