I-Beta-nicotinamide Mononucleotide (NMN), umkhiqizo wokusabela kwe-NAMPT kanye nokhiye we-NAD+ omaphakathi, ithuthukisa ukungabekezelelani kwe-glucose ngokubuyisela amazinga e-NAD+ kumagundane e-T2D enziwe yi-HFD.I-NMN iphinde ithuthukise ukuzwela kwe-insulin yesibindi futhi ibuyisele ukubonakaliswa kofuzo okuhlobene nengcindezi ye-oxidative, impendulo yokuvuvukala, nesigqi se-circadian, ngokwengxenye ngokusebenzisa i-SIRT1.I-NMN isetshenziselwa ukutadisha ama-motifs abophayo ngaphakathi kwama-aptamers e-RNA kanye nezinqubo zokuvula i-ribozyme ezibandakanya izingcezu ze-RNA ezicushiwe ze-β-nicotinamide mononucleotide (Beta-NMN).
I-Nicotinamide mononucleotide (“NMN” kanye “ne-β-NMN”) iyinucleotide etholakala ku-ribose ne-nicotinamide.I-Niacinamide (i-nicotinamide,) iwuhlobo lukavithamini B3 (niacin.) Njengesandulela samakhemikhali ezinto eziphilayo we-NAD+, ingase ibe usizo ekuvimbeleni i-pellagra.
Ifomu layo elingagxiliwe, i-niacin, litholakala emithonjeni ehlukahlukene yokudla okunomsoco: Amantongomane, Amakhowe (portobello, eyosiwe), Ukwatapheya, Uphizi Oluhlaza (fresh), kanye nezinhlanzi ezithile nenyama yezilwane.
Ocwaningweni [kumagundane], i-NMN ibonise ukubuyisela emuva ukungasebenzi kahle kwe-arterial okuhlobene neminyaka ngokunciphisa ingcindezi ye-oxidative.
Igama: Beta-I-Nicotinamide Mononucleotide
I-CAS ＃: 1094-61-7
Igama lomkhiqizo: Beta-Nicotinamide Mononucleotide;NMN
Elinye igama:β-D-NMN;BETA-NMN;beta-D-NMN;NMN zwitterion;Nicotinamide Ribotide;Nicotinamide nucleotide;Nicotimide mononucleotide;Nicotinamide mononuclotide
CAS:1094-61-7
Ifomula yemolekyuli: C11H15N2O8P
Isisindo se-molecule: 334.22
Ubumsulwa: 98%
Izinga Lokushisa Lesitoreji: 2-8°C
Ukubukeka: Impushana emhlophe
Sebenzisa: anti-ukuguga
Umsebenzi:
I-1.I-Nicotinamide mononucleotide emangqamuzaneni omuntu idlala indima ebalulekile ekukhiqizeni amandla, ihileleke ku-NAD ye-intracellular (nicotinamide adenine dinucleotide, ukuguqulwa kwe-cell energy ebalulekile i-coenzyme) synthesis, esetshenziselwa ukulwa nokuguga, ukuwa ushukela wegazi neminye imikhiqizo yokunakekelwa kwezempilo.
2. I-Nicotinamide Mononucleotide iyivithamini encibilika emanzini, Umkhiqizo uyimpushana emhlophe eyicrystalline, ayinaphunga noma cishe ayinaphunga, ukunambitheka okubabayo, kuncibilika ngokukhululekile emanzini noma ethanol, incibilika ku-glycerin.
I-3.I-Nicotinamide Mononucleotide kulula ukumunca ngomlomo, futhi ingasatshalaliswa kabanzi emzimbeni, ama-metabolites amaningi noma i-prototype ikhipha ngokushesha emchameni.INicotinamide iyingxenye ye-coenzyme I kanye ne-coenzyme II, idlala indima yokulethwa kwe-hydrogen kuchungechunge lokuphefumula lwe-oxidation, ingakhuthaza izinqubo ze-biological oxidation kanye ne-tissue metabolism, igcine izicubu ezijwayelekile (ikakhulukazi isikhumba, umgudu wokugaya ukudla kanye nesimiso sezinzwa) ubuqotho bunendima ebalulekile. .
Ngaphezu kwalokho, i-nicotinamide inokuvimbela nokwelashwa kwe-heart block, umsebenzi we-sinus node kanye ne-anti-fast arrhythmias yokuhlola, i-nicotinamide ingathuthukisa kakhulu izinga lokushaya kwenhliziyo kanye ne-atrioventricular block ebangelwa i-verapamil.
