Aha ngwaahịa:CMS121

Aha ndị ọzọ: CMS-121;

1,2-Benzenediol,4-[4- (cyclopentyloxy) -2-quinolinyl] -;

4- (4- (cyclopentyloxy) quinolin-2-yl) benzene-1,2-diol (CMS121);

ACC, AcetylCoenzymeACarboxylase, ọrịa, neuroprotective, igbochi, mgbochi mkpali, mitochondrial, Alzheimer's, antioxidant, acetylation, inhibitor, H3K9, Acetyl-CoACarboxylase, CMS121, dementia, ACC1, CMS-121

Ọ BỤGHỊ:1353224-53-9

Nyocha: 98.0% nkeji

Agba: ntụ ntụ edo edo

Mbukota: 25kg/DRUMS

4- (4- (cyclopentyloxy) quinolin-2-yl) benzene-1,2-diol bụ ihe a na-akpọkwa CMS121. Mgbagwoju anya nhazi nke ogige ahụ na-egosi na ọ nwere ike ịnwe akụrụngwa pụrụ iche yana ojiji enwere ike. Iji ghọta mkpa ọ dị, ọ na-enyere aka ịchọpụta otu ndị na-arụ ọrụ na-eweta na nyochaa mmetụta ha nwere ike ime

CMS121 bụ quin oline nọchiri anya nke nwere neuroprotective, mgbochi mkpali, antioxidative, na arụrụ arụ ọrụ. Ọ na-edobe ọkwa glutathione (GSH) na HT22 mouse hippocampal cell in vitro na ọnụnọ nke glutamate, na-ebute ọdịiche nke mkpụrụ ndụ PC12, na-egbochi LPS-induced N9 microglial activation site na 82% na N9 microglia, na-ewepụkwa radicals free na ọrụ Trolox kwekọrọ. (TEAC) nyocha. CMS121 na-echebe megide ischemia na oxytosis na phenotypic screens na HT22 cell in vitro na EC50 ụkpụrụ nke 7 na 200 nM maka igbochi iodoacetic acid- ma ọ bụ glutamate-induced cell ọnwụ, n'otu n'otu. Ọ bụkwa renoprotective, na-ebelata mbelata akụrụ ma na-ebelata nkwupụta nke TNF-α, caspase-1, na inducible nit ric oxi de synthase (iNOS) na ụdị òké SAMP8 nke ọrịa akụrụ na-adịghị ala ala jikọtara ya na ịka nká ngwa ngwa mgbe a na-enye ya na dose. nke 10 mg / kg kwa ụbọchị malite na ọnwa itoolu.

4- (4- (cyclopentyloxy) quinolin-2-yl) benzene-1,2-diol bụ ihe a na-akpọkwa CMS121. Mgbagwoju anya nhazi nke ogige ahụ na-egosi na ọ nwere ike ịnwe akụrụngwa pụrụ iche yana ojiji enwere ike. Iji ghọta mkpa ọ dị, ọ na-enyere aka ịchọpụta otu ndị na-arụ ọrụ dị ugbu a na nyochaa mmetụta ha nwere ike ime. Ọnụnọ nke mgbanaka quinoline na-egosi na ogige ahụ nwere ike ịdị na-arụ ọrụ nke ndụ. A maara ụmụ irighiri ihe ndị sitere na Quinoline maka ihe ndị dị ndụ ha dị iche iche, gụnyere ihe na-egbu egbu na mgbochi mkpali. Mgbakwunye nke otu cyclopentyloxy nwere ike inye aka na solubility nke ogige ma ọ bụ kwalite ọrụ ndu ya site na mmetụta dị egwu. N'ime ọmụmụ ihe na mkpụrụ ndụ HT22, CMS-121 egosipụtawo mmetụta neuroprotective dị ịrịba ama, na-echebe mkpụrụ ndụ ndị a nke ọma site na ischemia na mmebi oxidative. Ọzọkwa, CMS-121 nwere mmetụta mgbochi mkpali dị ịrịba ama, na-egosi ikike ọ nwere imezi nzaghachi mkpali. Site n'ime nke a, CMS-121 nwere ike ibelata mbufụt na anụ ahụ na akụkụ dị iche iche. CMS-121 nwere ọrụ ọgwụ siri ike dị ka onye na-egbochi acetyl-CoA carboxylase 1 (ACC1). Mmetụta mgbochi ya nwere ike na ACC1 na-eme ka ọ bụrụ ihe na-ekwe nkwa

Ngwa:

CMS-121 (CMS121) bụ akwụkwọ akụkọ na ike sitere na fisetin nwere mgbochi ịka nká, neuroprotective, mgbochi mkpali, antioxidative na renoprotective. inhibitor na-ekwe nkwa pharmacological Njirimara. Emere nyocha sara mbara iji nyochaa uru CMS-121 nwere ike na mpaghara dị iche iche, gụnyere neuroprotection, mmetụta mgbochi mkpali, ọrụ antioxidant, na mmetụta ya na akara ndị metụtara ịka nká.