I-Oleanolic Acid Powder

Oleanolic acid eyi-pentacyclic triterpenoids emithathu ekwanti kwizityalo zeGentianaceae zaseSwertia mileensis yonke ingca okanye isiqhamo seprivet, enomzimba okhululekileyo kunye ne-glycosides kwizityalo ezininzi.I-Oleanolic acid inoluhlu olubanzi kwizityalo, kwaye umxholo oqhelekileyo ngu-0.2% - 2%.I-Cucurbitaceae umxholo ophezulu yi-1.5% ~ hunchback bottom 2%, umxholo we-privet wesiqhamo we-0.6% ~ 0.7%.I-Oleanolic acid luhlobo lwe-pentacyclic triterpenoid ikhompawundi ebekwe yodwa kwisiqhamo sohlobo lwe-Asteraceae, i-Syzygium sylvestris, okanye i-Ligustrum lucidum.Yisincedisi sesifo sesibindi kunye neklinikhi esetyenziselwa usulelo lonyango.I-acute jaundice hepatitis ineempembelelo ezicacileyo ekunciphiseni i-alanine aminotransferase kunye ne-yellowing.Oolic acid yi-pentacyclic triterpenoids esecaleni kwisiqhamo se-swertia chinensis okanye i-fructus ligustris kwisityalo se-gentianaceae.I-Oleanolic acid ifumaneka ngokubanzi kwizityalo, kunye nomxholo jikelele we-0.2% ~ 2% [1].Umxholo wecalabash wawuyi-1.5% ~ 2%, kwaye umxholo wefructus ligustris wawuyi-0.6% ~ 0.7%.Iasidi yeOleanolic yikristale emhlophe ye-acicular (ethanol), ayinavumba kwaye ayinancasa.Ukungazinzi kwiiasidi kunye neziseko.Indawo yokunyibilika ye308 ~ 310 ℃, [alpha] 20 d + 73.3 ° (c = 0.15, chloroform, ayinyibiliki emanzini, inyibilika kwimethanol, ethanol, ethyl ether, acetone kunye chloroform.Oleanolic acid yi-tripenoid eyenzeka ngokwendalo, ukutya kunye nezityalo zonyango, ezinxulumene ne-betulinic acid Inokufumaneka kwi-Phytolacca americana (i-American pokeweed), kunye ne-Syzygium spp, i-garlic, njl.
Iasidi yeOleanolic yafunyanwa ibonakalisa umsebenzi oqinileyo wokuchasana ne-HIV, i-asidi enxulumene ne-betulinic yasetyenziswa ukwenza ichiza lokuqala lokuvuthwa kwe-inhibitor.Yaqala yafundwa kwaye yahlukaniswa nezityalo ezininzi, kuquka iRosa woodsii (amagqabi), iProsopis glandulosa (amagqabi kunye namasetyana), Phordendron juniperinum (isityalo sonke), iSyzygium claviflorum (amagqabi), Hyptis capitata (isityalo sonke), kunye neTernstromia gymnanthera (emoyeni). inxalenye).Ezinye iintlobo zeSyzygium eziquka iapile yejava (Syzygium samarangense) kunye ne rose apples ziqulathe.

Igama leMveliso:Oleanolic Acid98%

Inkcazo:98% yi-HPLC

Umthombo weBotanic:Olea Europea Extract

Igama leMchiza:(3β)-3-Hydroxyolean-12-en-28-oic acid

Inombolo yeCAS:508-02-1

Icandelo elisetyenzisiweyo:Igqabi

Umbala: Umgubo omhlophe kunye nevumba elibonakalayo kunye nencasa

Isimo se-GMO:GMO Mahala

Ukupakisha: kwi-25kgs fiber drums

Ugcino: Gcina isikhongozeli singavulwanga kwindawo epholileyo neyomileyo, Zigcine kude nokukhanya okuqinileyo

Ubomi beShelf: iinyanga ezingama-24 ukusuka kumhla wokuvelisa

Yintoni ii-oleanolic acid?

I-Oleanolic acid (OA), i-hydroxyl pentacyclic triterpenoid acid (HPTA) yendalo efana ne-betulinic acid, i-ursolic acid;ineenzuzo ezifana ne-antibacterial, anti-inflammatory, antitumor activities.

Ungayifumana phii-oleanolic acid?

I-Oleanolic acid isetyenziswe ngokwesiko kunyango lwezifo ezahlukeneyo, unokuyifumana ekutyeni nakwizityalo ngokubanzi.

Ezinye iziqhamo ezifana nama-apile, irharnati, ilamuni, iibhilberries, iminquma iqulethe i-oleanolic acid nayo.

Okwangoku, isityalo saseTshayinaHemsley Chinansis Cogniseyeyona imathiriyeli yokurhweba yokukhupha i-oleanolic acid.

Hemsley Chinansis Cogn.Intshayelelo

Hemsleya chinensis Cogn.liyeza elihlala linyuka, ikwaliyeza lesiNtu lamaTshayina.

Intsapho: Cucurbitaceae

Tribus: Gomphogyneae

Uhlobo: Hemsleya

Iintlobo: H. amabilis

I-herb isasazwa kumaphondo e-Guangxi, eSichuan, eGuizhou, eYunnan, eHubei, njl.

Izithako ezisebenzayo: iqulethe iHemslolide Mal, Ma3, H1;Chikusesusaponin-Iva;i-dihydro cucurbitacin F-25-acetate;dilydrocucurbitacin F;i-oleanolic acid-beta-Hlucosyloleanolate;Hemsamabilinin A;Cu-curbitacinⅡb-2-beta-D-glucopyranoside.

Amaxabiso amayeza:

Hemsleya chinensis Cogn.ikakhulu yeyokukhupha ubutyhefu, ukuvala inzala, ukuchasana nokudumba, ukomeleza isisu kunye nokuphelisa iintlungu.Okwangoku, kukho i-extracts powder, okanye amalungiselelo adibeneyo afana nee-capsules, iipilisi, iipilisi zesisu, njl., Ezisetyenziswa ngokubanzi kwiiklinikhi.

Ukukhutshwa kwe-Oleanolic acid ukusukaHemsleya Chinensis Cogn.

Iifomula eziqulethe i-Oleanolic acid kwizongezo zokutya

Sifumene ukuba i-oleanolic acid esetyenziswa kwizongezo zezempilo ikakhulu ivela kwiintlobo ezintathu zezityalo ezicatshulwayo: i-Loquat leaf extract, i-Hemsley Chinensis extract, kunye nesicatshulwa esingcwele se-basil.

• I-Holy Basil powder (iqabunga) (0.4% Ursolic acid kunye ne-Oleanolic acid, 2.0 mg)
• I-Holy Basil supercritical isicatshulwa se-CO2 (igqabi) (i-Ocimum tenuiflorum Linn.) (2.5% i-Ursolic acid kunye ne-Oleanolic acid, i-1.5 mg)
• I-Loquat Extract (isiqhamo) (ukubonelela nge-Ursolic acid, i-Oleanolic Acid) (eMiselweyo kwi-Ursolic acid ngokukhonza i-125mg)

Oleanolic acid VS Ursolic acid

I-Oleanolic acid (OA) kunye ne-ursolic acid (UA) zi-triterpenoids zendalo ezinokwakheka kweekhemikhali ezifanayo.

Ezi khompawundi ze-triterpenoids ziyaziwa ukuba zikhona kumayeza okutya kunye nokutya.

Zinezinto ezininzi eziqhelekileyo ze-pharmacological: i-hepatoprotective, anti-inflammatory, antimicrobial, hypoglycemic, antimutagenic, anti-HIV umsebenzi, i-antioxidant, kunye nemisebenzi ye-antifertility.

Umahluko we-OA kunye ne-UA:

Imisebenzi ye-Biological ye-Oleanolic Acid

1. I-Anti-Tumor / Anti-Cancer Effects

Isiphumo sokuthintela i-oleanolic acid kwi-hepatocellular carcinoma nge-ERK-p53-mediated cell cycle ukubanjwa kunye ne-apoptosis exhomekeke kwi-mitochondrial

– nguXin Wang, Hua Bai, njl Abaphandi

I-OA ibonise impembelelo yokuthintela kwi-HCC ngokungeniswa kwe-apoptosis kunye nokubanjwa komjikelo weseli kuzo zombini iiseli ezitshintshiweyo kunye neeseli ze-HepG2.

I-OA ibangele i-apoptosis ngokusebenzisa indlela ye-mitochondrial, ibonakaliswe ngokuvinjelwa kwe-Akt / mammalian ekujoliswe kuyo ye-rapamycin indlela.

I-OA ibangele ukubanjwa kwe-G2 / M ye-cell cycle cycle ngokusebenzisa i-p21-mediated down-regulation ye-cyclin B1 / cdc2.

I-OA ibonise imisebenzi ebalulekileyo ye-antitumor kwi-HCC kwi-vivo kunye ne-in vitro model.Ezi nkcukacha zibonelela ngengqiqo entsha kwiindlela eziphantsi kwempembelelo ye-antitumor ye-OA.

Ukongeza, uphando lubonisa ukuba i-OA kunye ne-Oleanolic acid methyl ester ephuma kuyo ineziphumo kumhlaza wamabele, umhlaza wemiphunga, umhlaza wesinyi, umhlaza womlomo wesibeleko, iiseli zomhlaza wepancreatic…

2. Umsebenzi we-Antimicrobial

I-OA kulindeleke ukuba ibe nomsebenzi wokulwa neentsholongwane ezilwa noluhlu olubanzi lweentsholongwane ezibangela izifo kuba idlala indima ebalulekileyo ekukhuseleni iintsholongwane kwizityalo.

I-OA ibonise umsebenzi ophakathi ngokuchasene ne-Staphylococcus aureus kunye ne-Bacillus Thuringiensis kwi-62.5 µg/mL kunye ne-Escherichia coli, i-Salmonella Enterica, kunye ne-Shigella dysenteriae kwi-31.2 µg/mL ubuncinci be-inhibitory concentration (MIC).

3. Ubunakho beHepatoprotective

Enye yezinto ezibalulekileyo ze-OA kukhuseleko lwesibindi kwityhefu kwaye ngoku isetyenziswa njengechiza elichasene ne-hepatic counter e-China.

Kwiigundane ze-Wistar albino, i-OA esuka kwi-Flaveria Trinervia isetyenzisiwe kwaye yayinempembelelo ebalulekileyo yokukhusela kwi-ethanol-induced yesibindi yetyhefu ngokubuyisela i-hepatotoxic serum marker enzyme amanqanaba.Olu phononongo luphakamise isakhono se-antioxidant se-OA njengenye indlela enokwenzeka yesakhono sayo se-hepatoprotective.

I-Oleanolic Acid kunye nezinto eziphuma kuyo

Iimvavanyo zeklinikhi ye-Oleanolic Acid

I-Oleanolic acid (ethathwe kumnquma), kukho malunga ne-500 yolingo lwekliniki olubhalisiweyo, lubonise ukuba luneziphumo eziluncedo kwiimvavanyo zeklinikhi kwisifo sezintso esingapheliyo, isifo sikashukela sohlobo lwe-2, kunye nezinye iimeko ezivuthayo ezifana nesifo samathambo.

Uninzi lwezinto eziphuma kuzo kwizilingo zeklinikhi yi-bardoxolone methyl (CDDO-Me).I-CDDO-Me yavavanywa kwi-tumor biopsies, kwaye ingakwazi ukudlala indima kunyango lwesifo sezintso esinganyangekiyo, ngoku iyavavanywa kwiziphumo zoxinzelelo lwegazi.

Umgangatho waseTshayina we-Pharmacopoeia we-Oleanolic Acid

I-Oleanolic acid incoma umthamo

Ngokutsho kwe-Chinese Pharmacopoeia Standard, i-Oleanolic acid Oral dose yi-20 ~ 80mg ngexesha, i-60 ~ 240mg ngosuku.

Imiphumo emibi ye-Oleanolic acid

Iasidi yeOleanolic esetyenziswa njengeyeza elingaphezulu kwekhawuntara (OTC) hepatoprotective yeziyobisi kangangamashumi eminyaka eTshayina.

Ukuba i-overdose okanye ayichanekanga, inani elincinci lezigulane ezinomlomo owomileyo, isifo sohudo, ukuphazamiseka kwesisu esiphezulu, kwaye sinokunyamalala emva kokunyanga kweempawu.

Nceda udibane nogqirha wakho okanye usokhemisti ngaphambi kokusebenzisa le mveliso.

Umsebenzi:

I-asidi ye-1.Oleanolic ayinayo ityhefu, i-antitumor, kunye ne-hepatoprotective, kunye nokubonisa iimpawu ze-antiviral.
I-2.Oleanolic acid yafunyanwa ukubonisa umsebenzi onamandla wokulwa ne-HIV.
I-3.Oleanolic acid ngumkhuseli omkhulu weeseli ezichasene ne-oxidative kunye ne-electrophile stress.
4.Oleanolic acid inefuthe elikhulu trating virus hepatitis, acute icteric hepatitis kunye hepatitis ezingapheliyo.
Isicelo:
1. Ukusetyenziswa kwintsimi yokutya, inokusebenza njengezinto eziluhlaza zeti ukunciphisa i-phlegm;
2. Isetyenziswe kwintsimi yamachiza, iba lichiza elitsha lokulwa nomhlaza elinetyhefu ephantsi;
3. Ukusetyenziswa kwintsimi ye-cosmetic, inokuvuselela ukujikeleza kwegazi kunye nokususa isiselo.