I-Tranexamic acid

I-Tranexamic acid Isithombe Esifakiwe
  • I-Tranexamic acid

Incazelo emfushane:

I-Tranexamic acid (ngezinye izikhathi ifushaniswa ibe yi-TXA) umuthi olawula ukopha. Isiza igazi lakho ukuthi lihlule futhi isetshenziselwa ukopha nezikhathi ezinzima. Uma ukhishwa izinyo, ukusebenzisa i-tranexamic acid mouthwash kungasiza ukuyeka ukopha.


  • Intengo ye-FOB:US 5 - 2000 / KG
  • Inani elincane le-oda:1 KG
  • Ikhono Lokuhlinzeka:10000 KG/ngenyanga
  • Imbobo:I-Shanghai / Beijing
  • Imigomo Yokukhokha:L/C,D/A,D/P,T/T,O/A
  • Imigomo Yokuthumela:Ngasolwandle/Ngemoyeni/Nge-Courier
  • I-imeyili:: info@trbextract.com
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    Imininingwane Yomkhiqizo

    Omaka bomkhiqizo

    Igama Lomkhiqizo: Tranexamic Acid 98% by HPLC
    Inombolo ye-CAS:1197-18-8
    I-Molecular Formula: C₈H₁₅NO₂
    Isisindo samangqamuzana: 157.21 g/mol
    Ubumsulwa: ≥98% (HPLC)
    Ukubukeka: I-crystalline powder emhlophe
    Isitoreji: +4°C (isikhathi esifushane), -20°C (isikhathi eside)
    Isicelo: Ezemithi, Izimonyo, Ucwaningo

    1. Uhlolojikelele lomkhiqizo

    I-Tranexamic Acid (TXA), i-synthetic lysine analog, isetshenziswa kabanzi njenge-ejenti ye-antifibrinolytic ukunciphisa ukopha ezilungiselelweni zokuhlinzwa nokuhlukumezeka. Lo mkhiqizo ukhiqizwa ngaphansi kokulawulwa kwekhwalithi okuqinile, okuqinisekisa ukuhlanzeka okungu-≥98% njengoba kuqinisekiswe i-High-Performance Liquid Chromatography (HPLC). Isakhiwo sayo samakhemikhali (trans-4-(aminomethyl)cyclohexanecarboxylic acid) kanye nokuzinza okuphezulu kuyenza ifanelekele ukusetshenziswa okuhlukahlukene, okuhlanganisa:

    • Ukusetshenziswa Kwezokwelapha: Ukulawula ukopha, ukwelashwa kokulimala kwengqondo okubuhlungu (TBI).
    • Izimonyo: Okhilimu abamhlophe besikhumba abaqondise ukuguquguquka kombala.
    • Ucwaningo: Ukuthuthukiswa kwendlela yokuhlaziya kanye nezifundo ze-pharmacokinetic.

    2. Izakhiwo Zamakhemikhali Nezemvelo

    • Igama le-IUPAC: 4-(Aminomethyl)cyclohexane-1-carboxylic acid
    • AMAKHAYA: NC[C@@H]1CCC@HC(=O)O
    • Ukhiye we-InChI: InChI=1S/C8H15NO2/c9-5-6-1-3-7(4-2-6)8(10)11/h6-7H,1-5,9H2,(H,10,11)/t6-,7
    • Indawo Encibilikayo: 386°C (dec.)
    • Ukunyibilika: Kuncibilika emanzini (1N HCl, amabhafa alungiswe i-pH), i-methanol, ne-acetonitrile.

    3. Ukuqinisekisa Ikhwalithi

    3.1 Ukuhlaziywa kwe-HPLC

    Indlela yethu ye-HPLC iqinisekisa ukulinganisa okunembile kanye nephrofayili yokungcola:

    • Ikholomu: XBridge C18 (4.6 mm × 250 mm, 5 μm) noma okulinganayo.
    • Isigaba Seselula: I-Methanol:i-acetate buffer (20 mM, pH 4) (75:25 v/v).
    • Isilinganiso sokugeleza: 0.8–0.9 mL/min.
    • Ukutholwa: I-UV ku-220 nm noma ku-570 nm (i-post-derivatization ne-1% ninhydrin).
    • Ukufaneleka Kwesistimu:
      • Ukunemba: ≤2% CV yendawo ephakemeyo (6 okuphindaphindwayo).
      • Ukubuyisela: 98-102% (80%, 100%, 120% amazinga ama-spiked).

    3.2 Iphrofayili Yokungcola

    • Ukungcola A: ≤0.1%.
    • Ukungcola B: ≤0.2%.
    • Ukungcola Okuphelele: ≤0.2%.
    • I-Halides (njenge-Cl⁻): ≤140 ppm.

    3.3 Ukuzinza

    • I-pH Ukuzinza: Ihambisana nama-buffers (pH 2–7.4) kanye nezixazululo ezivamile ze-IV (isb, i-fructose, i-sodium chloride).
    • Ukuzinza Kokushisa: Izinzile ku-37°C amahora angu-24 kumatikuletsheni webhayoloji.

    4. Izicelo

    4.1 Ukusetshenziswa Kwezokwelapha

    • Ukunakekelwa Kwe-Trauma: Yehlisa ukushona kweziguli ze-TBI ngo-20% (uhlolo lwe-CRASH-3).
    • Ukuhlinzwa: Kwehlisa ukulahleka kwegazi kwe-perioperative (ukuhlinzwa kwamathambo, ukuhlinzwa kwenhliziyo).

    4.2 Izimonyo

    • I-Mechanism: Ivimbela i-plasmin-induced melanogenesis ngokuvimba amasayithi abopha i-lysine.
    • Amafomula: 3% okhilimu be-TXA be-melasma kanye ne-hyperpigmentation.
    • Ukuphepha: Ukusetshenziswa kwezihloko kugwema izingozi zesistimu (isb, i-thrombosis).

    4.3 Ucwaningo Nentuthuko

    • Izindlela Zokuhlaziya:Ukwenziwa: Izifundo zokuguqulwa kwe-Prodrug ngaphansi kwezimo ezine-acidic.
      • I-UPLC-MS/MS: Okokuhlaziya i-plasma (LOD: 0.1 ppm).
      • I-Fluorimetry: Ukukhishwa nge-NDA/CN (ukusabela kwemizuzu emi-5).

    5. Ukupakisha & Isitoreji

    • Ukupakisha Okuyisisekelo: Izikhwama ze-aluminium ezivaliwe ezine-desiccant.
    • Impilo yeshelufu: izinyanga ezingama-24 ku -20°C.
    • Ukuthumela: Izinga lokushisa elizungezile (ligunyazwe amahora angu-72).

    6. Ukuphepha Nokuhambisana

    • Ukubamba: Sebenzisa i-PPE (amagilavu, izibuko) ukugwema ukuhogela/ukuthintwa.
    • Isimo Sokulawula: Ihambisana ne-USP, EP, kanye ne-JP pharmacopeias.
    • Ubuthi: LD₅₀ (ngomlomo, igundane) >5,000 mg/kg; non-carcinogenic.

    7. Izikhombo

    1. Ukuqinisekiswa kokufaneleka kwesistimu kwe-HPLC.
    2. Ijika lokulinganisa kanye namaphrothokholi aphuma kokunye.
    3. Ukuqhathanisa indlela ye-UPLC-MS/MS.
    4. Ukusebenza kwezindleko ekunakekelweni kokuhlukumezeka.
    5. Ukuzinza kokwakheka kwezimonyo.

    Amagama angukhiye: Tranexamic Acid 98% HPLC, Antifibrinolytic Agent, Skin Whitening, Trauma Care, UPLC-MS/MS, CRASH-3 Trial, Melasma Treatment

    Incazelo ye-Meta: I-High-purity Tranexamic Acid (≥98% nge-HPLC) yokusetshenziswa kwezokwelapha, izimonyo, nocwaningo. Izindlela eziqinisekisiwe ze-HPLC, ukunakekelwa kokuhlukumezeka okungabizi kakhulu, kanye nokwakhiwa kwezihloko eziphephile. I-CAS 1197-18-8.

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