Umgubo weWogonin omninzi

Isininzi sePowder yeWogonin eFakelweyo Umfanekiso
  • Umgubo weWogonin omninzi

Inkcazelo emfutshane:

I-Wogonin yi-O-methylated flavonoid, i-flavonoid compound efumaneka kwi-Scutellaria baicalensis.I-Scutellaria baicalensis, ekwabizwa ngokuba yi-Huang Qin, i-Baikal skullcap, i-Chinese skullcap, isityalo se-scutellaria (Labiaceae), iingcambu zayo ezomileyo zibhalwe kwi-Chinese pharmacopeia, i-Skullcap. ibisetyenziswa kakhulu yiTshayina, kunye nabamelwane bayo kangangamawaka eminyaka.


  • FOB ixabiso:US $ 0.5 - 2000 / KG
  • Min.Ubungakanani boMyalelo:1KG
  • Ukubonelela ngezakhono:I-10000 KG / ngenyanga
  • Izibuko:SHANGHAI/BEIJING
  • Immimiselo yokuhlawula:L/C,D/A,D/P,T/T
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    • Khuphela njengePDF

    Iinkcukacha zeMveliso

    Iithegi zeMveliso

    Igama lemveliso:Wogonin Bulk Powder

    Umthombo wezityalo:Scutellaria baikalensis

    Inombolo yeCAS:632-85-9

    Elinye Igama:Vogoni, wagonin, Wogonin hydrate, Vogonin Norwogonin 8-methyl ether

    Iinkcukacha:≥98% HPLC

    Umbala: Umgubo omthubi onevumba elibonakalayo kunye nencasa

    Isimo se-GMO:GMO Mahala

    Ukupakisha: kwi-25kgs fiber drums

    Ugcino: Gcina isikhongozeli singavulwanga kwindawo epholileyo neyomileyo, Zigcine kude nokukhanya okuqinileyo

    Ubomi beShelf: iinyanga ezingama-24 ukusuka kumhla wokuvelisa

    I-Scutellaria baikalensis iqulethe iindidi zeekhemikhali, ezifana ne-flavonoids eyahlukeneyo, i-diterpenoids, i-polyphenols, i-amino acids, ioli eguquguqukayo, i-sterol, i-benzoic acid, njalo njalo.Iingcambu ezomileyo zineentlobo ezingaphezu kwe-110 ze-flavonoids ezifana ne-baicalin, i-baicalein, i-wogonoside, kunye ne-wogonin, eyona nto isebenzayo ye-Scutellaria baikalensis.Isicatshulwa esisemgangathweni esifana ne-80% -90% HPLC Baicalin, 90% -98% HPLC Baicalein, 90% -95% HPLC Wogonoside, kunye ne-5% -98% HPLC Wogonin

     

    Kwi-Vitro Activity: I-Wogonin inqanda i-PMA-induced i-COX-2 i-gene expression ngokuthintela i-c-Jun expression kunye nokusebenza kwe-AP-1 kwiiseli ze-A549[1].I-Wogonin yi-inhibitor ye-cyclin-dependent kinase 9 (CDK9) kunye ne-block phosphorylation ye-carboxy-terminal domain ye-RNA polymerase II kwi-Ser.Ke ngoko, inciphisa i-RNA synthesis kwaye emva koko kuthotywe ngokukhawuleza kwe-anti-apoptotic protein ye-myeloid cell leukemia 1 (Mcl-1) ekhokelela ekungenisweni kwe-apoptosis kwiiseli zomhlaza.I-Wogonin ibophelela ngokuthe ngqo kwi-CDK9, mhlawumbi kwi-ATP-ibophelela i-pocketa kwaye ayivimbeli i-CDK2, i-CDK4 kunye ne-CDK6 kwiidosi ezithintela umsebenzi we-CDK9.I-Wogonin ngokukhethekileyo inqanda i-CDK9 kwi-malignant xa kuthelekiswa ne-lymphocytes eqhelekileyo.I-Wogonin ikwasisithinteli-oksijini esinamandla esikwaziyo ukutshabalalisa i-?O2?[2].I-Wogonin inqanda kakhulu ukuhanjiswa kwe-NFATc1 ukusuka kwi-cytoplasm ukuya kwi-nucleus kunye nomsebenzi wayo wokwenza i-transcriptional activation.Ikwanqanda ngokuphawulekayo umahluko we-osteoclast kwaye yehlise ushicilelo lwe-osteoclast?enxulumene ne-immunoglobulin?njenge-receptor, i-tartrate?resistant acid phosphatase kunye ne-calcitonin receptor[4].I-Wogonin Ithintela uMsebenzi we-N-acetyltransferase

    KuMsebenzi weVivo: iWogonin icinezela ukukhula komhlaza womntu kwi-vivo.Kwiidosi ezibulalayo kwiiseli zethumba, i-wogonin ayibonisi tyhefu okanye incinci kwiiseli eziqhelekileyo kwaye ayinayo netyhefu ecacileyo kwizilwanyana[2].I-Wogonin inokubangela i-apoptosis kwi-murine sarcoma S180 ngaloo ndlela inqanda ukukhula kwethumba kwi-vitro nakwi-vivo[3].Inaliti ye-intraperitoneal ye-200 mg/kg ye-Wogonin inokuthintela ngokupheleleyo i-leukemia kunye neeseli ze-CEM

     

    Imifuniselo yeeseli:

    Iiseli ze-A549 ziyinkcubeko kwi-plate ye-24-well (1.2 × 105 iiseli / kakuhle) 1 usuku ngaphambi kokuba unyango lwe-wogonin.I-DMSO okanye i-wogonin yongezwa kwiiseli ze-A549 1 h ngaphambi kokuvuselela i-PMA, kwaye iiseli zifakwe enye i-6 h.Iiseli ziqokelelwa ngonyango lwe-trypsin kwaye amanani eeseli abalwa ngokusebenzisa i-hemocytometer kunye ne-trypan blue exclusion method.

     

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