Azelaic Acid 98%ka HPLC | Pharmaceutical & Cosmetic Grade
1. Tlhaloso ea Sehlahisoa
Asiti ea Azelaic(CAS123-99-9) ke tlhaho ea tlhaho ea dicarboxylic acid e nang le foromo ea molek'hule C₉H₁₆O₄ le boima ba molek'hule 188.22 g/mol. Kereiti ea rona ea bohloeki e netefalitsoeng ke 98% e kopana le litekanyetso tsa USP/EP, tse ntlafalitsoeng bakeng sa metsoako ea letlalo le lits'ebetso tsa indasteri.
Litlhaloso Tse Bohlokoa
- Bohloeki: ≥98% (HPLC-ELSD e netefalitsoeng, litšila tsohle <0.2%)
- Ponahalo: Phofo e tšoeu ea kristale
- Sebaka se qhibilihang: 109-111°C
- Sebaka se belang: 286°C ho 100 mmHg
- Sollubility: 2.14 g/L metsing (25°C), e qhibiliha ka har'a metsoako ea ethanol/alkaline
2. Sebopeho sa Lik'hemik'hale
2.1 Netefatso ea Sebopeho
- Boemo ba NMR:
¹H NMR (300 MHz, CDCl₃): δ 1.23 (t, J=7.1Hz, 3H), 1.26-1.39 (m, 6H), 1.51-1.69 (m, 4H), 2.26/2.32 (q, 4.10 Hz), e 'ngoe le e 'ngoe s, COOH) - HPLC Chromatogram:
Nako ea ho Boloka: 20.5 min (tlhōrō e kholo), litlhōrō tsa ho se hloeke <0.1% ho 31.5 / 41.5 min
2.2 Protokhole ea Taolo ea Boleng
| Paramethara | Mokhoa | Mekhoa ea ho Amohela |
|---|---|---|
| Tlhahlobo | HPLC-ELSD (Agilent 1200) Kholomo: Purospher Star RP-C18 Mobile Phase: Methanol/Metsi/Acetic Acid gradient | 98.0-102.0% |
| Litšepe tse boima | ICP-MS | ≤10 ppm |
| Metsoako e setseng | GC-FID (kholomo ea HP-5MS) Derivatization le HMDS | Ethanol <0.5% |
3. Lisebelisoa tsa Meriana
3.1 Katleho ea Dermatological
- Lefu la Vulgaris:
E fokotsa li-comedone ka 65% litekong tsa libeke tse 12 (20% cream) ka:- Ketso ea antimicrobial khahlano leC. li-acne(MIC₅₀ 256 μg/mL)
- Thirosinase inhibition (IC₅₀ 3.8 mM) bakeng sa hyperpigmentation ea ka mor'a ho ruruha
- Rosacea:
15% ea gel e bonts'a phokotso ea 72% ea erythema (vs 43% placebo) ka:- Antioxidant ROS scavenging (EC₅₀ 8.3 μM)
- Khatello ea MMP-9 ho keratinocyte
3.2 Litaelo tsa Tlhahiso
| Foromo ea litekanyetso | E khothaletsoa % | Litlhaloso tsa ho lumellana |
|---|---|---|
| Cream/Gel | 15-20% | Qoba methylparaben (e baka ho senyeha ha 42%) |
| Liposomal | 5-10% | Sebelisa phosphate buffer pH7.4 + lecithin ea soya |
4. Cosmetic Applications
4.1 Synergy ea Whitening
- Motsoako o nepahetseng:
- 2% AzA + 5% Vithamine C: 31% ea ho fokotsa melanin vs monotherapy
- 1% AzA + 0.01% Retinol: 2x collagen synthesis boost
4.2 Boitsebiso ba Botsitso
| Boemo | Sekhahla sa ho senyeha |
|---|---|
| 40°C/75% RH (3M) | <0.5% |
| Tšusumetso ea UV | 1.2% (ka ts'ireletso ea TiO₂) |
5. Tšebeliso ea Liindasteri
- Polymer Precursor:
- Motsoako oa nylon-6,9 (kotulo ea karabelo> 85% ho 220°C)
- Corrosion inhibitor bakeng sa li-alloys tsa tšepe (tharollo ea 0.1M e fokotsa ho bola ka 92%).
6. Polokeho & Taolo
6.1 Boemo ba Toxicological
| Paramethara | Sephetho |
|---|---|
| Acute Oral LD₅₀ (Rat) | > 5000 mg/kg |
| Ho teneha ha Letlalo | Ha bonolo (OECD 404) |
| Kotsi ea Ocular | Sehlopha sa 2B |
6.2 Tumellano ea Lefatše
- Setifikeiti:
- US FDA Lithethefatsi Master File
- EU REACH E ngolisitsoe
- ISO 9001: Sistimi ea Boleng ea 2015
7. Packaging & Storage
| Bongata | Setshelo | Theko (EXW) |
|---|---|---|
| 25 kg | Moropa oa HDPE + mokotla oa Alu | $4,800 |
| 1 kg | Botlolo ea khalase ea Amber | $220 |
| 100 g | Mokotla o tiisitsoeng habeli | $65 |
Sebaka sa polokelo: 2-8°C sebakeng se omileng (mocheso oa kamore o amoheleha haeba <25°C/60% RH)
8. Lipotso-potso
P: A na nka sebelisa azelaic acid ka niacinamide?
A: E, lintlha tsa kliniki li bontša 10% AzA + 4% niacinamide e ntlafatsa mamello 37% vs AzA feela
P: Shelf bophelo ke eng?
A: Likhoeli tse 36 ha li bolokiloe hantle. Ho fanoe ka COA e khethehileng ka sehlopha
9. Litšupiso
- Lintlha tsa sebopeho sa NMR
- Mokhoa oa HPLC-ELSD
- Lithuto tsa botsitso
- Katleho ea bongaka
