Igama lemveliso:YDL223C (HBT1) Umgubo

Elinye Igama:HBT1,YDL223C

CASNo:489408-02-8

Iinkcukacha:99.0%

Umbala:Ukukhanya okuqinileyo okutyhelienevumba elibonakalayo kunye nencasa

GMOIsimo:GMO Mahala

Ukupakisha: kwi-25kgs fiber drums

Ugcino: Gcina isikhongozeli singavulwanga kwindawo epholileyo neyomileyo, Zigcine kude nokukhanya okuqinileyo

Ubomi beShelf: iinyanga ezingama-24 ukusuka kumhla wokuvelisa

I-HBT1 yimolekyuli enokuthi ibophe kuphela kwindawo ethile kwiprotheni ye-AMPA-R xa i-glutamate ikhona, kwaye oku kudibanisa kunceda ukulawula umsebenzi weprotheni. Ama-receptors e-AMPA abonakaliswa kuyo yonke inkqubo ye-nervous central kwaye adlale indima ebalulekileyo kunxibelelwano lwe-neuronal, ukusetyenzwa kweenzwa, ukufunda, imemori, kunye ne-synaptic plasticity. I-AMPA i-receptors inegalelo elikhulu kwi-neurotransmission evuselelayo, i-mediate ngokukhawuleza, ngokukhawuleza yenza ukuba i-synapses ikhuphe ngokukhawuleza, kwaye ibandakanyeka kwiimpendulo zakwangoko kwi-glutamate kwimimandla ye-synaptic. Ama-receptors e-AMPA ahlala edityaniswa kunye ne-NMDA receptors kwii-synapses, kwaye kunye zikhuthaza iinkqubo zeplastiki ze-synaptic ezibandakanyeka ekufundeni, imemori, i-excitotoxicity, kunye ne-neuroprotection. I-brain-derived neurotrophic factor (BDNF) i-neurotrophic factor edlala indima ebalulekileyo ekugcinweni nasekukhuliseni i-neurons kwaye ineempembelelo ezinamandla kunye neempembelelo ezininzi ekwandeni, ukwahlula, ukusinda kunye nokufa kweeseli ze-neuronal kunye ne-non-neuronal. , i-modulator ye-neurotransmitter enegalelo kwi-neuronal plasticity ekufundeni nakwimemori. Ngoko ke, ibalulekile kwimpilo kunye nokuphila kakuhle kwenkqubo ye-nervous.

Imisebenzi:

1. Igwele loxinzelelo lwe-genomic knockout
   2. Shmoo tip protein, substrate of Hub1p ubiquitin-like protein; iinguqu eziguqukileyo zineziphene ekwenziweni kwentelekelelo yokukhwelana
   ukubandakanya i-Hbt1p kwi-polarized cell morphogenesis; I-HBT1 ineparalog, YNL195C, evele kulo lonke uphindo lwegenome
   3. Isetyenziswa kwinkalo yamayeza.
   4. Ukuphucula ubukrelekrele bengqondo.
   5. Khulisa inkumbulo kunye nezakhono zokuthembela.
   6. Ukuphucula inqanaba lenkuthazo.
   7. Ukuphucula ulawulo lwe-cortical / subcortical brain mechanism.
   8. Phucula ingqiqo yeemvakalelo.
   9. Ukuphucula amandla engqondo ukusombulula iingxaki kunye nokukhusela kuyo nayiphi na ikhemikhali okanye yomzimba.

Usetyenziso:

I-HBT1 iyinoveli enamandla ye-AMPA-R [alpha-amino-3-hydroxy-5-methyl-4-isoxazole-propionic acid (AMPA) receptor] receptor enempembelelo ephantsi ye-agonistic xa kuthelekiswa ne-LY451395 kunye ne-OXP1, yenza ukuveliswa kwengqondo. I-neurotrophic factor (BDNF) kwaye ibonisa umphumo omncinci we-agonistic kwii-neurons eziphambili. I-HBT1 ibophelela kwi-ligand-binding domain ye-AMPA-R kwi-glutamate exhomekeke kwi-manner