I-Adenosine iyi-nucleoside ye-purine eyakhiwe i-molecule ye-adenine exhunywe ku-ribose sugar molecule (ribofuranose) moiety nge-β-N9-glycosidic bond.I-Adenosine itholakala kakhulu emvelweni futhi idlala indima ebalulekile ezinqubweni zamakhemikhali ezinto eziphilayo, njengokudluliswa kwamandla - njenge-adenosine triphosphate (ATP) ne-adenosine diphosphate (ADP) - kanye nokudluliswa kwesignali njenge-cyclic adenosine monophosphate (cAMP).Futhi iyi-neuromodulator, okukholakala ukuthi idlala indima ekukhuthazeni ukulala kanye nokucindezela ukuvuka kwenkanuko.I-Adenosine nayo idlala indima ekulawuleni ukugeleza kwegazi ezithweni ezihlukahlukene ngokusebenzisa i-vasodilation.
Igama Lomkhiqizo:I-Adenosine
Elinye Igama:I-Adenine riboside
Inombolo ye-CAS: 58-61-7
I-Molecular Formula: C10H13N5O4
Isisindo se-molecule: 267.24
I-EINECS NO.: 200-389-9
Iphoyinti lokuncibilika: 234-236ºC
Ukucaciswa:99%~102% nge-HPLC
Ukubukeka:Impushana Emhlophe enephunga elibonakalayo kanye nokunambitha
Isimo se-GMO:GMO Mahhala
Ukupakisha: ku-25kgs fiber drums
Isitoreji: Gcina isitsha singavulwa endaweni epholile, eyomile, gwema ukukhanya okuqinile
Impilo Yeshelufu: Izinyanga ezingama-24 kusukela ngosuku lokukhiqiza
Umsebenzi:
-I-Adenosine iyi-nucleoside engapheli kuwo wonke amangqamuzana omuntu ngqo ku-myocardium nge-phosphorylation ikhiqiza i-adenylate ehilelekile ku-myocardial energy metabolism.I-Adenosine nayo ihambela ukwanda kwemithambo yenhliziyo, ikhulisa ukugeleza kwegazi.
-I-Adenosine idlala indima engokomzimba ohlelweni lwenhliziyo nemithambo yegazi nezinhlelo eziningi nezinhlangano zomzimba.I-Adenosine isetshenziswa ku-synthesis adenosine triphosphate, adenosine (ATP), i-adenine, i-adenosine, i-vidarabine ebalulekile ephakathi.
Indlela
I-Adenosine idlala indima ebalulekile ku-biochemistry, okuhlanganisa i-adenosine triphosphate (ATP) noma i-adeno-bisphosphate (ADP) uhlobo lokudluliselwa kwamandla, noma ku-cyclic adenosine monophosphate (cAMP) yokudlulisa isignali nokunye.Ngaphezu kwalokho, i-adenosine iyi-neurotransmitter evimbelayo (i-neurotransmitter evimbelayo), ingase ikhuthaze ukulala.
Ucwaningo Lwezemfundo
Kumagazini wango-December 23 “wemvelo – Medicine” (Nature Medicine), ucwaningo olusha lubonisa ukuthi inhlanganisela izosisiza ekudambiseni ubuchopho bokulala kanye nezinye izifo zobuchopho I-Parkinson’s disease Ukuvuselela ubuchopho obujulile bempumelelo kubalulekile.Lolu cwaningo lubonisa ukuthi: ubuchopho obuthongo bungaholela ekwakhiweni - i-Adenosine iwumphumela ojulile wokuvuselela ubuchopho (DBS) wokhiye.Ubuchwepheshe bokwelapha isifo sikaParkinson kanye neziguli ezinokuthuthumela okukhulu, le ndlela nayo yazanywa ekwelapheni ukucindezeleka okukhulu.
