Umgubo weLupeol 98%

I-Lupeol Powder 98% Umfanekiso obonakalayo
  • Umgubo weLupeol 98%

Inkcazelo emfutshane:

I-Lupeol powder yi-triterpene entsha yokutya.I-Lupeol yinto entsha ye-androgen receptor blocker.

I-Lupeol (i-Clerodol; i-Monogynol B; i-Fagarasterol) i-pentacyclic triterpene esebenzayo kunye ne-antioxidant, i-antitumor kunye ne-anti-inflammatory activities.I-Lupeol yi-androgen receptor inhibitor enamandla kwaye ingasetyenziselwa uphando lomhlaza, ngakumbi kwi-prostate cancer kunye ne-androgen-dependent phenotype (ADPC) kunye ne-castration-resistant phenotype (CRPC).


  • FOB ixabiso:US $ 0.5 - 2000 / KG
  • Min.Ubungakanani boMyalelo:1KG
  • Ukubonelela ngezakhono:I-10000 KG / ngenyanga
  • Izibuko:SHANGHAI/BEIJING
  • Immimiselo yokuhlawula:L/C,D/A,D/P,T/T
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    Iinkcukacha zeMveliso

    Iithegi zeMveliso

    Igama lemveliso:Umgubo weLupeol98%

    Umthombo weBhotani:Mango, Acacia visco, Abronia villosa, Dandelion ikofu.

    CASNo:545-47-1

    Umbala:Mhlophe ukuya kumhlopheumgubo onevumba elibonakalayo kunye nencasa

    Iinkcukacha:≥98% HPLC

    GMOIsimo:GMO Mahala

    Ukupakisha: kwi-25kgs fiber drums

    Ugcino: Gcina isikhongozeli singavulwanga kwindawo epholileyo neyomileyo, Zigcine kude nokukhanya okuqinileyo

    Ubomi beShelf: iinyanga ezingama-24 ukusuka kumhla wokuvelisa

    Umsebenzi webhayoloji:

    I-Lupeol (i-Clerodol; i-Monogynol B; i-Fagarasterol) i-pentacyclic triterpenoid esebenzayo, ine-anti-oxidant, i-anti-mutagenic, i-anti-tumor kunye ne-anti-inflammatory activity.I-Lupeol inamandlai-androgen receptor(AR) inhibitor kwaye ingasetyenziselwaumhlazauphando, ngakumbi i-prostateumhlazaye-phenotype exhomekeke kwi-androgen (ADPC) kunye ne-castration resistant phenotype (CRPC) [1].

     

    I-In vitro Uphando:

    I-Lupeol sisithinteli se-AR esinamandla esinokuphuhliswa njengechiza elinokubakho kunyango lwe-human prostate cancer (CaP).I-Lupeol (i-10-50 μM) unyango lwe-48 h lubangele ukuvinjelwa kokukhula okuxhomekeke kwi-dose yeeseli ze-phenotype (ADPC) ezixhomekeke kwi-androgen, ezizezi iiseli ze-LAPC4 kunye ne-LNCaP, kunye ne-IC50 ye-15.9 kunye ne-17.3 μM, ngokulandelanayo.I-Lupeol ikwathintele ukukhula kwe-22Rν_1 nge-IC50 ye-19.1 μM.Ukongezelela, i-Lupeol inqanda ukukhula kweeseli ze-C4-2b kunye ne-IC50 ye-25 μM.I-Lupeol inamandla okuthintela ukukhula kweeseli ze-CaP zombini i-ADPC kunye ne-CRPC phenotypes.Ii-Androgens zaziwa ngokuqhuba ukukhula kweeseli ze-CaP ngokwenza kusebenze i-AR[1]

     

    KuPhando lweVivo:

    I-Lupeol lichiza elisebenzayo elinamandla okuthintela i-tumorigenicity yeeseli ze-CaP kwi-vivo.Amanqanaba e-PSA ajikelezayo e-serum (efihliweyo ngamaseli e-tumor afakwe) alinganiswe ekupheleni kophando ngosuku lwe-56. Ngosuku lwe-56 emva kokufakelwa, amanqanaba e-PSA ukusuka kwi-11.95-12.79 ng / mL abonwa kwizilwanyana zokulawula kunye ne-LNCaP tumors kunye C4-2b amathumba, ngokulandelanayo.Nangona kunjalo, oogxa abaphathwa nge-Lupeol babonise amanqanaba ancitshisiweyo e-serum e-PSA ukusuka kwi-4.25-7.09 ng / mL.Izihlunu zethumba kwizilwanyana eziphathwe ngeLupeol zibonise amanqanaba ancitshisiweyo e-serum ePSA xa kuthelekiswa nolawulo[1]

     

     

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