I-PRL-8-53

I-PRL-8-53, i-nootropic entsha, eyaziwa nangokuthi igama layo lekhemikhali i-Methyl 3- [2- [benzyl (methyl) amino] ethyl] i-benzoate i-synthetic nootropic supplement.Yaphuhliswa ngeminyaka yoo-1970 nguGqr. Nikolaus Hansl kwiYunivesithi yaseCreighton eNebraska.Ibe nezifundo ezithile zabantu ezibonise iimpendulo ezilungileyo ekusebenzeni kwengqondo.Olunye uphando lubonise ukuba ikhompawundi inokunceda ukubuyisela iinkumbulo ezilahlekileyo (hypermnesia).

Igama lemveliso:PRL-8-53

Elinye Igama:Methyl 3-(2-(benzylmethylamino)ethyl)benzoate hydrochloride

3-(2-benzylmethylaminoethyl) benzoic acid methyl ester hydrochloride

3-(2-(Methyl(phenylmethyl)amino)ethyl)benzoic acid methyl ester hydrochloride

Inombolo yeCAS : 51352-87-5

MF:C18H21NO2

Uvavanyo: 98%

Imbonakalo: Umgubo omhlophe

Isebenza Njani I-PRL-8-53?

I-PRL-8-53 ivela kwindibaniselwano ye-benzoic acid kunye ne-phenylmethylamine.Ukwakhiwa kweekhemikhali ezenziwe ngokudityaniswa kwezi zimbini zikhokelela kwikhompawundi enokuthi idibanise ne-cholinergic receptors, ebandakanyekayo ekumodareyitheni imemori kunye neenkqubo zokufunda ngaphakathi kwengqondo.I-PRL-8-53 yaziwa ngokuba namandla (ukwandisa umphumo we) i-dopamine kunye nokuthintela ngokuyinxenye i-serotonin receptors.UGqr. Nikolaus Hansl wayekholelwa ukuba le nkcazo yempembelelo inokukhokelela ekutshintsheni kwebhalansi kwiinkqubo ze-CNS neurotransmitter kwaye zikhokelele ekuphuculeni ukusebenza kwengqondo.

Kukho uphando olulodwa lwekliniki lwabantu olulungiselelwe ukuvavanya imiphumo yechiza kwaye lubonise ukuphucuka kwimemori yomlomo, ixesha lokuphendula okubonakalayo kunye nokulawulwa kwemoto, ngakumbi kwabo baneminyaka engama-30 ubudala. kunye nokuncipha kwengqondo, ke ngoko, inkumbulo kunye nezongezelelo zokuphucula ingqondo zidla ngokusebenza ngcono kuzo.

RPL-8-53 Imisebenzi:

Ukwandisa ubukrelekrele bengqondo

Khulisa inkumbulo kunye nezakhono zokuthembela

Ukuphucula amandla obuchopho ukusombulula iingxaki kunye nokukhusela kuyo nayiphi na imichiza okanye ukwenzakala emzimbeni

Ukwandisa inqanaba lenkuthazo

Ukuphucula ulawulo lwecortical/subcortical brain mechanism

Phucula ingqiqo yeemvakalelo

Umthamo kunye neziphumo ebezingalindelekanga

Ulwazi lwe-patent ekhoyo kwi-PRL 8-53 iphakamisa uluhlu lwe-0.01-4mg / kg ye-bodyweight.Nangona kunjalo, njengoko luhlu olukhulu kakhulu, uluhlu olufanelekileyo luyi-0.05-1.2 mg / kg.Oku kuguqulela kwi-3.4mg-81.6mg kumntu we-pound ye-150 kunye ne-4.55mg-109mg kumntu we-pound ye-200.Kulingo lomntu, akukho ziphumo ebezingalindelekanga zabhalwa;nangona kunjalo, umsebenzi oncitshisiweyo wemoto waphawulwa kwiigundane kunye neegundane xa zinikwa iidosi ezinkulu ze-PRL 8-53