Isilimo esidliwayo esinamagatsha anamanzi Extract Apigenin

Phakathi neminyaka embalwa edlule, ibhizinisi lethu lamunca futhi lagaya ubuchwepheshe obuphambili ngokulinganayo ekhaya naphesheya.Khonamanjalo, inkampane yethu inabasebenzi bochwepheshe abazinikele ekuqhubekeleni phambili kwakho Kwekhwalithi Enhle Yase-China Yekhwalithi Engcono Kakhulu Yembewu kaCelery Extract Apigenin, Siyakwamukela ukuthuthukisa ubudlelwano bebhizinisi obuphelele nobunesikhathi eside nebhizinisi lethu ukuze senze ikhono elihle kakhulu komunye nomunye.ukwaneliseka kwamakhasimende kuwumsebenzi wethu waphakade!
Phakathi neminyaka embalwa edlule, ibhizinisi lethu lamunca futhi lagaya ubuchwepheshe obuphambili ngokulinganayo ekhaya naphesheya.Ngaleso sikhathi, inkampani yethu inabasebenzi bochwepheshe abazinikele ekuqhubekeleni phambili kwakhoI-China Apigenin, Umfutho Wegazi Ophansi, “Dala Amanani, Ukukhonza Ikhasimende!”inhloso esiyiphishekelayo.Sithemba ngobuqotho ukuthi wonke amakhasimende azosungula ukusebenzisana kwethu kwesikhathi eside nokuzuzisayo.Uma ufisa ukuthola imininingwane eyengeziwe mayelana nenkampani yethu, Kufanele uxhumane nathi manje!
I-Apigenin, njenge-bioflavonoid eyaziwayo, iboniswe ukuthi ibonise imisebenzi ehlukahlukene yezinto eziphilayo, kuhlanganise ne-antioxidant, anti-inflammatory, antitumor, ant-genotoxic, anti-allergic, neuroprotective, cardioprotective, kanye ne-antimicrobial.Nokho, Omunye wemithombo evame kakhulu ye-apigenin isilimo esidliwayo esinamagatsha anamanzi (Apium graveolens), isitshalo sexhaphozi emndenini we-Apiaceae esitshalwe njengemifino kusukela kudala.I-Apigenin iyisakhi esikhishwe kakhulu ku-celery, equkethe i-apigenin engu-108 mg nge-kg.I-Apigenin ingenye ye-flavonoids yokudla evamile, etholakala kakhulu ezithelweni eziningi, imifino, namakhambi okwelapha.Isebenza imisebenzi ehlukahlukene yomzimba, njenge-antioxidant, anti-inflammatory enamandla, imisebenzi elwa namagciwane, i-antibacterial kanye nokunciphisa umfutho wegazi.

Igama Lomkhiqizo:Ukukhishwa kweqabunga lecelery i-Apigenin 98%

Igama lesiLatini: Apium graveolens L.

Inombolo ye-CAS: 520-36-5

Ingxenye Yesitshalo Esetshenzisiwe:Leaf

Isithako:Apigenin

I-Assay:Apigenin 98.0% nge-HPLC

Umbala:Impushana ensundu kuya kokuphuzi enephunga elibonakalayo kanye nokunambitha

Isimo se-GMO:GMO Mahhala

Ukupakisha: ku-25kgs fiber drums

Isitoreji: Gcina isitsha singavulwa endaweni epholile, eyomile, gwema ukukhanya okuqinile

Impilo Yeshelufu: Izinyanga ezingama-24 kusukela ngosuku lokukhiqiza

Umphumela we-Anti-tumor

I-Apigenin idlala indima ebalulekile ekuvimbeleni umdlavuza ngokufaka i-apoptosis emigqeni yamaseli ehlukahlukene.

Umdlavuza wesibeletho:

Olunye ucwaningo lwatholakala ukuthi i-apigenin ingavimbela ukukhula, ukwanda, nokudluliselwa kwe-ca-ov3 (iseli lomdlavuza we-ovarian womuntu);idala i-apoptosis ye-ca-ov3 ngokugcina amangqamuzana omdlavuza emile esigabeni se-G2/M.Umphumela uhlobene nesikhathi nomthamo.

Umdlavuza we-pancreatic:

I-Apigenin ingavimbela ukwanda kwamaseli omdlavuza we-pancreatic.I-Apigenin ilambisa isimila ngokunciphisa umthombo weglucose, okuwukudla okuhlala kukho amangqamuzana omdlavuza.Ngaphandle kwalokho, i-Apigenin ingathuthukisa ukusebenza kwe-chemotherapy drug- gemcitabine.

I-Chemo-sensitization

Kutholwe ukuthi i-apigenin kokuqukethwe okuphansi inomphumela ophansi we-cytotoxic futhi ayikwazanga ukunxenxa amaseli e-acute myeloid leukemia (hl-60) ku-apoptosis ngempumelelo.Kodwa-ke, i-apigenin ingathuthukisa umphumela we-inhibitory we-cisplatin (DDP) ekwandeni kwamaseli e-hl-60 ngenkathi ihlanganiswa nokugxila okuhlukile kwe-DDP.Ngakho i-Apigenin ingase ibe nomphumela wokuzwela ngamakhemikhali ku-hl-60;Ukugxila okuphansi kwe-apigenin nakho kunganciphisa ukumelana kwamaseli e-hl-60 ku-apoptosis eyenziwe ngamakhemikhali, okungenzeka ihlotshaniswe nokulawulwa phansi kwe-NF-κB ne-BCL-2.(I-NF-KB iwuhlobo lwe-protein complex elawula ukubhalwa kwe-DNA, ukukhiqizwa kwama-cytokines nokusinda kweseli; i-BCL-2 ifakwe ikhodi emzimbeni ngofuzo lwe-BCL2, iyilungu lokuqala lomndeni wamaprotheni alawulayo we-BCL-2 ingalawula ukufa kwamaseli)

Ukuvikelwa kwesibindi

I-Apigenin inganciphisa ukulimala kwesibindi okudalwe i-ischemia-reperfusion ngokusebenzisa i-lipid peroxidation ephikisayo kanye nokukhipha ama-radicals mahhala.

I-Apigenin inganciphisa ukulimala kwesibindi okubangelwa ukucindezeleka kwe-oxidative ngenxa yemisebenzi yayo enamandla ye-antioxidant kanye ne-anti-inflammatory.

Ukuhlolwa kwe-Pharmacological kuye kwafakazela ukuthi i-apigenin inomphumela obonakalayo wokuvikela ekulimazeni kwesibindi / i-hepatocyte okubangelwa utshwala, futhi indlela yayo eyinhloko ihlobene nokuvinjelwa kwenkulumo ye-CYP2E1 esibindini/hepatocyte.

Vimbela i-osteoporosis

I-Apigenin ivimbela i-osteoblastogenesis, i-osteoclastogenesis, futhi ivimbela ukulahleka kwamathambo.

I-Apigenin ivikela izicubu zethambo ngokunciphisa ukulahleka kwamathambo emzimbeni.

Ezinye izifundo ezihlobene ne-MC3T3-E1, i-osteoblast precursor cell line etholakala ku-Mus musculus (igundane) calvaria, ithole ukuthi i-apigenin ingavimbela i-TNF-α, IFN-γ, bese idala ukukhishwa kwama-cytokines amaningana akhuthaza ukwakheka kwe-osteoclast.

I-Apigenin iphinde yavimbela ukuhlukaniswa kwamaseli we-3T3-L1 adipose precursor ku-adipocyte ngokuqinile, ngakho-ke ivimbele ukuhlukaniswa kwe-adipocyte inhibition-induced adipocyte differentiation-induced IL-6, MCP-1, umkhiqizo we-lectin.

I-Apigenin ivimbela ukuhlukaniswa kwama-osteoclasts kusuka kumigqa yamaseli angu-RAW264.7 bese ivimbela ukwakheka kwama-osteoclast ane-multinucleated.Ingase futhi ibangele i-osteoclast apoptosis futhi ivimbele ukubuyiswa kwamathambo.

Umsebenzi wokulwa nokuvuvukala kanye ne-antioxidant

I-Apigenin ivimbela inqubo yokuvuvukala, inyusa amazinga e-IL-10 futhi ijwayele imingcele ye-oxidative stress.

I-Apigenin ivimbela ukuvuvukala kwama-cytokines futhi ikhuthaza ukukhiqizwa kwe-cytokine elwa nokuvuvukala.

Ezinye izincwadi ziphakamisa ukuthi i-apigenin inciphisa ukuvuvukala kwezicubu okubangelwa ukucindezeleka kwe-oxidative ezicutshini ngokushintsha izimpawu zokucindezeleka ze-oxidative, ama-interleukin, izimpawu ze-enzyme yegazi, nokuvezwa kwamanye ama-enzyme amaningana ahlobene.

Ukulawulwa kwe-endocrine

I-Apigenin ingalawula ushukela osegazini, yelaphe ukwehluleka kwe-thyroid futhi ilawule i-lipid peroxidation. Kwatholakala ukuthi i-apigenin ingakhuphula amazinga e-insulini ne-thyroxine ezilwaneni ezinesifo sikashukela, futhi yehlise ukugcwala kushukela egazini kanye nomsebenzi we-glucose-6-phosphorylase (G- 6-Pase).

I-Apigenin iguqule imiphumela yokwanda kwe-serum cholesterol, ukwanda kwe-lipid peroxidation yesibindi (LPO) kanye nokuncipha kwemisebenzi yama-antioxidants njenge-catalase (CAT) ne-superoxide dismutase (SOD) ezilwaneni ezibangelwa i-alloxan.

Ezilwaneni ezinoshukela wegazi ojwayelekile, i-apigenin nayo inganciphisa i-serum cholesterol kanye ne-lipid peroxidation yesibindi, futhi ikhulise umsebenzi wama-antioxidants kumaseli.

Izici ze-Pharmacological ze-apigenin

I-Apigenin inanyathiselwe ukubaluleka okukhulu eminyakeni yamuva nje, njengomgqugquzeli wezempilo ozuzisayo ngenxa yobuthi bayo obuphansi bangaphakathi kanye nemiphumela yayo yezempilo kumaseli omdlavuza avamile uma kuqhathaniswa namanye ama-flavonoid ahlobene nesakhiwo.Kunobufakazi obuningi bocwaningo obubonise ukuthi i-apigenin inamandla amakhulu okwelapha izifo eziningi

Umsebenzi:

-Avimbe ukukhula kwamangqamuzana omdlavuza.

-Yehlisa umfutho wegazi

-Ivikela uhlelo lwenhliziyo nemithambo yegazi

-Siza ukulala, ukuthulisa izinzwa, ukuqeda ukucasuka

-Melana nokuvuvukala

- Vimbela i-osteoporosis

- Umphumela we-diuretic.

- Thinta ukuhlangana kweplatelet.

Isicelo:

-Insimu yezokwelapha, inkambu yokunakekelwa kwezempilo