I-Azelaic Acid 98%nge-HPLC | Ibanga Lezemithi Nelezimonyo
1. Uhlolojikelele lomkhiqizo
I-Azelaic Acid(I-CAS123-99-9) i-dicarboxylic acid egcwele ngokwemvelo enefomula ye-molecular C₉H₁₆O₄ kanye nesisindo se-molecular 188.22 g/mol. Ibanga lethu lokuhlanzeka eliqinisekiswe i-HPLC elingu-98% lihlangabezana namazinga e-USP/EP, alungiselelwe ukwakheka kwesikhumba nezinhlelo zokusebenza zezimboni .
Imininingwane Ebalulekile
- Ubumsulwa: ≥98% (HPLC-ELSD iqinisekisiwe, ukungcola okuphelele <0.2%)
- Ukubukeka: I-crystalline powder emhlophe
- Indawo encibilikayo: 109-111°C
- Indawo yokubilisa: 286°C ku-100 mmHg
- Ukunyibilika: 2.14 g/L emanzini (25°C), kuncibilika kuzisombululo ze-ethanol/alkaline
2. I-Chemical Characterization
2.1 Ukuqinisekiswa Kwesakhiwo
- Iphrofayela ye-NMR:
¹H NMR (300 MHz, CDCl₃): δ 1.23 (t, J=7.1Hz, 3H), 1.26-1.39 (m, 6H), 1.51-1.69 (m, 4H), 2.26/2.32 (q, 4.10 Hz), ngayinye s, COOH) - I-HPLC Chromatogram:
Isikhathi Sokugcina: 20.5 amaminithi (ukuphakama okukhulu), ukungcola kuphakeme <0.1% ku-31.5/41.5 min
2.2 Iphrothokholi Yokulawula Ikhwalithi
| Ipharamitha | Indlela | Imibandela Yokwamukela |
|---|---|---|
| Isivivinyo | I-HPLC-ELSD (Agilent 1200) Ikholomu: I-Purospher Star RP-C18 Isigaba Seselula: I-Methanol/Water/Acetic Acid gradient | 98.0-102.0% |
| Izinsimbi Ezisindayo | I-ICP-MS | ≤10 ppm |
| Izincibilikisi Ezisele | I-GC-FID (ikholomu ye-HP-5MS) Ukukhipha nge-HMDS | I-Ethanol <0.5% |
3. Izicelo Zemithi
3.1 Ukusebenza Kwesikhumba
- I-Acne Vulgaris:
Yehlisa ama-comedones ngo-65% ezivivinyweni zamasonto ayi-12 (ukhilimu ongu-20%) ngokusebenzisa:- Isenzo se-antimicrobial ngokumeleneC. izinduna(MIC₅₀ 256 μg/mL)
- I-Tyrosinase inhibition (IC₅₀ 3.8 mM) ye-post-inflammatory hyperpigmentation
- I-Rosacea:
Ijeli engu-15% ikhombisa ukwehla ngo-72% ku-erythema (vs 43% placebo) ngokusebenzisa:- I-Antioxidant ROS scavenging (EC₅₀ 8.3 μM)
- Ukucindezelwa kwe-MMP-9 kuma-keratinocyte
3.2 Imihlahlandlela Yokwakha
| Ifomu Lomthamo | Kunconyiwe % | Amanothi Ahambisanayo |
|---|---|---|
| Ukhilimu/Ijeli | 15-20% | Gwema i-methylparaben (ibangela ukuwohloka okungu-42%) |
| I-Liposomal | 5-10% | Sebenzisa i-phosphate buffer pH7.4 + lecithin yesoya |
4. Izicelo zezimonyo
4.1 I-Whitening Synergy
- Inhlanganisela Elungile:
- 2% AzA + 5% Vitamin C: 31% ukunciphisa melanin vs monotherapy
- 1% AzA + 0.01% Retinol: 2x collagen synthesis boost
4.2 Idatha Yokuzinza
| Isimo | Izinga Lokwehliswa |
|---|---|
| 40°C/75% RH (3M) | <0.5% |
| Ukuvezwa kwe-UV | 1.2% (ngokuvikela kwe-TiO₂) |
5. Ukusetshenziswa Kwezimboni
- I-Polymer Precursor:
- Ukuhlanganiswa kwenayiloni-6,9 (isivuno sokusabela> 85% ku-220°C)
- I-Corrosion inhibitor yama-alloys ensimbi (isixazululo esingu-0.1M sehlisa ukugqwala ngo-92%)
6. Ukuphepha Nokulawula
6.1 Iphrofayili Yezobuthi
| Ipharamitha | Umphumela |
|---|---|
| I-Acute Oral LD₅₀ (Igundane) | > 5000 mg/kg |
| Ukucasuka Kwesikhumba | Imnene (OECD 404) |
| Ingozi ye-Ocular | Isigaba 2B |
6.2 Ukuhambisana Nomhlaba Wonke
- Izitifiketi:
- Ifayela le-US FDA Drug Master
- I-EU REACH Ibhalisiwe
- ISO 9001:2015 Uhlelo Lwekhwalithi
7. Ukupakisha & Isitoreji
| Ubuningi | Isitsha | Intengo (EXW) |
|---|---|---|
| 25 kg | Isigubhu se-HDPE + isikhwama se-Alu | $4,800 |
| 1 kg | Ibhodlela lengilazi le-amber | $220 |
| 100 g | Isikhwama esivalwe kabili | $65 |
Isitoreji: 2-8°C endaweni eyomile (igumbi lokushisa liyamukeleka uma <25°C/60% RH)
8. Imibuzo Evame Ukubuzwa
Umbuzo: Ngingasebenzisa i-azelaic acid nge-niacinamide?
A: Yebo, idatha yomtholampilo ikhombisa i-10% AzA + 4% niacinamide ithuthukisa ukubekezelelana ngo-37% vs AzA kuphela
Umbuzo: Iyini impilo yeshelufu?
A: Izinyanga ezingama-36 uma zigcinwe kahle. I-COA eqondene neqoqwana inikeziwe
9. Izikhombo
- Idatha yezinhlamvu ze-NMR
- Indlela ye-HPLC-ELSD
- Izifundo zokuzinza
- Ukusebenza komtholampilo
