Igama lemveliso:Stearoyl Vanillylamide(SVA）
Elinye Igama:C18-VA, N-Vanillyloctadecanamide,Capsaicin AnalogCAS Number:58493-50-8
Umthombo wezityalo:Piper Longum Linn
Uvavanyo: 98%
Isampulu yasimahla :Iyafumaneka
Imbonakalo:mhlophe ukuya kumgubo omhlophe
Iinzuzo:Anti-umhlaza, anti-ukuguga, senolytic
Ubomi beShelf: iminyaka emi-2
I-Stearoyl vanillylamide yenye yezona zifaniso zidumileyo ze-capsaicin kwaye yindalo ye-capsaicin analog efumaneka kwiintlobo zepepile ebomvu.I-Capsaicin yimbangela yobushushu / ukutshisa okubangelwa yipepile.Ngokungafani nezinye iintlobo ze-capsaicin kwinqanaba elifanayo, i-Stearoyl vanillylamide iyingqayizivele kuba i-non-steroidal, ithetha ukuba ayivelisi "i-spicy" okanye imiphumo ecasulayo ye-capsaicin.
Ngokuqhelekileyo, njengezinye i-capsaicin analogs, le khompawundi isebenza ngokunyusa ukukhululwa kwe-epinephrine kunye ne-norepinephrine.La mahomoni ayafuneka ukuze avule iintshukumo ezahlukeneyo zomzimba ezinovelwano ezifana nemetabolism.Ke ngoko, i-stearoyl vanillylamide ekugqibeleni inegalelo ekutshisweni kwamafutha amdaka kwi-adipose tissue okanye kwi-subcutaneous tissue.
Ziziphi iingenelo zokusebenzisa iStearoyl Vanillylamide?Ukufakwa kwe-stearic acid amide kuneenzuzo ezininzi ekulungiseleleni izongezo zezempilo.Njengoko uphononongo oluninzi lusaqhuba, izazinzulu zijonge phambili ekufumaneni ngakumbi izibonelelo zokusebenzisa le khompawundi.Ezi zilandelayo zezinye zezibonelelo ezaziwa ngokusebenzisa iStearoyl vanillylamide:
Iqhekeza ngokufanelekileyo amanqatha esisu
I-Stearoyl vanillylamide isebenza njenge-capsaicin engacaphukiyo ekwazi ukuvuselela izicubu ze-adipose ezimdaka okanye amafutha amdaka (amafutha afumaneka ikakhulu kwi-mitochondria kwaye avelise ubushushu emzimbeni).Amafutha afumaneka kuwo onke amalungu omzimba, kubandakanywa iingalo, amathanga, isisu kunye nezihlunu zegluteal.Nangona abaninzi abantu banokukhawuleza balahle amanqatha kwezinye iindawo, ukutshisa amanqatha esiswini kuthathwa njengomthwalo wangempela.Uphononongo lubonise ukuba ukuthatha i-Stearoyl vanillylamide kunokunceda ukuphula amafutha abekwe ngokukodwa kwisisu.Oku kufezekiswa ngokuvula i-TRPV1, i-enzyme evimbela ukuveliswa kwamafutha esiswini kunye nokwakhiwa kwamafutha.Kanye kunye ne-capsaicin, i-Stearoyl vanillylamide ithathwa njengenye yee-arhente ezijolise kwaye zisebenze i-TRPV1 (i-receptor ye-transient potential vanilloid) efumaneka kwi-membrane ye-plasma (ngaphandle kwe-ligands engapheliyo, abalamli abavuthayo kunye ne-non-elective stimuli).Inoxanduva lokufaka ikhowudi kwiprotheni ye-membrane edibeneyo njengejelo le-ion.Xa i-TRPV1 isetyenziswe ngokukodwa kwiifayili ze-sensory kunye neeseli ezingenayo i-neuronal, iya kubangela ukunyuka kwe-calcium kunye ne-sodium, efunekayo kwi-membrane depolarization (inguqu ye-polarity; ukusuka kwi-negative ukuya kwi-positive, ekhokelela kwimiphumo emihle) unxibelelwano.
Iqhekeza ngokufanelekileyo amanqatha esisu
I-Stearoyl vanillylamide isebenza njenge-capsaicin engacaphukiyo ekwazi ukuvuselela izicubu ze-adipose ezimdaka okanye amafutha amdaka (amafutha afumaneka ikakhulu kwi-mitochondria kwaye avelise ubushushu emzimbeni).Amafutha afumaneka kuwo onke amalungu omzimba, kubandakanywa iingalo, amathanga, isisu kunye nezihlunu zegluteal.Nangona abaninzi abantu banokukhawuleza balahle amanqatha kwezinye iindawo, ukutshisa amanqatha esiswini kuthathwa njengomthwalo wangempela.Uphononongo lubonise ukuba ukuthatha i-Stearoyl vanillylamide kunokunceda ukuphula amafutha abekwe ngokukodwa kwisisu.Oku kufezekiswa ngokuvula i-TRPV1, i-enzyme evimbela ukuveliswa kwamafutha esiswini kunye nokwakhiwa kwamafutha.Kanye kunye ne-capsaicin, i-Stearoyl vanillylamide ithathwa njengenye yee-arhente ezijolise kwaye zisebenze i-TRPV1 (i-receptor ye-transient potential vanilloid) efumaneka kwi-membrane ye-plasma (ngaphandle kwe-ligands engapheliyo, abalamli abavuthayo kunye ne-non-elective stimuli).Inoxanduva lokufaka ikhowudi kwiprotheni ye-membrane edibeneyo njengejelo le-ion.Xa i-TRPV1 isetyenziswe ngokukodwa kwiifayili ze-sensory kunye neeseli ezingenayo i-neuronal, iya kubangela ukunyuka kwe-calcium kunye ne-sodium, efunekayo kwi-membrane depolarization (inguqu ye-polarity; ukusuka kwi-negative ukuya kwi-positive, ekhokelela kwimiphumo emihle) unxibelelwano.
