I-Arachidonoyl Ethanolamide, i-arachidonoylethanolamide, i-N-arachidonoylethanolamine, kunye ne-AEA zonke zilingana ne-anandamide ngokwayo.Ngendlela, (5Z,8Z,11Z,14Z)-N-(2-hydroxyethyl)icosa-5,8,11,14-tetraenamide ligama lekhemikhali ye-anandamide (igama le-IUPAC) kwaye inokusetyenziswa kuphela kuncwadi lwenzululwazi.Nangona kunjalo, i-94421-68-8 yi-ID yayo ekhethekileyo yeekhemikhali (iNombolo yeRegistry yeCAS).Ekubeni i-AEA lixesha elifutshane kakhulu le-anandamide, sinokusebenzisa i-AEA rhoqo ukubhekisela kwi-anandamide kwezi zibhalo zilandelayo kunye nemifanekiso.
Igama lemveliso:UbuninziAnandamide powder
Izithethantonye:Arachidonoyl Ethanolamide, AEA powder, arachidonoylethanolamide, (5Z,8Z,11Z,14Z)-N-(2-hydroxyethyl)icosa-5,8,11,14-tetraenamide,N-arachidonoylethanolamine
Inombolo yeCAS: 94421-68-8
Inxalenye yesityalo esetyenzisiweyo: Igqabi
Isithako:Apigenin
Isivavanyi: ioyile yeAEA: 90%
Umgubo we-AEA: 50%
Umbala:Umgubo omthubi
ioli etyheli-mdaka
Ukupakisha: kwi-25kgs fiber drums
Ugcino: Gcina isikhongozeli singavulwanga kwindawo epholileyo neyomileyo, Zigcine kude nokukhanya okuqinileyo
Ubomi beShelf: iinyanga ezingama-24 ukusuka kumhla wokuvelisa
Ngokutsho kweWikipedia, i-anandamide yinto engapheliyo ye-cannabinoid neurotransmitter engqondweni, okuthetha ukuba ingqondo yomntu iyakwazi ukuvelisa i-anandamide ngaphandle kokuthatha ukutya okune-AEA.Ubuchopho beentlobo zezilwanyana ezanyisayo kunye nekoko ekrwada ziqinisekisiwe ukuba zinenani elithile le-anandamide.
Imithombo yokutya ye-anandamide
Akukho mithombo yendalo ethe ngqo ye-anandamide, kwaye itshokolethi kunye neetruffles ziphezu kwazo.I-Truffle ibiza kakhulu ukufumana i-anandamide, kwaye itshokholethi ibonakala ingowona mthombo uthembekileyo kwizixa ezikhulu ezizinzileyo ekutyeni.
Anandamidekunye neetshokolethi
Iimbotyi zeCacao, umthombo weetshokholethi, zikwangumthombo otyebileyo we-anandamide.Kukho ngaphezu kwe-300 yezakhi zekhemikhali kwitshokolethi.I-caffeine, i-theobromine, kunye ne-phenylethylamine zizithako ezaziwayo eziphakamisa umoya wethu.I-theobromine eneneni inceda ukuvuselela ingqondo ukuba ikhuphe i-anandamide ngakumbi ukusenza sonwabe ngakumbi.
Kutheni le nto i-anandamide ithandwa kangaka kwiminyaka yakutshanje?
Ngaphambi kokuba siphendule lo mbuzo, kufuneka sikhankanye i-cannabis, i-THC kunye ne-CBD (Cannabidiol) kuqala.
I-Cannabis, ekwabizwa ngokuba yintsangu, sisityalo esineentyatyambo, kwaye abantu bayisebenzisa njengechiza lepati okanye bayitshaye ukwenza "ukuphakama" okanye "ukuxutywa ngamatye".
Isithako esisebenzayo kwi-cannabis esenza ukuba ube phezulu yi-THC, enegama elipheleleyo njenge-delta 9-Tetrahydrocannabinol.Xa abantu betshaya i-marijuana, i-tetrahydrocannabinol kwi-cannabis ivuselela i-cannabis receptor, yenza abantu bazive benolonwabo kunye nempilo yengqondo.
I-Cannabis ayikho mthethweni kumazwe amaninzi kuba abantu abaninzi baya kuba likhoboka layo.
Nangona kunjalo, iUruguay lilizwe lokuqala ukwenza ngokusemthethweni i-cannabis ngonyaka ka-2013.
Nge-17 kaOkthobha ka-2018, urhulumente waseCanada wabhengeza ukuba i-cannabis isemthethweni kulo lonke elaseCanada.
E-United States, i-10 ithi kunye neSithili sase-Columbia zikuvumele ngokusemthethweni ukusetyenziswa kwe-cannabis ngokuzonwabisa nangona ihlala ingekho mthethweni.
Anandamide vs THC
I-Cannabis ngumthombo wesityalo se-THC.
I-Anandamide yinguqulelo yomntu ye-THC.
Isazinzulu sifumene i-AEA kwi-1992 kunye ne-THC kwi-1964.
I-Anandamide ikhupha iikhemikhali eziphucula umoya kwingqondo, kwaye indlela yayo yebhayoloji iyafana naleyo ye-tetrahydrocannabinol kwi-cannabis.
Ewe, bajolise kwi-receptor ye-cannabis efanayo, kwaye siza kuthetha malunga nendlela ye-AEA kungekudala.
Nangona kunjalo, amandla e-THC yomelele ngakumbi kune-AEA.Imvakalelo yokuthatha i-AEA ayimnandi kangako kuneyokutshaya i-cannabis kuba i-anandamide yenza imetabolis ngokukhawuleza emzimbeni, mhlawumbi kwimizuzu engama-30.
Kuba i-cannabis yalelwe kumazwe amaninzi, izongezo, ukutya, iziselo okanye izithambiso ezine-THC azikho mthethweni.Ngale ndlela, i-anandamide likamva.
Anandamide vs CBD
Isityalo sentsangu sineekhompawundi ze-400 +, kwaye ngaphezu kwe-60 eyahlukeneyo ye-cannabinoids ibophelela kwi-receptors emzimbeni wethu.
I-CBD yindlela emfutshane ye-cannabidiol kwaye yenye yezo cannabinoids ze-60.I-CBD yi-phytocannabinoid kwi-cannabis.Ngaphezulu kwe-40% ye-cannabis extract yi-CBD.
Iingcali zenzululwazi kunye noogqirha bafumanisa ukuba i-CBD iyakwazi ukuphucula inqanaba le-anandamide kwii-synapses zobuchopho njenge-anandamide reuptake kunye ne-breakdown inhibitor.I-fatty acid amide hydrolase, eyaziwa ngokuba yi-FAAH ngokufutshane, yi-enzyme ephula i-AEA.Yileyo ndlela i-CBD inqanda ngayo i-FAAH kwaye iphucula i-AEA ngokwemvelo.
I-CBD inokwenza okungakumbi kunoko.I-CBD inokuba luncedo kuyo yonke i-Endocannabinoid System
Indlela yokwenza i-anandamide
Isebenza njani i-anandamide?Inzima ngokwenene.Unokufuna kuqala ukwazi malunga nenkqubo ye-endocannabinoid, i-CB1 receptor, kunye ne-CB2 receptor.
CB1
I-THC inobudlelwane obuphezulu be-CB1 receptor, idibanisa kakhulu kwi-receptor.
Ukongeza, i-anandamide ichaphazela imvakalelo "ephezulu" ngokuchaphazela i-CB1 receptor, isebenze inkqubo yomvuzo wengqondo kunye nokuvelisa imichiza yolonwabo efana ne-dopamine Hormone.
CB2
Unokufumana ii-receptors ze-CB2 kwiiseli zomzimba wakho wonke.I-receptor ye-CB2 ijongene neempendulo ze-neuroprotective kunye nokulwa nokuvuvukala.Izazinzulu zikholelwa ukuba i-CB2 receptor inenzuzo ekuthomalaliseni iintlungu.
I-CB1 i-receptors igxininiswe ngokuyinhloko kwingqondo kunye nenkqubo ye-CNS, ngelixa i-CB2 i-receptors ifumaneka ikakhulu kwi-immune system.
Inkqubo ye-Endocannabinoid (ECS)
Ngaphambi kokuxoxa ngemisebenzi ye-endocannabinoid system (ECS), kubalulekile ukuqonda amacandelo ayo.I-ECS iqulethwe ngama-receptors e-cannabinoid, i-ligands engapheliyo (i-amolekyu ezibophayo) kulawo ma-receptors, kunye nama-enzymes adibanisa kunye nokunciphisa i-ligands.
| ECS yakudala | I-ECS eyandisiweyo | |
| i-cannabinoid receptors | CB1, CB2 | PPAR, GPR, TRPV, FLAT, FABP |
| i-endogenous ligands | AEA, 2-AG | OEA,PEA,2-AGE,NADA,VA,EPEA,SEA,OA,DHEA |
| Ii-Enzymes ezonakalisa i-ligands | FAAH, MAGL | ABHD6,COX-2,ABHD12 |
| Ii-enzymes ezidibanisa iiligands | I-DAGL, i-NAT, i-NAPE-PLD | I-SHIP1, PTPN22,PLC,GDEI,ABHD4 |
isangqa sangaphakathi (ingwevu ekhanyayo) imele inkqubo ye-endocannabinoid 'yeklasiki'.Isangqa sangaphandle (igrey emnyama) ibandakanya amacandelo enkqubo ye-endocannabinoid eyandisiweyo.Njengoko unokubona, i-PEA, i-SEA, kunye ne-OEA nazo zibandakanyiwe kwinkqubo ye-endocannabinoid.
I-ECs ine-system central nervous system (CNS) imvelaphi kwaye iquka i-anandamide (AEA), i-2-arachidonoylglycerol (2-AG), i-noladin ether, i-virodhamine kunye ne-N-arachidonylodopamine (NADA).Kwaye i-anandamide yeyokuqala kwaye yeyona ligand ibalulekileyo kwinkqubo ye-endocannabinoid.
I-Anandamide kunye ne-2-AG
Njengoko kukhankanyiwe ngasentla, i-anandamide (AEA) kunye ne-2-arachidonoylglycerol (i-2-AG) ziyi-ligand eziphambili kwiinkqubo ze-ECS.I-ECS inceda ukulawula imisebenzi efana nokulala, amajoni omzimba, kunye nokuguqulwa kweentlungu.
Izazinzulu zafumanisa i-Anandamide ngonyaka we-1992 kunye ne-2-AG 3 iminyaka kamva.I-AEA kunye ne-2-AG zinesakhiwo esifanayo se-molekyuli kwaye ngaloo ndlela iimpawu zomzimba kunye neekhemikhali ezifanayo.
I-Anandamide ijolise ikakhulu kwi-receptor CB1 kwingqondo, ngelixa i-2-AG ijolise kuzo zombini i-CB1 kunye ne-CB2 receptors (kwi-immune system).
Zombini i-Anandamide kunye ne-2-AG zenziwe nge-arachidonic acid, i-Omega-6 fatty acid, eneendlela ezahlukeneyo kunye ne-synthesizing enzymes.I-enzyme yokunciphisa i-FAAH (i-Fatty Acid Amide Hydrolase) ye-AEA kunye ne-2-AG nge-enzyme ye-MAGL (i-Monoacylglycerol Lipase).
IiNzuzo zeAnandamide
Ubungqina besayensi bubonisa ukuba i-anandamide inokuba yinto efanelekileyo yokuchasana nokuxhalaba, impilo yengqondo, ukulungiswa kwememori, ukulawula ukutya, ukunciphisa iintlungu, i-neuroprotection, kunye nokunye.
Anandamide kunye nexhala
Abantu babiza uAnandamide "imolekyuli yolonwabo" kuba i-AEA iyakwazi ukwenza uzive wonwabile.
Ubungqina obuguqukayo bucebisa ukuba inkqubo ye-endocannabinoid iyinxalenye ebalulekileyo ye-neuronal substrates ebandakanyekayo kwiinkqubo zokuvuza kwengqondo kunye neempendulo zeemvakalelo kuxinzelelo.
I-Pharmacological blockade ye-enzyme fatty acid amide hydrolase (FAAH), ejongene nokuthotywa kwe-anandamide ye-intracellular, ivelisa iziphumo ezinjenge-anxiolytic kwiigundane ngaphandle kokubangela uluhlu olubanzi lweempendulo zokuziphatha eziqhelekileyo ze-agonists ze-cannabinoid ezisebenza ngokuthe ngqo.
Ezi ziphumo zibonisa ukuba i-anandamide inegalelo ekulawuleni iimvakalelo kunye nokuxhalaba kwaye i-FAAH inokuba yinto ekujoliswe kuyo kwiklasi yenoveli yeziyobisi ze-anxiolytic.
Ngolwazi oluthe vetshe ngeziphumo ze-anandamide kwixhala, nceda ufunde olu ncwadi lungezantsi:
- I-endogenous cannabinoid anandamide ineempembelelo kwinkuthazo kunye nokuxhalaba okutyhilwa yi-fatty acid amide hydrolase (FAAH) inhibition.
- I-Anandamide hydrolysis: into ekujoliswe kuyo entsha yamachiza okulwa nokuxhalaba?
- Ukunciphisa ukuziphatha okufana nokuxhalaba okubangelwa yi-genetic kunye ne-pharmacological inhibition ye-endocannabinoid-degrading enzyme fatty acid amide hydrolase (FAAH) idibene ne-CB1 receptors.
Anandamide kunye nokuphelisa iintlungu
ome ubungqina besayensi bubonisa ukuba inhibition ye-FAAH (i-enzyme ehlisa i-anandamide kwingqondo) yanciphisa kakhulu iimpendulo ze-nociceptive kwiimodeli ezininzi zentlungu.
I-FAAH inhibitors iphucula kakhulu amanqanaba e-anandamide kwingqondo kwaye ngokuyintloko yenza i-CB1i-receptor-mediated antinociception, ecebisa ukuba i-anandamide engapheliyo, xa ikhuselwe ekuthotyweni, inokuvelisa i-antinociception nge-CB.1abamkeli.
I-Palmitoylethanolamide (PEA) sisithako esingapheliyo esonyusa umsebenzi we-anandamide.Umzimba womntu ngokwendalo uvelisa i-PEA ukulwa nokudumba kunye neentlungu.Ngaphezulu kwezigulane ze-800,000 ziye zaba iipilisi ze-PEA kunye nezongezo zokutya zokunyanga iintlungu emhlabeni.
Ukuze ufunde ngakumbi malunga ne-PEA, nceda undwendwele yethuiphepha lePEA.
I-Anandamide kunye nembaleki iphezulu
Masiqale sijonge inkcazo yokuba yintoni imbaleki ephezulu: imvakalelo yokonwaba kunye nokuncipha kokukhathazeka kunye nokuncipha kwesakhono sokuva iintlungu.Emva komthambo omde we-aerobic, uya kuba namava amnandi ngolo hlobo ngexesha lokubaleka ixesha elide.
Kumashumi eminyaka adlulileyo, abaphandi bacinga ukuba i-endorphin kuphela kwento enoxanduva lwabagijimi abaphakamileyo kuba amanqanaba okwanda kwe-β-endorphins afumaneka lula egazini.Njengoko usenokuba uyazi, i-endorphin inamandla okuphucula imo yethu kunye nokwenza imvakalelo yolonwabo.
Nangona kunjalo, izazinzulu ngoku zikholelwa ukuba yinkqubo ye-endocannabinoid (ECS) kunye ne-anandamide ebangela ukuba imbaleki ibe phezulu.I-Anandamide iyakwazi ukuwela umqobo wegazi-ingqondo kwaye inike iziphumo ezisembindini ze-peripheral opioids.Kodwa i-endorphin ayikwazi.
Ukuba ufuna ukufunda malunga novavanyo malunga nokuphezulu kwembaleki, funda olu ncwadi:Ukuphakama kwembaleki kuxhomekeke kwi-cannabinoid receptors kwiimpuku
Iingcali zezondlo zifumanisa ukuba i-anandamide inokuba ngumlawuli olungileyo wokutya.I-Anandamide inokuvuselela ukulamba kwakho kunye nomnqweno wokutya ngakumbi.Ukuba usendleleni yokunciphisa umzimba, cinga ngenyameko ngaphambi kokuba uthathe i-AEA.
Izongezo eziqulethe i-anandamide
Ngaba ujonge izongezo ze-anandamide okanye iipilisi ze-anandamide?
Ngelishwa, akukho nanye okwangoku.I-Anandamide sisithako senoveli kangangokuba akukho zimpawu zokuncedisa ukutya ezikhe zazama kwiifomula zazo zangoku.
Unokufumana inkampani ebizwa ngokuba yi-Sun Potion ithengisa i-anandamide powder kwi-Amazon.Nangona kunjalo, asiyonyaniso leyo.Yipowder ekrwada yecocoa kuphela, kodwa ayifani ne-anandamide extract.Kwaye umxholo osebenzayo kwifomu yomgubo uphantsi kakhulu, kwaye awukwazi ukufumana ukusebenza kwe-AEA.
Ewe kunjalo, unokufumanisa ukuba abanye ababoneleli bathengisa imigangatho yereferensi ye-anandamide okanye ii-reagents.Into embi kukuba bathengisa kuphela kwi-5mg, i-25mg, kwaye kuphela uphando kuphela.Akukho lwazi luninzi lwe-oyile ye-AEA ekhoyo konke konke.
Iindaba ezimnandi zezokuba abavelisi bezongezelelo e-United States nakumazwe aseYurophu anje ngeJamani, eFransi, eNetherland, e-UK, eSpain, eItali, njl. njl .
Iimpawu zeAnandamide
Ioli ye-anandamide eninzi kunye ne-anandamide powder zombini ziyafumaneka kwi-Cima Science.
Ioli yeAnandamide: 70%, 90%
Anandamide powder: 50%
