Igama leMveliso: Celastrol bulk powder
Umthombo weBhotani:The God Vine(Tripterygium wilfordii hook.f)
CASNo:34157-83-0
Umbala: Ubomvu obomvu wekristale engumgubo kunye nevumba elibonakalayo kunye nencasa
Iinkcukacha:≥98% HPLC
GMOIsimo:GMO Mahala
Ukupakisha: kwi-25kgs fiber drums
Ugcino: Gcina isikhongozeli singavulwanga kwindawo epholileyo neyomileyo, Zigcine kude nokukhanya okuqinileyo
Ubomi beShelf: iinyanga ezingama-24 ukusuka kumhla wokuvelisa
Umgubo weCelastrolsisithako esisebenzayo kwiTripterygii Radix, eyingcambu eyomileyo kunye nerhizome yoMdiliya kaThixo.Kukho iintlobo ezine xa zizonke, ezizeziI-Tripterygium wilfordii Hook.f, i-Tripterygium hypoglaucum Hutch, i-Tripterygium rekelii Sprague et Takeda, kunye ne-Tripterygium forresti Dicls.
I-Diterpenoids: i-triptolide (cas no.38748-32-2), i-Tripdiolide (cas no.38647-10-8), njl.
Triterpenoids: Celastrol (cas no.34157-83-0), Wilforlide A (cas no.84104-71-2), njl.
Alkaloids:Wilforgine(cas no.37239-47-7), Wolverine (cas no.11088-09-8), wilforidine, njl.
I-Tripterygium yi-pentazine triterpene efumaneka ngokwemvelo kwi-Tripterygium wilfordii.Iyasebenza ekunyangeni isifo samathambo.I-Triptolide inqanda i-proteasome kunye ne-nuclear factor Kb ekusebenzeni.
I-Celastrol (i-Tripterin) i-proteasome inhibitor ene-anti-inflammatory and antioxidant activities.Isebenza ngokufanelekileyo kwaye ngokukhethiweyo inqanda umsebenzi ofana ne-chymotrypsin we-20S proteasome kunye ne-IC50 ye-2.5 μM.
I-Tripterine yi-antioxidant enamandla kunye ne-anti-inflammatory agent.I-HSP90 inhibitor entsha (iphazamisa i-Hsp90 / Cdc37 complex), ineempembelelo ezichasene nomhlaza (i-anti-angiogenesis - inqanda i-vascular endothelial growth factor receptor expression);i-antioxidant (inqanda i-lipid peroxidation) kunye nomsebenzi wokuchasana nokuvuvukala (Ivimbela ukuveliswa kwe-iNOS kunye ne-cytokines evuthayo)
BiologicalAumsebenzi:
I-Celastrol (i-Tripterin) iphantsi-ilawula i-basal kunye ne-DNA-i-agent-eyenziwe i-FANCD2 monoubiquitination, elandelwa yi-protein degradation.Unyango lwe-Celastrol luphelisa i-IR-induced checkpoint ye-G2 kunye nokwandisa umonakalo we-DNA we-ICL owenziwe ngamachiza kunye nemiphumo yokuthintela kwiiseli zomhlaza wemiphunga ngokunciphisa i-FANCD2.I-Celastrol ineempembelelo ezibalulekileyo zokuthintela kunye ne-apoptosis-inducing kwiiseli ze-DU145 ezikhuliswe kwi-vitro ngendlela exhomekeke kwixesha kunye nedosi.Isiphumo somhlaza we-Celastrol esichasene ne-prostate siyinxalenye yokulawula inqanaba lokuthetha letshaneli ze-hERG kwiiseli ze-DU145, ecebisa ukuba i-Celastrol inokuba lichiza elinokubakho lokulwa nomhlaza wedlala lesidoda, kwaye indlela yayo inokuba kukuthintela amajelo e-hERG.I-Celastrol iphucula i-colitis yovavanyo kwi-IL-10-intsilelo yeempuku ngokuthintela i-PI3K/Akt/mTOR indlela yokubonisa kunye nokulawula i-autophagy.I-Celastrol inamandla okuthintela umsebenzi we-cytochrome P450 kwaye inokubangela ukusebenzisana kwemithi.I-Celastrol yenza i-apoptosis kwiiseli ze-TNBC, iphakamisa ukuba i-apoptosis inokungenelela ngokungasebenzi kakuhle kwe-mitochondrial kunye ne-PI3K/Akt yokubonisa indlela.I-Celastrol yenza i-apoptosis kunye ne-autophagy ngokusebenzisa i-ROS / JNK indlela yokubonisa.I-Celastrol inqanda ukufa kwe-dopaminergic neuron kwisifo sika-Parkinson ngokuvula i-apoptosis ye-mitochondrial.
Indima ye-Celastrol kwi-chemosensitization yomhlaza:
Unyango ngamachiza luhlala lulolona khetho lonyango lwezigulane ezinomhlaza.Nangona kunjalo, ichemotherapy kufuneka idityaniswe namanye amachiza ukunciphisa iziphumo ebezingalindelekanga kunye nokuthintela ukunganyangeki ngamachiza.Iimveliso zendalo ziya zisetyenziswa kakhulu njengonyango lwe-adjuvant zidityaniswe neerejimeni ezikhoyo zechemotherapy ukomeleza unyango olusebenzayo.Omnye umzekelo othembisayo weyeza lendalo elinjalo yikhompawundi ye-triterpene ebizwa ngokuba yi-celastrol, enokuba namandla amakhulu okusetyenziswa njenge-chemical sensitizer.Ichongiwe ekuqaleni kwi-Thunder God Vine, ilawula kakubi iimolekyuli ezininzi ze-oncogenic ezifana ne-NF-κB, i-topoisomerase II, i-Akt / mTOR, i-HSP90, i-STAT3, kunye ne-Notch-1.Oku kunokukhokelela ekuphenduleni okuchasayo, ukuvimbela ukukhula kwe-tumor kunye nokuphila, kunye nokuphelisa i-angiogenesis.Esi sahluko sishwankathela ngokufutshane indima enokwenzeka ye-celastrol njenge-chemosensitizer kunye neendlela ezisisiseko zemolekyuli elamla iziphumo zayo ezixeliweyo ze-chemosensitizing kwiintlobo zomhlaza ezahlukeneyo.
