Igama lemveliso:I-Galantamine Hydrobromide
Elinye Igama:iGalanthamine hydrobromide;Galantamine HBr; I-Galanthamine HBr;(4aS,6R,8aS)-4a,5,9,10,11,I-12-hexahydro-3-methoxy-11-methyl-6H-Benzofuro[3a,3,IHydrobromide
INOMBOLO YECAS:1953-04-4
Iinkcukacha:98.0%
Umbala:Mhlopheumgubo onevumba elibonakalayo kunye nencasa
Isimo se-GMO:GMO Mahala
Ukupakisha: kwi-25kgs fiber drums
Ugcino: Gcina isikhongozeli singavulwanga kwindawo epholileyo neyomileyo, Zigcine kude nokukhanya okuqinileyo
Ubomi beShelf: iinyanga ezingama-24 ukusuka kumhla wokuvelisa
I-Galantamine isetyenziselwa ukunyanga isifo se-Alzheimer esiphakathi ukuya kwi-Alzheimer kunye nezinye izithintelo zememori, ngakumbi ezo zemvelaphi ye-vascular. Yialkaloid efunyanwa ngokwenziwa okanye kwiibhalbhu kunye neentyatyambo zeGalanthus Caucasicus (iCaucasian snowdrop, iVoronov's snowdrop), iGalanthus woronowii (Amaryllidaceae) kunye negenera ehambelana nayo njengeNarcissus (daffodil)), iLeucojum(ikhephu leqhwa elibandakanya iLyflake) Red Spider Lily).
I-Galanthamine yendalo itsalwe kwi-lycoris radiate, yi-alkaloid ephezulu ephuma kwikhephu kunye neentlobo ezinxulumene ngokusondeleyo. Isebenza njenge-reversible competitive acetylcholinesterase (ACHE) inhibitor, ngelixa isebenza buthathaka kwi-butyrylcholinesterse (BuChE) .isetyenziselwa ukunyanga ukuphazamiseka kwenkqubo ye-nerbous ephakathi kwaye ingasetyenziselwa njenge-antidote kwi-relaxation ye-muscle engapholi. mhlophe ukuya phantse kumgubo omhlophe; ukunyibilika kancinci emanzini; i-chloroform enganyibilikiyo, i-ether kunye notywala .
I-Galantamine hydrobromide yi-benzazepine ephuma kwiibhalbhu kunye neentyatyambo ze-narcissus, i-osmanthus, okanye i-canna. Kwakhona i-oral cholinesterase inhibitor. Njenge-ligand ye-nicotinic acetylcholine receptors, isetyenziswe ngokubanzi ukuphucula umsebenzi we-neurocognitive. Umsebenzi wayo kukukhuphisana kunye nokubuyisela umva i-acetylcholinesterase, ngaloo ndlela inyusa ukuxinwa kwe-acetylcholine. Xa ifunxelwa egazini, igalantamine hydrobromide ifunxwa lula kwiindawo ezahlukahlukeneyo zomzimba, kuquka nengqondo. Ibophelela kwi-nicotinic acetylcholine receptors, ebangela utshintsho oluhambelanayo kunye nokwandisa ukukhululwa kwe-acetylcholine. Ikwasebenza ngokukhuphisana kunye nokuguqula imiphumo ye-cholinesterase inhibitors. Ngokuthintela i-cholinesterase, ikhusela ukuchithwa kwe-acetylcholine, ngaloo ndlela ikwandisa amanqanaba kunye nobude be-neurotransmitter enamandla. I-Galantamine inokuphucula ukufunda kunye nenkumbulo, ithintele ukudumba kwengqondo, kwaye igcine amanqanaba aphezulu ee-neurotransmitters ngokugcina ingqibelelo ye-neurons kunye ne-synapses.
Umsebenzi:
(1) Anti-cholinesterase .
(2) Ukuvuselela kunye nokuvimbela i-acetylcholinesterase, lawula indawo ye-intracephalic nicotine receptor.
(3) Uphilisa i-infantile paralysis sequelae, i-sweeny kunye ne-myasthenia gravis pseudoparalytica, njl.
(4) Ukuphucula umsebenzi wokuqaphela ukukhanya, izigulane ze-Alzheimer ezinobulali kakhulu, kunye nokulibazisa inkqubo yokuncipha komsebenzi weeseli zengqondo.
(5) Ukuphucula ukuqhuba phakathi kwe-nerve kunye ne-muscle.
Isicelo
1. IgalanthamineIHydrobromideisetyenziswa kakhulu kwi-myasthenia gravis, i-poliovirus quiescent stage kunye ne-sequela, kwakhona kwi-polyneuritis, i-funiculitis kunye ne-sensor barrier ebangelwa yi-nervous system disease okanye traumatism;
2. I-Galanthamine Hydrobromide iphinda isetyenziswe kwi-Alzheimer's disease, inomsebenzi oyintloko we-dement kunye ne-dysmnesia ebangelwa umonakalo wengqondo yezinto eziphilayo.
