I-Sialic Acid Powder

I-Sialic acid (SA), ngokwesayensi eyaziwa ngokuthi “i-N-acetylneuraminic acid,” icarbohydrates eyenzeka ngokwemvelo.Ekuqaleni yayihlukanisiwe ne-submandibular gland mucin, yingakho igama.I-Sialic acid ivame ukuba khona ngesimo sama-oligosaccharides, ama-glycolipids noma ama-glycoprotein.Emzimbeni womuntu, ubuchopho bunokuqukethwe okuphezulu kwe-sialic acid.Okuqukethwe kwe-asilic acid ku-grey matter izikhathi ezingu-15 kwezitho zangaphakathi ezifana nesibindi namaphaphu.Umthombo wokudla oyinhloko we-sialic acid ubisi lwebele, olutholakala nobisi, amaqanda kanye noshizi.

Kwezokwelapha, ama-glycolipids aqukethe i-sialic acid abizwa ngokuthi ama-gangliosides, adlala indima ebaluleke kakhulu ekukhiqizeni nasekuthuthukisweni kobuchopho nesimiso sezinzwa.Ngesikhathi esifanayo, izifundo zezilwane ziye zabonisa ukuthi ukuncishiswa kwamazinga e-ganglioside kuhlotshaniswa nokungondleki kwasekuqaleni kanye nekhono lokufunda elincishisiwe, kuyilapho ukufakwa nge-asilic acid kungathuthukisa ukuziphatha kokufunda kwezilwane.Ukutholakala okwanele kweasidi ye-sialic kungase kubaluleke kakhulu ekukhuleni okuvamile kokusebenza kobuchopho ezinganeni ezinesisindo esiphansi sokuzalwa.Ngemva kokuzalwa kwengane, i-asilic acid obisini lwebele ibalulekile ukuze kuqinisekiswe ukukhula kwayo okuvamile.Uphenyo lubonise ukuthi amazinga e-sialic acid komama ngemva kokubeletha ayehla ngokuhamba kwesikhathi.Ngakho-ke, ukuphuza okuqhubekayo kwenani elanele le-asilic acid ngesikhathi sokukhulelwa nangemva kokukhulelwa kungasiza ekugcineni amazinga e-asilic acid emzimbeni.Ngaphezu kwalokho, okuqukethwe kwe-asilic acid nakho kuhlotshaniswa kakhulu nokuqukethwe kwe-DHA, okuphakamisa ukuthi kungenzeka kakhulu ukuthi ihlotshaniswe nesakhiwo sobuchopho kanye nokuthuthukiswa kokusebenza kobuchopho ezinsaneni, kokubili okungase kube nenzuzo ekuthuthukiseni ubuchopho bokuqala.

Ucwaningo luye lwabonisa ukuthi isikhathi segolide sokuthuthukiswa kobuchopho bomuntu siphakathi kweminyaka engu-2 no-2 ubudala.Lesi sigaba yisikhathi esibalulekile sokulungiswa kwenombolo yeseli yobuchopho, ukukhuphuka kwevolumu, ukuphelela kokusebenza, nokwakheka kwenethiwekhi ye-neural.Ngakho-ke, omama abahlakaniphile bazonaka ngokwemvelo ekuthathweni kwenani elanele le-asilic acid ngesikhathi sokukhulelwa.Ngemva kokuzalwa kwengane, ubisi lwebele luyindlela ephumelelayo yokwengeza i-asilic acid enganeni, ngoba cishe u-0.3-1.5 mg we-asilic acid ngemililitha yobisi lwebele.Eqinisweni, zonke izilwane ezincelisayo, kuhlanganise nabantu, ziyakwazi ukuhlanganisa i-asilic acid esibindini ngokwazo.Kodwa-ke, ukukhula kwesibindi kwezingane ezisanda kuzalwa akukakavuthwa, futhi isidingo sokukhula ngokushesha nokuthuthukiswa kobuchopho singanciphisa ukuhlanganiswa kwe-sialic acid, ikakhulukazi ezinganeni ezizalwa ngaphambi kwesikhathi.Ngakho-ke, i-asilic acid obisini lwebele ibalulekile ekuqinisekiseni ukukhula okuvamile nokuthuthukiswa kwengane.
Abacwaningi base-Australia bathole ukuthi izinsana ezincela ibele zinezinga eliphakeme le-sialic acid ku-frontal cortex kunezinsana ezinceliswa ifomula.Lokhu kungase kukhuthaze ukwakheka kwama-synapses, kusize inkumbulo yengane yakhe isisekelo sesakhiwo esizinzile, futhi kuqinise ukuthuthukiswa kwesimiso sezinzwa.

Iyini i-Sialic acid

I-Sialic Acidiqoqo lokuphuma kwe-neuraminic acid (i-N- noma i-O-substituted derivatives neuraminic acid).Ngokuvamile ngesimo sama-oligosaccharides, ama-glycolipids noma ama-glycoprotein.

I-Sialic Acidfuthi igama lelungu elivame kakhulu laleli qembu – i-N-acetylneuraminic acid (Neu5Ac noma i-NANA).

Umndeni we-asilic acid

Sekwaziwa ngamalungu acishe abe ngu-50, konke okuphuma ku-9-carbon sugar neuraminic acid ekhokhiswe kabi.

I-N-acetylneuraminic acid (Neu5Ac), i-N-glycolylneuraminic

i-asidi (Neu5Gc) ne-deaminoneuraminic acid (KDN) iwumonoma wayo oyinhloko.

I-N-acetylneuraminic acid iwukuphela kohlobo lwe-Sialic Acid emzimbeni wethu.

I-Sialic Acid kanye nesidleke seNyoni

Ngenxa yokuthi i-Sialic acid inothile esidlekeni senyoni, ibizwa nangokuthi i-bird's nest acid, okuyinkomba ebalulekile yokuhlelwa kwesidleke sezinyoni.

I-Sialic Acid iyizithako eziyinhloko zokudla esidlekeni seNyoni, cishe u-3% -15% ngesisindo.

Phakathi kwakho konke ukudla okwaziwayo, isidleke se-Bird siqukethe inani eliphakeme kakhulu le-Sialid acid, cishe izikhathi ezingama-50 ngaphezu kokunye ukudla.

1g Isidleke senyoni silingana namaqanda angama-40 uma sithola inani elifanayo le-Sialic Acid.

Imithombo yokudla ye-Sialic Acid

Ngokuvamile, izitshalo azinayo i-asilic acid.Ukunikezwa okuhamba phambili kwe-Sialic acid ubisi lomuntu, inyama, iqanda, noshizi.

Okuqukethwe kwengqikithi ye-asilic acid ekudleni okuvamile (µg/g noma µg/ml).

Siyabona ukuthi i-Sialic acid ebisini Lomuntu iphezulu, okuyisithako esiyinhloko ekukhuleni kobuchopho bomntwana.

Kodwa okuqukethwe kwe-Sialic Acid kuhlukile eZikhathini ezahlukene Ubisi lomuntu

I-colostrum yobisi lwebele 1300 +/- 322 mg/l

Ezinsukwini eziyi-10 kamuva 983 +/- 455 mg/l

Impushana yobisi lwengane ngaphambi kwesikhathi 197 +/- 31 mg/l

Amafomula obisi aguquliwe 190 +/- 31 mg/l

Amafomula obisi aguqulelwe ngokwengxenye 100 +/- 33 mg/l

Amafomula obisi okulandelela 100 +/- 33 mg/l

Amafomula obisi asekelwe ku-soy 34 +/- 9 mg/l

Uma kuqhathaniswa nobisi lwebele, impushana yobisi lwezingane iqukethe cishe u-20% we-Sialic acid obisini Lomuntu, kuyilapho ingane ingathola kuphela u-25% we-Sialic acid obisini Lwebele.

Enganeni Engakafiki Isikhathi, i-Sialic acid ibaluleke kakhulu kunengane enempilo ekuthuthukisweni kobuchopho.

I-Sialic Acid Study ku-Milk powder

“Imiphumela iveze ukuthi okuqukethwe yi-sialic acid yobuchopho kudlala indima ebalulekile ekunqumeni ukuziphatha.Elinye iqembu libone ukufunda okuthuthukile ngokwelashwa kwamahhala kwe-sialic acid kumagundane.”

Ukubuyekezwa kwe-CAB: Imibono Kwezolimo, Isayensi Yezilwane, Ukudla Okunempilo, kanye Nezemvelo

Izinsiza 2006 1, No. 018, Ingabe i-asilic acid obisini wukudla kwengqondo?, Bing Wang

"Isiphetho sithi i-Higher brain ganglioside kanye ne-glycoprotein sialic acid egxile ezinsaneni ezifunzwa ngobisi lwabantu kuphakamisa ukwanda kwe-synaptogenesis kanye nokwehluka kwe-neurodevelopment."

U-Am J Clin Nutr 2003;78:1024–9.Ishicilelwe e-USA.© 2003 American Society for Clinical Nutrition，Brain ganglioside, ne-glycoprotein sialic acid ekunceliseni ibele uma kuqhathaniswa nezinsana ezinceliswa ubisi oluyimpuphu, u-Bing Wang

I-Neural cell membranes iqukethe i-sialic acid ephindwe izikhathi ezingu-20 kunezinye izinhlobo zolwelwesi, okubonisa ukuthi i-sialic acid inendima ecacile ekwakhiweni kwemizwa.

I-European Journal of Clinical Nutrition, (2003) 57, 1351-1369, Indima namandla e-asilic acid ekudleni komuntu, i-Bing Wang

Isicelo se-N-Acetylneuraminic acid

I-Milk Powder

Njengamanje, impushana yobisi yomama Abancelisa ibele iye yanda, Impushana Yobisi Lwezingane, kanye Nezithako Zokudla okunomsoco ziqukethe i-Sialic Acid Emakethe.

Komama Abancelisa Ibele

Nge-Baby Milk powder 0-12 izinyanga

Okomkhiqizo wokunakekelwa kwezempilo

OkweSiphuzo

Njengoba i-Sialic acid inekhono elihle lokuncibilika emanzini, izinkampani eziningi zizama ukuthuthukisa iziphuzo ze-Sialic acid zempilo yobuchopho noma zengeze emikhiqizweni yobisi.

Ukuphepha kwe-N-Acetylneuraminic acid

I-N-Acetylneuraminic acid iphephe kakhulu.Njengamanje, azikho izindaba ezimbi ezibikiwe nge-Sialic acid.

Ohulumeni base-USA, China, kanye ne-EU bagunyaza i-Sialic acid ukuthi isetshenziswe emikhiqizweni yokunakekelwa kwe-Food and Health.

USA

Ngo-2015, i-N-Acetyl-D-neuraminic acid (i-Sialic acid) yanqunywa njenge-Generally Recognized as Safe (GRAS)

China

Ngo-2017, uHulumeni wase-China wagunyaza i-N-Acetylneuraminic acid njengesithako Esisha Sokudla Kwensiza.

EU

Ukuphepha kwe-synthetic N-acetyl-d-neuraminic acid njengokudla kwenoveli ngaphansi koMthethonqubo (EC) No 258/97

Ngomhla ziyi-16 kuMfumfu wezi-2015, igama lezintandane (EU/3/12/972) lanikezwa yiKhomishini YaseYurophu ku-Ultragenyx UK Limited, e-United Kingdom, nge-asilic acid (eyaziwa nangokuthi i-aceneuramic acid) yokwelapha i-GNE myopathy.

Umbono Wesayensi mayelana nokuqinisekiswa kwezimangalo zezempilo ezihlobene ne-sialic acid nokufunda nenkumbulo (ID 1594) ngokususelwe ku-Athikili 13(1) Yomthethonqubo (EC) No 1924/2006

Umthamo

I-CFDA iphakamisa i-500mg / ngosuku

Ukudla okunoveli kuphakamisa u-55mg/ngosuku Olusana kanye no-220mg/ngosuku kwabesifazane Abancane nabaneminyaka ephakathi

Umsebenzi we-N-acetylneuraminic acid

Inkumbulo kanye nokuthuthukiswa kobuhlakani

Ngokusebenzelana nolwelwesi lwamangqamuzana obuchopho nama-synapses, i-Sialic acid inyusa izinga lokuphendula lama-synapse kumaseli ezinzwa zobuchopho, ngaleyo ndlela ikhuthaze ukuthuthukiswa kwenkumbulo nobuhlakani.

Ososayensi baseNew Zealand benze uchungechunge lokuhlola ukuze baqinisekise indima ebalulekile ye-acid yenyoni ekukhuleni kwengqondo yezingane.Ekugcineni, abacwaningi baphetha ngokuthi ukufaka i-asidi yenyoni ezinsaneni kungase kwandise ukugcwala kwe-asidi yenyoni ebuchosheni, ngaleyo ndlela kuthuthukise ikhono lobuchopho lokufunda.

Thuthukisa amandla okumunca amathumbu

Ngokusho kwesimo esilula somzimba wobulili obuhlukile, amaminerali anecala elihle namanye amavithamini angena emathunjini ahlanganiswa kalula ne-acid yenyoni enecala elibi esidlekeni, ngakho ukumuncwa kwamathumbu emathunjini namaminerali.Ikhono lithuthukisiwe kuyo.

Khuthaza ukukhishwa kwe-antibacterial emathunjini

I-Sialic Acid kuphrotheni ye-membrane yeseli idlala indima ebalulekile ekuthuthukiseni ikhono lokuqashelwa kwamaseli, ukukhipha ubuthi bobuthi bekholera, ukuvimbela ukutheleleka nge-pathological Escherichia coli, kanye nokulawulwa kwesigamu sempilo yamaprotheni egazi.

Ukuphila isikhathi eside

I-Sialic acid inomphumela wokuvikela nokuzinza kumaseli, futhi ukuntuleka kwe-asilic acid kungaholela ekwehleni kwempilo yamangqamuzana egazi kanye nokwehla kwe-glycoprotein metabolism.

Yenza umuthi omusha we-Sialic Acid

Ososayensi bazama ukwelapha izifo zesisu ngemithi ye-asilic acid anti-adhesion.Imithi ye-Sialic acid anti-adhesive ingakwazi ukwelapha i-Helicobacter pylori ukwelapha izilonda zesisu kanye nezilonda ze-duodenal.

I-Sialic acid iyi-glycoprotein.Inquma ukuqashelwa okufanayo nokubophezela kwamaseli futhi inemiphumela yokulwa nokuvuvukala efana ne-aspirin.

I-Sialic acid iyisidakamizwa sezifo ezimaphakathi noma ezisezingeni eliphezulu zemizwa kanye nezifo eziqeda amandla;I-asilic acid nayo iyi-expectorant yokukhwehlela.

I-Sialic acid njengempahla eluhlaza ingathuthukisa uchungechunge lwezidakamizwa ezibalulekile zikashukela, i-anti-virus, i-anti-tumor, i-anti-inflammatory, kanye nokwelashwa kokuwohloka komqondo obuthakathaka kunemiphumela evelele.

Inqubo yokukhiqiza i-Sialic Acid

Izinto zokusetshenziswa eziqala ngokuyinhloko i-glucose, utshwala obuwummbila, i-glycerinum, ne-magnesium sulfate.Futhi sisebenzisa ubuchwepheshe obuvutshiwe.Phakathi nalolu hlelo, sisebenzisa indlela yokuvala inzalo ukuze sigcine izinto ezisetshenziswayo zihlanzekile.Khona-ke nge-hydrolysis, ukugxila, ukomisa, nokuphihliza.Ngemuva kwazo zonke izinqubo, sithola umkhiqizo wokugcina.Futhi i-QC yethu izosebenzisa i-HPLC ukuhlola ikhwalithi yezinto ezibonakalayo kuwo wonke amaqoqo ngaphambi kokuba siyilethe kumakhasimende.

Igama Lomkhiqizo: I-Sialic acid ;I-N-Acetylneuraminic acid

Elinye Igama:5-Acetamido-3,5-dideoxy-D-glycero-D-galactonulosonic acid o-Sialic acid Galactononulosonic acid Lactamineic acid NANA N-Acetylsialic acid

Umsuka: Isidleke senyoni edliwayo
Ukucaciswa: 20%–98%
Ukubukeka: impushana emhlophe emhlophe
INOMBOLO YECAS: 131-48-6
MW: 309.27
MF: C11H19NO9

Indawo Yomsuka: China

Isitoreji: Gcina endaweni epholile neyomile, gwema ukukhanya nokushisa okuqondile.
Ukuba semthethweni: Iminyaka emibili uma igcinwe kahle.

UMSEBENZI:

1. Umsebenzi we-Anti-virus.
2. Umsebenzi wokulwa nomdlavuza.
3. Umsebenzi wokulwa nokuvuvukala.
4. Umsebenzi wokuzivikela ngokumelene ne-bacteriological infectiong.
5. Ukulawula ikhono lamasosha omzimba.
6. Ikhono lokuvimbela ngokumelene ne-pigmentation.
7. Ukuguqulwa kwesignali kumaseli wezinzwa.
8. Bamba iqhaza elibalulekile ekukhuleni kobuchopho nokufunda.
9. Njengesandulela sokwenziwa kwemithi eminingi yemithi.