inoa huahana:Agomelatine

Inoa ʻē aʻe:N-[2-(7-Methoxy-1-naphthyl)ethyl]acetamide;N-[2-(7methoxynaphthalen-1-yl)ethyl]acetamide

ʻAʻohe CAS:138112-76-2

Nā kikoʻī: 99.0%

Ka waihoʻoluʻu: ʻO ka pauka keʻokeʻo me ka ʻala a me ka ʻono

Kūlana GMO: ʻAʻole GMO

Hoʻopili: ma 25kgs fiber drums

Ka mālama ʻana: E mālama i ka pahu i wehe ʻole ʻia ma kahi maloʻo a maloʻo, e haʻalele i ka mālamalama ikaika

Ola Ola: 24 mahina mai ka lā i hana ʻia

Agomelatinehe ʻano antidepressant hou. ʻO kāna hana o ka hana e haki i ka ʻōnaehana transmitter monoamine maʻamau. ʻO Agomelatine he agonist melatoninergic a me ka mea kū'ē koho o 5-HT2C receptors, a ua hōʻike ʻia ʻo ia e hana i nā ʻano holoholona o ke kaumaha. Ua hōʻike ʻo Agomelatine (S20098) i nā waiwai pKi o 6.4 a me 6.2 ma ka ʻōiwi (porcine) a me ka cloned, kanaka (h) 5-hydroxytryptamine (5-HT) 2C receptors, kēlā me kēia.

ʻO Agomelatine kekahi ʻano o ka pauka keʻokeʻo keʻokeʻo keʻokeʻo a i ʻole ka paʻa keʻokeʻo. ʻO ka inoa IUPAC o kēia kemika ʻo N-[2-(7-methoxynaphthalen-1-yl)ethyl]acetamide. No kēia mea kemika i nā Aromatics Compounds; Aromatics; Neurochemicals; APIS. Pono e mālama ʻia ma kahi -20 ° C i ka pahu hau.

 
Ma ke ʻano he Pharmaceutical Intermediates, hoʻohana ʻia ʻo Agomelatine i ka mālama ʻana i ka maʻi depressive nui, ka maʻi naʻau. Hoʻohana ʻia ʻo Agomelatine i ka mālama ʻana i ka maʻi depressive nui, ka maʻi naʻau. ʻO ka lāʻau lapaʻau no ka ʻōnaehana Nervous. Antidepressant, anxiolytic, hoʻoponopono i ke kani o ka hiamoe a me ka hoʻoponopono ʻana i ka uaki ola. ʻO Agomelatine kahi agonist melatoninergic a me ka antagonist koho o 5-ht2c receptors. ʻO Agomelatine kahi lāʻau antidepressant. Hoʻokaʻawale ʻia ʻo ia ma ke ʻano he norepinephrine-dopamine disinhibitor (NDDI) ma muli o kāna antagonism o ka 5-HT2C receptor. ʻO Agomelatine kekahi agonist ikaika i nā mea loaʻa melatonin e hoʻolilo iā ia i ka antidepressant melatonergic mua.

.Agomelatine pili pili loa i ka melatonin. ʻO Agomelatine kahi agonist ikaika ma nā melatonin receptors a me kahi antagonist ma serotonin-2C (5-HT2C) receptors, i hoʻāʻo ʻia i kahi ʻano holoholona o ke kaumaha.

ʻO Agomelatine kahi antidepressant i hoʻohana ʻia e mālama i ke kaumaha.

Maikaʻi ka lolo i ka hōʻoia ʻana ua lawa mākou i nā kemika e pono ai mākou e hana pono. Akā, hiki i ke kaumaha ke hoʻopilikia i kekahi mau kemika lolo.

ʻO kēia mau kemika he noradrenaline, dopamine a me serotonin; hoʻemi ke kaumaha i nā pae o kēia mau mea hoʻouna lolo. Hoʻopilikia pū ke kaumaha i kahi kemika i kapa ʻia he melatonin. Hoʻopili ʻia ka melatonin i hoʻemi ʻia i nā haunaele i kā mākou moe.

ʻO Agomelatine ka antidepressant mua e hoʻonui pololei i ka hana melatonin. Hana ia e like me ka melatonin ma nā wahi i hoʻopaʻa ʻia kahi e hana ai ka melatonin. (Ua ʻike ʻia kēia mau mea loaʻa melatonin). Ma ka hoʻonui ʻana i ka hana melatonin, hoʻonui pololei ʻo agomelatine i ka hana o ka noradrenaline a me ka dopamine.

Ua hoʻokuʻu mua ʻia ʻo Agomelatine ma ʻEulopa ma 2009 a ua ʻae ʻia i kēia manawa no ka hoʻohana ʻana ma nā ʻāina ʻoi aku ma mua o 70. ʻAʻole like me nā antidepressants kuʻuna, hana ʻo agomelatine ma ka huli ʻana i ka melatonin a me ka serotonin receptors i ka lolo. Ma ka hana ʻana ma ke ʻano he agonist i ka melatonin receptors, kōkua ʻo agomelatine i ka hoʻomaʻamaʻa ʻana i nā hiʻohiʻona hiamoe i hoʻopilikia pinepine ʻia me ke kaumaha. ʻAʻole kōkua kēia ʻano hana i ka hoʻomaikaʻi ʻana i ka maikaʻi o ka hiamoe akā kōkua pū kekahi i ka hoʻihoʻi ʻana i nā mele circadian kūlohelohe. Eia kekahi, hana ʻo agomelatine ma ke ʻano he antagonist ma kekahi mau mea loaʻa serotonin (5-HT2C receptors). ʻO kēia hana ʻelua ʻokoʻa e hoʻonui i ka loaʻa o ke serotonin i loko o ka lolo, kahi neurotransmitter kuleana no ka hoʻoponopono ʻana i ke ʻano. Ma ka hoʻoponopono ʻana i nā pae serotonin, hiki i ka agomelatine ke hana ma ke ʻano he antidepressant maikaʻi, hoʻomaha i nā hōʻailona e like me ke kaumaha, ka nalowale o ka hoihoi, nā manaʻo o ka hewa a i ʻole ka waiwai ʻole. Eia kekahi, hiki i ka agomelatine ke hāʻawi i nā pono ʻē aʻe. Hōʻike ka noiʻi hiki ke kōkua i ka hoʻomaikaʻi ʻana i ka hana noʻonoʻo.

Hana:

Hiki iā Agomelatine ke kōkua i ka hoʻoponopono ʻana i kou 'clock clock' (circadian rhythm) me nā pōmaikaʻi maikaʻi ma ke ʻano a me ka hiamoe hiamoe. ʻOkoʻa nā hōʻailona o ke kaumaha mai kekahi kanaka a i kekahi, akā ʻo ka mea maʻamau e komo pū me ke kaumaha mau, ka nalowale o ka hoihoi i nā hana punahele, nā manaʻo waiwai ʻole, nā pilikia hiamoe, ka manaʻo o ka lohi ʻana, nā manaʻo hopohopo a i ʻole nā ​​loli i ka ʻai a me ke kaumaha. ʻO nā hoʻololi i kāu hiamoe i kēlā me kēia lā a me nā ʻano ʻai ʻai he mau hiʻohiʻona o nā haʻalulu o kou uaki kino e kū maʻamau i ke kaumaha.