Lebitso la Sehlahisoa:YDL223C (HBT1) Phofo

Lebitso le Leng:HBT1,YDL223C

CASNo:489408-02-8

Litlhaloso:99.0%

Mmala:Bosehla bo kganyang bo tiilenge nang le monko le tatso e ikhethang

GMOBoemo: GMO Mahala

Ho paka: ka meqomo ea fiber ea 25kgs

Polokelo: Boloka setshelo se sa buloa sebakeng se phodileng, se omileng, Qoba hole le leseli le matla

Shelf Life: Likhoeli tse 24 ho tloha ka letsatsi la tlhahiso

HBT1 ke molek'hule e ka tlamang feela sebakeng se itseng ho protheine ea AMPA-R ha glutamate e le teng, 'me tlamahano ena e thusa ho laola tšebetso ea protheine. Li-receptor tsa AMPA li hlahisoa ho pholletsa le tsamaiso ea methapo e bohareng 'me li phetha karolo ea bohlokoa puisanong ea neuronal, ts'ebetso ea kutlo, ho ithuta, mohopolo le polasetiki ea synaptic. Li-receptor tsa AMPA ke tsona tse kenyang letsoho ho pharalletseng ha methapo ea kutlo, li kenella ka potlako, ka potlako, li nyahamisa maikutlo ho li-synapse tse ngata, 'me li kenya letsoho likarabelong tsa pele tsa glutamate libakeng tsa synaptic. Hangata li-receptor tsa AMPA li hlahisoa ka kopanelo le li-receptor tsa NMDA ho li-synapse, 'me hammoho li khothaletsa lits'ebetso tsa polasetiki tsa synaptic tse amehang ho ithuteng, mohopolong, ho excitotoxicity le neuroprotection. Boko-derived neurotrophic factor (BDNF) ke neurotrophic factor e phethang karolo ea bohlokoa tlhokomelong le katolosong ea methapo ea kutlo 'me e na le liphello tse matla le tse ngata ho atang, ho khetholla, ho phela le lefu la lisele tsa neuronal le tse seng tsa neuronal. , modulator ea li-neurotransmitter e tlatsetsang ho polasetiki ea neuronal thutong le mohopolong. Ka hona, e bohlokoa bakeng sa bophelo bo botle le boiketlo ba tsamaiso ea methapo.

Mesebetsi:

1. Yeast genomic knockout strain
   2. Shmoo tip protheine, substrate ea Hub1p ubiquitin-like protheine; Liphetoho li na le phoso bakeng sa sebopeho sa ho nyalana, ka hona
   ho kenyelletsa Hbt1p ho polarized cell morphogenesis; HBT1 e na le paralog, YNL195C, e hlahileng phetisong eohle ea liphatsa tsa lefutso
   3. E sebelisoa tšimong ea meriana.
   4. Ntlafatsa bohlale ba kelello.
   5. Matlafatsa mohopolo le bokhoni ba ho itšetleha.
   6. Ntlafatsa boemo ba tšusumetso.
   7. Ntlafatsa taolo ea mochine oa boko ba cortical / subcortical.
   8. Ntlafatsa temoho ea kutlo.
   9. Ntlafatsa matla a boko ho rarolla mathata le ho a sireletsa lik'hemik'hale leha e le life kapa 'mele.

Lisebelisoa:

HBT1 ke buka e matla ea AMPA-R [alpha-amino-3-hydroxy-5-methyl-4-isoxazole-propionic acid (AMPA) receptor] potentiator e nang le phello e tlase ea agonistic ha e bapisoa le LY451395 le OXP1, e susumetsa tlhahiso ea boko bo nkiloeng. neurotrophic factor (BDNF) mme e bonts'a phello e nyane ea agonistic ho li-neurone tsa mantlha. HBT1 e tlamella sebakeng se tlamang ligand sa AMPA-R ho manne e itšetlehileng ka glutamater