Khoom npe:YDL 223C (HBT1) hmoov

Lwm Lub Npe:HBT1, YDL223C

CASNo:489408-02-8

Specifications:99.0 ib%

Xim:Lub teeb daj khoomnrog cov yam ntxwv tsw thiab saj

GMOStatus: GMO Dawb

Ntim: hauv 25kgs fiber ntau nruas

Cia: Khaws lub thawv tsis qhib hauv qhov chaw txias, qhuav, Khaws kom deb ntawm lub teeb muaj zog

Lub neej txee: 24 lub hlis txij li hnub tsim khoom

HBT1 yog ib qho molecule uas tuaj yeem khi rau ib qho chaw tshwj xeeb ntawm AMPA-R protein thaum muaj glutamate, thiab qhov kev khi no pab tswj cov haujlwm ntawm cov protein. AMPA receptors tau nthuav tawm thoob plaws hauv lub hauv nruab nrab lub paj hlwb thiab ua lub luag haujlwm tseem ceeb hauv kev sib txuas lus neuronal, kev hnov ​​​​lus, kev kawm, nco, thiab synaptic plasticity. AMPA receptors yog cov neeg txhawb nqa loj rau excitatory neurotransmission, kho kom haum xeeb sai, sai desensitizing excitation ntawm ntau synapses, thiab koom nrog cov lus teb ntxov rau glutamate hauv thaj tsam synaptic. AMPA receptors feem ntau qhia nrog NMDA receptors ntawm synapses, thiab ua ke lawv txhawb cov txheej txheem synaptic plasticity koom nrog hauv kev kawm, nco, excitotoxicity, thiab neuroprotection. Brain-derived neurotrophic factor (BDNF) yog ib qho tseem ceeb ntawm neurotrophic uas ua lub luag haujlwm tseem ceeb hauv kev saib xyuas thiab nthuav dav ntawm cov neurons thiab muaj zog thiab ntau yam cuam tshuam rau kev loj hlob, sib txawv, ciaj sia taus thiab tuag ntawm cov hlwb thiab tsis yog neuronal. , ib qho neurotransmitter modulator uas txhawb nqa neuronal plasticity hauv kev kawm thiab kev nco. Yog li ntawd, nws yog ib qho tseem ceeb rau kev noj qab haus huv thiab kev noj qab haus huv ntawm lub paj hlwb.

Muaj nuj nqi:

1. Poov xab genomic knockout hom
   2. Shmoo tip protein, substrate ntawm Hub1p ubiquitin-zoo li protein; Cov mutants muaj qhov tsis zoo rau mating projection tsim, yog li
   implicating Hbt1p hauv polarized cell morphogenesis; HBT1 muaj paralog, YNL195C, uas tshwm sim los ntawm tag nrho cov genome duplication
   3. Siv rau hauv kev lag luam tshuaj.
   4. Txhim kho kev puas siab puas ntsws.
   5. Txhim kho kev nco thiab leaning peev xwm.
   6. Txhim khu kev txhawb siab.
   7. Txhim khu kev tswj ntawm cortical/subcortical hlwb mechanism.
   8. Txhim kho qhov kev nkag siab zoo.
   9. Txhim kho lub hlwb kom daws tau cov teeb meem thiab tiv thaiv nws los ntawm txhua yam tshuaj los yog lub cev.

Daim ntawv thov:

HBT1 yog ib qho tshiab muaj zog AMPA-R [alpha-amino-3-hydroxy-5-methyl-4-isoxazole-propionic acid (AMPA) receptor] potentiator nrog qis agonistic nyhuv piv nrog LY451395 thiab OXP1, nws induces zus tau tej cov hlwb-derived. neurotrophic yam (BDNF) thiab nthuav tawm me ntsis agonistic nyhuv hauv thawj cov neurons. HBT1 khi rau ligand-binding domain ntawm AMPA-R hauv glutamate dependent manner