Igama lemveliso:1,4-DihydronicotinaMide Riboside
Elinye Igama:I-1,4-DIHYDRONICOTINAMIDE I-RIBOSIDE1-[(3R,4S,5R)-3,4-dihydroxy-5-(hydroxymethyl)oxolan-2-yl]-1,4-dihydropyridine-3-carboxamid eSCHEMBL188493711-[(3R,4S,5R)-3,4-DIHYDROXY-5-(HYDROXYMETHYL)OXOLAN-2-YL]-4H-PYRIDINE-3-CARBOXAMIDE
Inombolo yeCAS:19132-12-8
Iinkcukacha: 98.0%
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I-1,4-dihydronicotinamide riboside, eyaziwa ngokuba yi-NRH.Uhlobo oluncitshisiweyo lwe-NRH luyi-precursor ye-NAD + enamandla enceda ukuzalisa amanqanaba ayo kwiseli.
I-1,4-dihydronicotinamide riboside, eyaziwa ngokuba yi-NRH.Uhlobo oluncitshisiweyo lwe-NRH luyi-precursor ye-NAD + enamandla enceda ukuzalisa amanqanaba ayo kwiseli.
Okokuqala nokuphambili, kubalulekile ukuqonda indima ye-NAD + emzimbeni. I-NAD + yi-coenzyme ebandakanyeka kwiinkqubo ezininzi zeselula, kubandakanya amandla e-metabolism, ukulungiswa kwe-DNA, kunye nokubonakaliswa kofuzo. Njengoko sikhula, amanqanaba ethu e-NAD + ehla, ethe yabandakanyeka kwinkqubo yokuguga kunye nezifo ezinxulumene neminyaka. Oku kukhokelele kumdla okhulayo wokuchonga iimolekyuli ezinokonyusa amanqanaba e-NAD + emzimbeni, kwaye i-1,4-dihydronicotinamide riboside yenye molekyuli.
I-1,4-dihydronicotinamide riboside yi-precursor ye-NAD+ enamandla, kwaye uphando lubonise ukuba inokunyusa ngokufanelekileyo amanqanaba e-NAD + kwiiseli. Oku kukhokelele kuqikelelo lokuba i-1,4-dihydronicotinamide riboside supplementation inokuba namandla onyango kuluhlu olubanzi lweemeko zempilo, kubandakanya ukuphazamiseka kwemetabolism, izifo ze-neurodeergenerative, kunye nokwehla okunxulumene nokwaluphala.
Ngapha koko, kukho ubungqina bokucebisa ukuba i-1,4-dihydronicotinamide riboside inokusebenza ngakumbi kuneamolekyuli yomzali wayo, i-nicotinamide riboside, ekunyuseni amanqanaba e-NAD +. Oku kungenxa yokuba i-1,4-dihydronicotinamide riboside sisinciphisi esinamandla ngakumbi, okuthetha ukuba kungcono ukunikela ngee-electron kwi-NAD+ synthesis pathway. Ngenxa yoko, inamandla okuvelisa ngokufanelekileyo i-NAD + yeselula.
Ukongeza kwindima yayo kwi-NAD+ biosynthesis, i-1,4-dihydronicotinamide riboside nayo ineempawu ze-antioxidant. Uxinzelelo lwe-oxidative, olubangelwa kukungalingani phakathi kweeradicals zasimahla kunye ne-antioxidants emzimbeni, luchaphazeleka kwizifo ezininzi, kubandakanya umhlaza, isifo sentliziyo, kunye nokuphazamiseka kwe-neurodeergenerative. Ngokukhupha ii-radicals zasimahla kunye nokunciphisa umonakalo owenziwe nge-oxidative, i-1,4-dihydronicotinamide riboside inokubonelela ngeenzuzo ezongezelelweyo zempilo ngaphaya kwendima yayo njenge-NAD+ isandulela.
