Khoom npe:Galantamine Hydrobromide
Lwm Lub Npe:Galanthamine hydrobromide; Galantamine HBr; Galanthamine HBr; (4aS,6R,8aS)-4a,5,9,10,11,12-hexahydro-3-methoxy-11-methyl-6H-Benzofuro[3a],3,Hydrobromide
CAS Nr:Xyoo 1953-04-4
Specifications:98.0 ib%
Xim:Dawbhmoov nrog cov yam ntxwv tsw thiab saj
GMO Status: GMO Dawb
Ntim: hauv 25kgs fiber ntau nruas
Cia: Khaws lub thawv tsis qhib hauv qhov chaw txias, qhuav, Khaws kom deb ntawm lub teeb muaj zog
Lub neej txee: 24 lub hlis txij li hnub tsim khoom
Galantamine yog siv rau kev kho mob ntawm me me mus rau nruab nrab Alzheimer's kab mob thiab ntau yam kev nco, tshwj xeeb tshaj yog cov keeb kwm vascular. Nws yog ib qho alkaloid uas tau txais los yog los ntawm qhov muag teev thiab paj ntawm Galanthus Caucasicus (Caucasian snowdrop, Voronov's snowdrop), Galanthus woronowii (Amaryllidaceae) thiab lwm yam genera xws li Narcissus (daffodil)), Leucojum (dawb lias corona), Liab Kab laug sab Lily).
Galanthamine yog ntuj muab rho tawm los ntawm lycoris radiate, yog tertiary alkaloid derived los ntawm cov daus poob thiab ze ze cov tsiaj. Nws ua raws li kev sib tw rov qab los ntawm kev sib tw acetylcholinesterase (ACHE) inhibitor, thaum ua tsis muaj zog ntawm butyrylcholinesterse (BuChE). dawb mus yuav luag dawb hmoov; sparingly soluble hauv dej; insoluble chloroform, ether thiab cawv.
Galantamine hydrobromide yog benzazepine muab los ntawm cov qij thiab paj ntawm narcissus, osmanthus, lossis canna. Nws kuj yog ib qho tshuaj cholinesterase inhibitor hauv qhov ncauj. Raws li ib qho ligand rau nicotinic acetylcholine receptors, nws tau siv dav los txhim kho kev paub txog kev ua haujlwm. Nws txoj haujlwm yog kev sib tw thiab thim rov qab inhibit acetylcholinesterase, yog li ua kom cov concentration ntawm acetylcholine. Thaum nqus tau rau hauv cov hlab ntsha, galantamine hydrobromide tau nkag mus rau hauv ntau qhov chaw ntawm lub cev, suav nrog lub hlwb. Nws khi rau nicotinic acetylcholine receptors, ua rau muaj kev hloov pauv thiab nce acetylcholine tso tawm. Nws kuj ua haujlwm los ntawm kev sib tw nrog thiab thim rov qab cov teebmeem ntawm cholinesterase inhibitors. Los ntawm inhibiting cholinesterase, nws tiv thaiv kev tawg ntawm acetylcholine, yog li nce qib thiab lub sijhawm ntawm qhov muaj zog neurotransmitter. Galantamine kuj tseem tuaj yeem txhim kho kev kawm thiab kev nco, tiv thaiv lub hlwb mob, thiab tswj cov qib siab ntawm cov neurotransmitters los ntawm kev tswj hwm kev ncaj ncees ntawm cov neurons thiab synapses.
Muaj nuj nqi:
(1) Anti-cholinesterase.
(2) Txhawb thiab inhibit acetylcholinesterase, tswj intracephalic nicotine receptor txoj haujlwm.
(3) Kho tus me nyuam tuag tes tuag taw sequelae, sweeny thiab myasthenia gravis pseudoparalytica, thiab lwm yam.
(4) Txhim kho kev paub txog kev ua haujlwm ntawm lub teeb, cov neeg mob Alzheimer mob me me, thiab ncua cov txheej txheem ntawm kev ua haujlwm ntawm lub hlwb.
(5) Txhim kho kev ua haujlwm ntawm cov hlab ntsha thiab cov leeg.
Daim ntawv thov
1. GalanthamineHydrobromidefeem ntau yog siv rau hauv myasthenia gravis, poliovirus quiescent theem thiab sequela, kuj nyob rau hauv polyneuritis, funiculitis thiab sensorimotor teeb meem tshwm sim los ntawm paj hlwb kab mob los yog traumatism;
2. Galanthamine Hydrobromide kuj tseem siv rau hauv Alzheimer's disease, muaj lub luag haujlwm tseem ceeb rau dement thiab dysmnesia tshwm sim los ntawm cov organic hlwb puas.
