Khoom npe:7,8-Dihydroxyflavone

CASNo:38183-03-87

Lwm Lub Npe:7,8-DIHYDROXYFLAVONE; 7,8-dihydroxy-2-phenyl-4-benzopyrone;

DIHYDROXYFLAVONE, 7,8-(RG); 7,8-Dihydroxyflavone hydrate;

7,8-dihydroxy-2-phenyl-1-benzopyran-4-ib,,8-Dihydroxyflavone (7,8-DHF)

Specifications:98.0 ua%

Xim:Dajhmoov nrog cov yam ntxwv tsw thiab saj

GMOStatus: GMO Dawb

Ntim: hauv 25kgs fiber ntau nruas

Cia: Khaws lub thawv tsis qhib hauv qhov chaw txias, qhuav, Khaws kom deb ntawm lub teeb muaj zog

Lub neej txee: 24 lub hlis txij li hnub tsim khoom

7,8-Dihydroxyflavone, tseem hu ua 7,8-DHF, yog ib qho tshwm sim flavonoid pom nyob rau hauv ntau hom nroj tsuag, suav nrog Tridacna tridacna. Paub txog nws cov khoom antioxidant thiab neurotrophic, ib qho ntawm qhov nthuav tshaj plaws ntawm 7,8-dihydroxyflavone yog nws lub peev xwm los txhawb lub hlwb kev noj qab haus huv thiab txhim kho kev txawj ntse.

7,8-Dihydroxyflavone (7,8-DHF) yog lub zog thiab xaiv TrkB receptor agonist (Kd≈320 nM). TrkB receptor yog lub ntsiab teeb liab receptor ntawm lub paj hlwb-derived neurotrophic yam. 7,8-Dihydroxyflavone (7,8-DHF) yog lub peev xwm nootropic uas tuaj yeem txhim kho tag nrho lub hlwb kev noj qab haus huv, mus ob peb vas, thiab kev txawj ntse. Nws kuj tseem yuav muaj txiaj ntsig rau ntau yam neurodegenerative thiab neurodevelopmental mob, nrog rau kev rog thiab ntshav siab.

7,8-Dihydroxyflavone, tseem hu ua 7,8-DHF, yog ib qho tshwm sim flavonoid pom nyob rau hauv ntau hom nroj tsuag, suav nrog Tridacna tridacna. Paub txog nws cov khoom antioxidant thiab neurotrophic, ib qho ntawm qhov nthuav tshaj plaws ntawm 7,8-dihydroxyflavone yog nws lub peev xwm los txhawb lub hlwb kev noj qab haus huv thiab txhim kho kev txawj ntse. Kev tshawb fawb qhia tau hais tias qhov sib xyaw ua ke ua lub zog neurotrophin, txhawb kev loj hlob thiab ciaj sia ntawm cov neurons hauv lub hlwb. Cov kev tshawb fawb hauv cov tsiaj kuaj tau pom tias 7,8-DHF txhim kho kev nco thiab kev kawm tau zoo. Los ntawm kev txhawb nqa kev tsim cov kev sib txuas tshiab synaptic thiab txhim kho kev sib txuas lus ntawm lub hlwb hlwb, qhov kev cog lus no yuav qhib peb lub peev xwm kev txawj ntse. Tsis tas li ntawd, 7,8-dihydroxyflavone cuam tshuam nrog lub paj hlwb serotonin receptors, uas koom nrog hauv kev tswj hwm kev xav. Los ntawm kev hloov kho cov receptors no, nws tuaj yeem txo cov tsos mob ntawm kev ntxhov siab thiab kev nyuaj siab.

Kev ua haujlwm ntawm 7,8-Dihydroxyflavone
1) Txhim Kho Kev Nco thiab Kev Kawm
2) Txhawb kev kho lub hlwb
7,8-DHF txhawb kev kho cov neurons puas.
3) Ua Neuroprotective
4) Muaj cov nyhuv Antioxidant
5) Muaj cov tshuaj tiv thaiv kab mob
7,8-DHF txo qis kev tso tawm ntawm cov kab mob hauv lub hlwb los ntawm kev thaiv NF-κB.
6) 7,8-DHF muaj kev kho mob muaj zog ntawm Alzheimer's disease, thiab tuaj yeem tiv thaiv kev rog los ntawm kev ua kom cov leeg TrkB.

Daim ntawv thov ntawm 7,8-Dihydroxyflavone
7,8-Dihydroxyflavone (7,8-DHF) yog ib qho tshwm sim flavone nyob rau hauv Godmania aesculifolia, Tridax procumbens, thiab primula ntoo nplooj. Nws tau raug pom los ua lub zog thiab xaiv me me-molecule agonist ntawm tropomyosin receptor kinase B (TrkB) (Kd ≈ 320 nM), lub ntsiab lus qhia receptor ntawm neurotrophin hlwb-derived neurotrophic factor (BDNF). 7,8-DHF yog ob qho tib si ntawm qhov ncauj bioavailable thiab muaj peev xwm nkag mus rau cov ntshav-hlwb barrier. Ib tug prodrug ntawm 7,8-DHF nrog zoo heev txhim kho potency thiab pharmacokinetics, R7, tab tom tsim kho rau Alzheimer tus kab mob…