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INicotinamide mononucleotide umgubo omninzi
Igama lemveliso:I-Nicotinamide mononucleotide powder
Izithethantonye: NMN,β-Nicotinamide Mononucleotide,beta-Nicotinamide Mononucleotide
Inombolo yeCAS: 1094-61-7
Iinkcukacha: 99% min
Ifomula yeemolekyuli: C11H15N2O8P
Ubunzima beMolekyuli: 334.221 g/mol
Iphakheji: 1kg/bag, 25kg/drum
Yintoni iNicotinamide Mononucleotide?
INicotinamide mononucleotide, efinyeziweyo njengeNMN, inala magama alandelayo:
β-NMN, BETA-Nicotinamide Mononucleotide;
I-BETA-NMN;I-BETA-NICOTINAMIDE MONONUCLEOTIDE;
I-BETA-NICOTINAMIDE RIBOSE MONOPHOSPHATE;
I-NICOTINAMIDE-1-IUM-1-BETA-D-RIBOFURANOSIDE 5′-PHOSPHATE;I-NICOTINAMIDE RIBOTIDE;
NICOTINAMIDE MONONUCLEOTIDE
I-NMN ikhona kwizinto eziphilayo ezahlukeneyo kuquka abantu kwaye iyimfuneko ekugcinweni kwemisebenzi yomzimba.I-NMN iphinda isetyenziswe emva kokuba yenziwe i-metabolized ngumzimba, kwaye i-vitamin B3 ekutyeni inokuphinda idibanise i-NMN.
Ngaphambi kokuba siqonde i-nicotinamide mononucleotide, kufuneka siyazi ukuba yintoni na.INicotinamide mononucleotide (NMN) sisiqalo esibalulekileyo se-NAD+, kwaye i-NAD+ yeyona ndlela ibalulekileyo yokulungisa iiseli ebantwini.Xa abantu beseziintsana nakubantwana abancinci, ukukhula kunye nokukhula kwabo kukhawuleza kakhulu, kwaye ngokukhula kweminyaka, umsebenzi womzimba womntu uya kuncipha ngokuthe ngcembe.Umzekelo olula ufana nomdala;uya kumfanyekiswa ngengozi.Amaqhuma adilizwa, yaye okubi nangakumbi kukuba benzakala kakhulu.Kwinkqubo yokuguga kweeseli zomntu, inani le-NAD+ liya kuncitshiswa kakhulu xa lithelekiswa nexesha elidlulileyo ngenxa yemetabolism kunye nomzimba ngokwawo.
INicotinamide mononucleotide yinxalenye ebalulekileyo yokuvuselelwa komntu.Izazinzulu kwihlabathi liphela ziye zafumanisa ukuba i-nicotinamide mononucleotide inefuthe elithile ekwaluphaleni.Kuphando olunzulu, isitshixo se-nicotinamide mononucleotide kukuba yi-precursor ye-NAD +, eya kuguqula i-NAD +, yongeze into yokulungisa iiseli kwiiseli zomntu, ixhathise inkqubo yokuguga, kwaye ibe nethuba lokuqalisa kwakhona umsebenzi wokukhula kwakhona. iseli, engumsebenzi wokwandisa ubomi be-nicotinamide mononucleotide.
INicotinamide mononucleotide ikho ngokwendalo kwiseli nganye yomzimba wethu kwaye licandelo elibalulekileyo lokuzilungisa komzimba.Yimetabolite yokugcina i-NAD + biosynthesis eqhelekileyo, kwaye le nto inokulawula i-physiology ngexesha lokujikeleza komzimba, nakwi-pathology ethile.Idlala indima ebalulekileyo ekusebenzeni kweeseli.
Izongezo eziqulathe i-NMN
Zininzi iimveliso ze-NMN ezithengiswayo ngoku.Ezinye zithandwa phakathi kwabasebenzisi bokugqibela, njenge-NMN Pure, i-Ultra NMN, njl njl kwi-Amazon nakwezinye iivenkile ze-intanethi.
Ezinye iifomyula zine-NNN kuphela kuyo, kwaye ezinye zidibene kunye nezinye izithako ezichasene nokuguga, ezifana ne-resveratrol, i-pterostilbene, ibonise ingcambu yengcambu, njl.
Zombini iifom ze-capsule kunye ne-tablet ziyafumaneka, ngezantsi ziinyaniso zoncediso lwe-NMN kwezinye iilebhile ze-NMN:
I-125mg ibonakala iyisilinganisi esithandwayo sezongezelelo ezininzi ze-NMN, nangona abanye bebhala i-260mg nge-capsule nganye kwiilebhile zabo kunye nobukhulu bokukhonza ii-capsules ze-2 okanye iipilisi imihla ngemihla.Akukho mthamo ucetyiswayo ngokusemthethweni.
Indlela yokwenza i-nicotinamide mononucleotide
I-nicotinamide mononucleotide iguqulelwa ekubeni “yi-nicotinamide adenine dinucleotide (NAD)” into ebalulekileyo kumetabolism yamandla emzimbeni.Kuvavanyo lwempuku, kwaqinisekiswa ukuba i-nicotinamide mononucleotide inokuvula ufuzo olubizwa ngokuba yi-acetylase emzimbeni, ngokwenza oko iveze iziphumo ezinjengokwandisa ubomi kunye nokunyanga isifo seswekile.I-NAD yinto enokuveliswa ngumzimba womntu.Uphononongo lubonise ukuba umxholo we-NAD emzimbeni wehla ngeminyaka.
Ukwanda kokuvuvukala okuhambelana nokuguga kunokuphazamisa amandla omzimba wokuvelisa i-NMN, nto leyo ebangela ukuhla kwe-NAD.
I-NMN yinto engaphambili ye-coenzyme NAD+ ebalulekileyo emzimbeni.INicotinamide mononucleotide yindima ebalulekileyo kwimveliso yamandla eeseli zabantu, kwaye ibandakanyeka kwi-synthesis ye-intracellular NAD+ (nicotinamide adenine dinucleotide, i-coenzyme yokuguqulwa kwamandla eseli).
I-NMN yamkelwa ngokusemthethweni njengento yokuqala yehlabathi engqinisiswe ngamalingo angqongqo enzululwazi ukubuyisela umva ngokufanelekileyo kunye nokulibazisa ukuguga nokwandisa ubomi.
Kwi-2017, izifundo zibonise ukuba i-NMN inokunyanga i-NR kunye ne-NMN ataxia, kwaye i-NR ayitshintshi umsebenzi we-SIRT3 okanye iphucule umsebenzi wenhliziyo.
Unikezelo lwe-NAD + aluyi kumisa - luya kuqhubeka ludliwa kwaye luzaliswe, kwaye yonke i-NAD + ichibi ijikeleza amaxesha angama-2-4 ngosuku.
Lo mjikelo uhamba ngeendlela zokulungisa, apho i-enzyme i-Nampt ivuselela i-NAM ukuya kwi-NMN kwaye emva koko i-metabolise kwi-NAD +.I-Namp linyathelo elinciphisa isantya kwinkqubo yokuloba.
INicotinamide Mononucleotide VS.Nicotinamide Riboside
Namhlanje, ihlabathi lizizityebi kuphando olwahlukeneyo nge-NR, kwaye uvavanyo lomzimba womntu lwenza umphumo we-NR kwidatha yethiyori ibe ngcono kune-NMN.Nangona kunjalo, uphando lubonise ukuba i-NR iqala ukusebenza emzimbeni womntu kwaye isafuna ukuba namava okwethutyana.Isitshixo kukuba zombini i-NR kunye ne-NMN zi-precursors ze-NAD +, ngelixa i-Nicotinamide Riboside (NR) isandulela se-NMN kunye ne-NAD +, ngoko i-NR iyatshintsha.Kuthatha ixesha ngaphambi kweNAD +.Xa kuthelekiswa nesiphumo esikhawulezileyo se-NMN, imizuzu ye-15 ye-NR yi-gap enkulu.
Inokubonwa kulo mjikelo ungentla ukuba i-NAMPT yinto ebalulekileyo ethintela ukuveliswa kwe-NMN.Njengoko ubudala bukhula, kungekhona umzimba womntu ongafuni ukuba mncinci, kodwa umsebenzi we-enzyme ye-NAMPT uyancipha xa amandla kunye nezondlo zinikezelwa.Njengoko umjikelo we-NAM uncitshisiwe, isitokhwe se-NAD + siyancipha ngokwendalo.
I-NR ingaguqulelwa kwi-NMN okanye kwi-NAM, kuxhomekeke kwindima ye-Nrk1 enzyme ukumisela ukuba yeyiphi into yomgangatho ofanayo we-NR eya kuvelisa ngaphezulu.Ukuba iguqulelwe kwi-NAM, ikwathintelwa yi-NAMPT enzyme.Xa kuthelekiswa nesenzo esithe ngqo se-NMN ukuvelisa i-NAD +, umphumo wexabiso elilinganayo le-NR ngokucacileyo ubuthathaka kakhulu.
Kutheni ungathathi i-NAD +?
I-NAD + ayinakuthatyathwa ngokuthe ngqo kwiiseli ngolawulo lomlomo ngenxa yobunzima bayo bemolekyuli.Ukongezwa kwe-NAD + kufezwa kuphela ngokungenisa isandulela esincinci semolekyuli ye-NAD +.
Nangona kunjalo, i-NMN inokwenziwa kwiimveliso ezahlukeneyo, ezinokuthi zibe ngamacwecwe, iipilisi, okanye iigranules ngenxa yobume bayo obunyibilikayo.Ukunyibilika kwe-NMN emanzini yi-35mg/ml.
Ngale ndlela, i-NMN ingcono kakhulu kune-NAD+, kwaye ithe ngqo ngakumbi kune-nicotinamide riboside.
Iinzuzo zeNicotinamide Mononucleotide
Iziphumo eziphambili ze-NMN zezi zilandelayo:
- i-anti-oxidation
- Ukuphelisa ukwehla ngokwasemzimbeni
- Ukulungiswa kweDNA
- Ukuxhasa iziphumo ze-neuroprotective
- Ukuphucula ukusebenza kwentliziyo kunye nokukhusela intliziyo
- Ukuphucula imeko yezigulane ze-Alzheimer
Olona phawu lwahlukileyo lwe-NMN kukuba lunokukubuyisela umva ukwaluphala nokwandisa ubomi.
I-Nicotinamide Mononucleotide iziphumo ebezingalindelekanga
Ekubeni i-NMN okwangoku iqhuba kuphela iimvavanyo zezilwanyana, iimvavanyo ezinkulu zabantu azikaqalisi, ngoko ke iziphumo ezichaphazelekayo ezinokugqitywa azikacaci.Nangona kunjalo, ngokwendlela yokusebenza kwe-NMN, kunokuchazwa ukuba izigulane ezinomhlaza akufanele zithathe kangangoko kunokwenzeka.Ngenxa yokuba inguqu ye-NMN ikhuthaza ukuveliswa kwe-NAD +, ngelixa iiseli zomhlaza ziqhelana nemisebenzi ecothayo ye-physiological, ukonyuka kwemetabolism kunokubangela ukusasazeka kweeseli ezithile zomhlaza.
Xa usebenzisa izongezelelo ze-nicotinamide nucleoside ezifana ne-NMN, ukusebenza komthambo kunokuchaphazeleka.Kwiimpuku, iimpuku ezitofwe ngezongezo ze-NAD + zibonise ukusebenza okuncinci kakhulu kuneqela labo lolawulo.
