Apigenin 98%

Apigenin, njenge-bioflavonoid eyaziwayo, ibonakaliswe ukuba ibonise imisebenzi eyahlukeneyo yezinto eziphilayo, kuquka i-antioxidant, i-anti-inflammatory, i-antitumor, i-ant-genotoxic, i-anti-allergic, i-neuroprotective, i-cardioprotective, kunye ne-antimicrobial.Nangona kunjalo, Enye yezona zinto zixhaphakileyo ze-apigenin icelery (Apium graveolens), isityalo somgxobhozo kusapho lwe Apiaceae esilinywe njengemifuno ukusukela kudala.I-Apigenin iyona sondlo ekhutshwe kakhulu kwi-celery, equkethe i-108 mg apigenin nge-kg.I-Apigenin yenye ye-flavonoids yokutya eqhelekileyo, efumaneka kakhulu kwiziqhamo ezininzi, imifuno, kunye nemifuno yokwelapha.Isebenza imisebenzi eyahlukeneyo yomzimba, efana ne-antioxidant, i-anti-inflammatory enamandla, imisebenzi ye-antiviral, i-antibacterial kunye nokunciphisa uxinzelelo lwegazi.

Igama lemveliso:Celery igqabi isicatshulwa Apigenin 98%

Igama lesiLatini: Apium graveolens L.

Inombolo yeCAS: 520-36-5

Inxalenye yesityalo esetyenzisiweyo: Igqabi

Isithako:Apigenin

Isivavanyi:Apigenin 98.0% yi-HPLC

Umbala:Omdaka ukuya kumgubo omthubi kunye nevumba elibonakalayo kunye nencasa

Isimo se-GMO:GMO Mahala

Ukupakisha: kwi-25kgs fiber drums

Ugcino: Gcina isikhongozeli singavulwanga kwindawo epholileyo neyomileyo, Zigcine kude nokukhanya okuqinileyo

Ubomi beShelf: iinyanga ezingama-24 ukusuka kumhla wokuvelisa

Impembelelo ye-Anti-tumor

I-Apigenin idlala indima ebalulekileyo ekuthinteleni umhlaza ngokubangela i-apoptosis kwiiseli ezahlukeneyo.

Umhlaza wesibeleko:

Olunye uphando lufunyenwe ukuba i-apigenin inokuthintela ukukhula, ukwanda, kunye nokudluliselwa kwe-ca-ov3 (iseli yomhlaza we-ovarian yomntu);yenza i-apoptosis ye-ca-ov3 ngokugcina i-stasis yeeseli zomhlaza kwisigaba se-G2 / M.Isiphumo sinxulumene nexesha kunye nethamo.

Umhlaza wePancreatic:

I-Apigenin inokuthintela ukwanda kweeseli zomhlaza we-pancreatic.I-Apigenin ilambisa ithumba ngokunciphisa umthombo weglucose, ekukutya okuhlala kukho iiseli zomhlaza.Ngaphandle koko, i-Apigenin inokuphucula ukusebenza kwechemotherapy drug- gemcitabine.

I-Chemo-sensitization

Kwafunyaniswa ukuba i-apigenin kumxholo ophantsi inesiphumo esisezantsi se-cytotoxic kwaye ayikwazanga ukwenza iiseli ze-acute myeloid leukemia (hl-60) kwi-apoptosis ngempumelelo.Nangona kunjalo, i-apigenin inokuphucula i-inhibitory effect ye-cisplatin (DDP) kwi-hl-60 yokwanda kweeseli ngelixa idibanisa kunye neentlobo ezahlukeneyo ze-DDP.Ngoko i-Apigenin inokuba ne-chemotherapy-sensitization effect kwi-hl-60;Uxinzelelo oluphantsi lwe-apigenin lunokunciphisa ukuchaswa kweeseli ze-hl-60 kwi-chemotherapy-induced apoptosis, enokuthi ihambelane nokulawulwa kwe-NF-κB kunye ne-BCL-2.(I-NF-KB luhlobo lweprotheyini eyinkimbinkimbi elawula ukubhalwa kwe-DNA, ukuveliswa kwe-cytokines kunye nokusinda kweeseli; I-BCL-2 ifakwe kwi-encoded emzimbeni nge-BCL2 gene, lilungu lokuqala le-BCL-2 yentsapho yeeprotheni ezilawulayo. inokulawula ukufa kweeseli)

Ukukhuselwa kwesibindi

I-Apigenin inokunciphisa ukulimala kwesibindi okubangelwa yi-ischemia-reperfusion ngokusebenzisa i-lipid peroxidation echasayo kunye nokukhupha i-radicals yamahhala.

I-Apigenin inokunciphisa ukulimala kwesibindi okubangelwa uxinzelelo lwe-oxidative ngenxa yemisebenzi yayo enamandla ye-antioxidant kunye ne-anti-inflammatory.

Uvavanyo lwe-Pharmacological luye lwabonisa ukuba i-apigenin inempembelelo ebonakalayo yokukhusela kwi-alcohol-induced isibindi / i-hepatocyte, kwaye indlela yayo ephambili ihambelana nokuvinjelwa kwe-CYP2E1 ibonakaliso kwisibindi / i-hepatocyte.

Thintela i-osteoporosis

I-Apigenin inqanda i-osteoblastogenesis, i-osteoclastogenesis, kwaye ikhusela ukulahleka kwethambo.

I-Apigenin ikhusela izicubu zethambo ngokunciphisa ukulahleka kwamathambo emzimbeni.

Ezinye izifundo ezinxulumene ne-MC3T3-E1, i-osteoblast precursor cell line ephuma kwi-Mus musculus (mouse) calvaria, yafumanisa ukuba i-apigenin inokuthintela i-TNF-α, i-IFN-γ, kwaye emva koko yenza ukukhutshwa kwee-cytokines ezininzi ezikhuthaza ukubunjwa kwe-osteoclast.

I-Apigenin iphinde ivimbele ukuhlukana kweeseli ze-3T3-L1 ze-adipose precursor kwi-adipocytes ngamandla, ngoko ke inhibition inhibition i-different inhibition i-adipocyte differentiation-induced IL-6, MCP-1, imveliso ye-lectin.

I-Apigenin inqanda ukuhlukana kwee-osteoclasts ukusuka kwimizila yeseli ye-RAW264.7 kwaye emva koko inqanda ukubunjwa kwee-osteoclasts ezininzi.Isenokwenza i-osteoclast apoptosis kwaye inyanze ukubuyiswa kwamathambo.

Umsebenzi wokulwa nokuvuvukala kunye ne-anti-oxidant

I-Apigenin inqanda inkqubo yokudumba, yonyusa amanqanaba e-IL-10 kwaye ilungelelanise iiparamitha zoxinzelelo lwe-oxidative.

I-Apigenin inqanda i-cytokines e-pro-inflammatory kwaye yenza ukuveliswa kwe-cytokine echasayo.

Olunye uncwadi lucebisa ukuba i-apigenin inciphisa ukudumba kwezicubu okubangelwa luxinzelelo lwe-oxidative kwizicubu ngokumodareyitha iimpawu ezahlukeneyo zoxinzelelo lwe-oxidative, i-interleukins, iziphawuli ze-enzyme yegazi, kunye nokubonakaliswa kwezinye ii-enzymes ezininzi ezinxulumeneyo.

Ukulawulwa kwe-endocrine

I-Apigenin inokulawula iswekile yegazi, iphathe ukusilela kwe-thyroid kunye nokulawula i-lipid peroxidation.Kwafunyaniswa ukuba i-apigenin inokunyusa amanqanaba e-insulin kunye ne-thyroxine kwizilwanyana ezinesifo seswekile, kwaye inciphise ukuxinana kweswekile yegazi kunye nomsebenzi we-glucose-6-phosphorylase (G- 6-Pase).

I-Apigenin iguqule imiphumo yokunyuka kwe-cholesterol ye-serum, ukunyuka kwesibindi se-lipid peroxidation (LPO) kunye nokunciphisa imisebenzi ye-antioxidants efana ne-catalase (CAT) kunye ne-superoxide dismutase (SOD) kwizilwanyana ezibangelwa yi-alloxan.

Kwizilwanyana ezineswekile yegazi rhoqo, i-apigenin inokunciphisa i-cholesterol ye-serum kunye ne-lipid peroxidation yesibindi, kwaye yandise umsebenzi we-antioxidants kwiiseli.

Iimpawu ze-Pharmacological ze-apigenin

I-Apigenin iqhotyoshelwe ngokubaluleka okukhulu kwiminyaka yamuva nje, njengomgqugquzeli wezempilo onenzuzo ngenxa yetyhefu ephantsi ye-intrinsic kunye nemiphumo yayo yezempilo kwiiseli eziqhelekileyo ezichasene nomhlaza, xa kuthelekiswa nezinye i-flavonoids ezinxulumene nesakhiwo.Kukho ubungqina obuninzi bophando olubonise ukuba i-apigenin inamandla amakhulu okunyanga izifo ezininzi

Umsebenzi:

-Ukuthintela ukukhula kweeseli zomhlaza.

-Uxinzelelo lwegazi olusezantsi

-Ikhusela inkqubo ye-cardiovascular system

-Nceda ukulala, ukuzola imithambo-luvo, ukuphelisa ukucaphuka

-Ukuxhathisa ukuvutha

-Thintela i-osteoporosis

-Isiphumo se-diuretic.

-Nqanda ukudityaniswa kweeplatelet.

Isicelo:

-Intsimi yonyango, indawo yokunakekelwa kweMpilo