Arachidonoyl Ethanolamide, arachidonoylethanolamide, N-arachidonoylethanolamine, ndi AEA zonse ndizofanana ndi anandamide yokha.Mwa njira, (5Z,8Z,11Z,14Z)-N-(2-hydroxyethyl)icosa-5,8,11,14-tetraenamide ndi dzina la mankhwala la anandamide (dzina la IUPAC) ndipo litha kugwiritsidwa ntchito m'mabuku asayansi okha.Komabe, 94421-68-8 ndi ID yake yapadera yamankhwala (CAS Registry Number).Popeza AEA ndi nthawi yaifupi kwambiri ya anandamide, titha kugwiritsa ntchito AEA pafupipafupi kunena za anandamide m'malemba ndi zithunzi zotsatirazi.
Dzina lazogulitsa:ZochulukaAnandamide powder
Mawu ofanana: Arachidonoyl Ethanolamide, AEA powder, arachidonoylethanolamide, (5Z,8Z,11Z,14Z)-N-(2-hydroxyethyl)icosa-5,8,11,14-tetraenamide,N-arachidonoylethanolamine
Nambala ya CAS: 94421-68-8
Chomera Chogwiritsidwa Ntchito: Tsamba
Zosakaniza: Apigenin
Mafuta a AEA: 90%
AEA ufa: 50%
Mtundu:Yellow powder
mafuta achikasu-bulauni
Kulongedza: mu 25kgs fiber ng'oma
Kusungirako: Sungani chidebe chosatsegulidwa pamalo ozizira, owuma, Khalani kutali ndi kuwala kwamphamvu
Shelf Life: Miyezi 24 kuyambira tsiku lopangidwa
Malinga ndi Wikipedia, anandamide ndizomwe zimachitika cannabinoid neurotransmitter muubongo, zomwe zikutanthauza kuti ubongo wamunthu umatha kupanga anandamide popanda kudya zakudya zomwe zili ndi AEA.Ubongo wamitundu yoyamwitsa ndi cacao yaiwisi amatsimikiziridwa kuti ali ndi kuchuluka kwa anandamide.
Zakudya za anandamide
Palibe magwero ambiri achindunji a anandamide, ndipo chokoleti ndi ma truffles zili pamwamba pawo.Truffle ndiyokwera mtengo kwambiri kupeza anandamide, ndipo chokoleti ikuwoneka kuti ndiye gwero lodalirika lazakudya zambiri zokhazikika.
Anandamidendi chokoleti
Nyemba za kakao, gwero la chokoleti, ndi gwero lambiri la anandamide.Mu chokoleti muli zinthu zopitilira 300.Caffeine, theobromine, ndi phenylethylamine ndizomwe zimadziwika zomwe zimakweza malingaliro athu.Theobromine kwenikweni imathandizira kulimbikitsa ubongo kutulutsa anandamide yochulukirapo kutipangitsa kukhala osangalala.
Chifukwa chiyani anandamide ikukula kwambiri m'zaka zaposachedwa?
Tisanayankhe funsoli, tiyenera kutchula chamba, THC & CBD (Cannabidiol) poyamba.
Chamba, chomwe chimadziwikanso kuti chamba, ndi chomera chamaluwa, ndipo anthu amachigwiritsa ntchito ngati mankhwala aphwando kapena amasuta kuti apange "mmwamba" kapena "woponyedwa miyala".
Zomwe zimagwiritsidwa ntchito mu chamba zomwe zimakupangitsani kukhala okwera ndi THC, yokhala ndi dzina lonse ngati delta 9-Tetrahydrocannabinol.Anthu akamasuta chamba, tetrahydrocannabinol mu chamba imalimbikitsa cholandilira chamba, kupangitsa anthu kukhala osangalala komanso oganiza bwino.
Chamba ndi choletsedwa m'maiko ambiri chifukwa anthu ambiri amachikonda.
Komabe, Uruguay ndi dziko loyamba kulembetsa cannabis mchaka cha 2013.
Pa Oct 17, 2018, boma la Canada lidalengeza kuti cannabis ikhale yovomerezeka ku Canada konse.
Ku United States, maiko 10 ndi District of Columbia avomereza kugwiritsa ntchito chamba posangalala ngakhale kuti sikuloledwa ndi boma.
Anandamide vs THC
Chamba ndi chomera cha THC.
Anandamide ndiye mtundu wamunthu wa THC.
Asayansi adapeza AEA mu 1992 ndi THC mu 1964.
Anandamide imatulutsa mankhwala olimbikitsa kusinthasintha kuchokera muubongo, ndipo kachitidwe kake kachilengedwe kamafanana ndi tetrahydrocannabinol mu chamba.
Inde, amayang'ana ma cannabis receptor omwewo, ndipo tikambirana za makina a AEA posachedwa.
Komabe, mphamvu ya THC ndi yamphamvu kwambiri kuposa AEA.Kumverera kotenga AEA sikosangalatsa kuposa kusuta chamba popeza anandamide imapangidwa mwachangu m'thupi, mwina mkati mwa mphindi 30.
Popeza cannabis ndiyoletsedwa m'maiko ambiri, zowonjezera, zakudya, zakumwa kapena zodzikongoletsera zomwe zili ndi THC ndizosaloledwa.M'lingaliro limeneli, anandamide ndi tsogolo.
Anandamide vs CBD
Chomera cha chamba chili ndi 400+ mankhwala, ndipo zopitilira 60 zosiyanasiyana cannabinoids zimamangiriza ku zolandilira m'thupi lathu.
CBD ndi mtundu waufupi wa cannabidiol ndipo ndi amodzi mwa 60 cannabinoids.CBD ndi phytocannabinoid mu cannabis.Zoposa 40% za cannabis zotulutsa ndi CBD.
Asayansi ndi madotolo adapeza kuti CBD imatha kukweza mulingo wa anandamide mu synapses yaubongo ngati chowonjezera cha anandamide komanso choletsa kuwononga.Mafuta acid amide hydrolase, omwe amadziwikanso kuti FAAH mwachidule, ndi puloteni yomwe imaphwanya AEA.Umu ndi momwe CBD imalepheretsa FAAH ndikuwongolera AEA mwachilengedwe.
CBD imatha kuchita zambiri kuposa izi.CBD ikhoza kukhala yopindulitsa ku Endocannabinoid System yonse
Njira ya zochita za anandamide
Kodi anandamide imagwira ntchito bwanji?Ndizovuta ndithu.Muyenera kudziwa kaye za endocannabinoid system, cholandilira cha CB1, ndi cholandilira cha CB2.
CB1
THC ili ndi kuyanjana kwakukulu kwa cholandilira cha CB1, chogwirizana kwambiri ndi cholandirira.
Kuphatikiza apo, anandamide imakhudza kumverera "kwapamwamba" pokhudza cholandilira cha CB1, kuyambitsa dongosolo la mphotho muubongo ndikupanga mankhwala osangalatsa monga dopamine Hormone.
CB2
Mutha kupeza zolandilira CB2 m'maselo oteteza chitetezo mthupi lanu lonse.CB2 receptor imayang'anira mayankho a neuroprotective ndikulimbana ndi kutupa.Asayansi amakhulupirira kuti cholandilira cha CB2 ndichothandiza pakuchepetsa ululu.
Ma CB1 receptors amakhazikika makamaka muubongo ndi CNS system, pomwe ma CB2 receptors amapezeka makamaka mu chitetezo chamthupi.
Endocannabinoid System (ECS)
Musanayambe kukambirana za ntchito za endocannabinoid system (ECS), ndikofunikira kumvetsetsa zigawo zake.ECS imapangidwa ndi cannabinoid zolandilira, endogenous ligands (kumanga mamolekyu) kwa zolandilirazo, ndi michere yomwe imapanga ndikuyipitsa ligand.
| Mtengo wapatali wa magawo ECS | Kusintha kwa mtengo wa ECS | |
| cannabinoid receptors | CB1, CB2 | PPAR, GPR, TRPV, FLAT, FABP |
| endogenous ligands | AEA, 2-AG | OEA,PEA,2-AGE,NADA,VA,EPEA,SEA,OA,DHEA |
| Ma enzymes amawononga ligand | PA, MAGL | ABHD6,COX-2,ABHD12 |
| Ma enzymes opangira ma ligands | DAGL,NAT,NAPE-PLD | SHIP1, PTPN22,PLC,GDEI,ABHD4 |
bwalo lamkati (loyera) limayimira 'classical' endocannabinoid system.Bwalo lakunja (lotuwa) limaphatikizapo zigawo za dongosolo la endocannabinoid.Monga mukuwonera, PEA, SEA, ndi OEA akuphatikizidwanso mu endocannabinoid system.
Ma EC ali ndi chiyambi chapakati cha mitsempha (CNS) ndipo akuphatikizapo anandamide (AEA), 2-arachidonoylglycerol (2-AG), noladin ether, virodhamine ndi N-arachidonylodopamine (NADA).Ndipo anandamide ndiye ligand yoyamba komanso yofunika kwambiri mu endocannabinoid system.
Anandamide ndi 2-AG
Monga tafotokozera pamwambapa, anandamide (AEA) ndi 2-arachidonoylglycerol (2-AG) ndi ma ligand awiri oyambirira mu dongosolo la ECS.ECS imathandiza kuyendetsa ntchito monga kugona, chitetezo cha mthupi, ndi kusintha kwa ululu.
Asayansi adapeza Anandamide mchaka cha 1992 ndi 2-AG 3 zaka pambuyo pake.AEA ndi 2-AG ali ndi mawonekedwe ofanana kwambiri a mamolekyu motero amafanana ndi thupi ndi mankhwala.
Anandamide imayang'ana kwambiri cholandirira CB1 muubongo, pomwe 2-AG imayang'ana onse CB1 ndi CB2 receptors (mu chitetezo chamthupi).
Onse Anandamide ndi 2-AG amapangidwa kuchokera ku arachidonic acid, Omega-6 mafuta acid, okhala ndi njira zosiyanasiyana komanso kupanga ma enzyme.Kusokoneza enzyme FAAH (Fatty Acid Amide Hydrolase) kwa AEA ndi 2-AG ndi MAGL enzyme (Monoacylglycerol Lipase).
Ubwino wa Anandamide
Umboni wa sayansi umasonyeza kuti anandamide ikhoza kukhala yabwino kudana ndi nkhawa, thanzi labwino, kukumbukira kukumbukira, kuchepetsa chilakolako, kuchepetsa ululu, neuroprotection, ndi zina.
Anandamide ndi nkhawa
Anthu amatcha Anandamide "mamolekyu achisangalalo" chifukwa AEA imatha kukupangitsani kukhala osangalala.
Umboni wosintha ukuwonetsa kuti dongosolo la endocannabinoid ndi gawo lofunikira la magawo a neuronal omwe amakhudzidwa ndi njira za mphotho zaubongo komanso kuyankha kwamalingaliro pakupsinjika.
Pharmacological blockade ya enzyme fatty acid amide hydrolase (FAAH), yomwe imayambitsa kuwonongeka kwa anandamide m'kati mwa maselo, imatulutsa zowawa ngati makoswe popanda kuchititsa kuyankha kosiyanasiyana kwa machitidwe omwe amachita mwachindunji cannabinoid agonists.
Zotsatirazi zikusonyeza kuti anandamide imathandizira kuwongolera malingaliro ndi nkhawa komanso kuti FAAH ikhoza kukhala chandamale cha gulu lakale la mankhwala oda nkhawa.
Kuti mumve zambiri za zotsatira za anandamide pa nkhawa, chonde werengani zolemba pansipa:
- The endogenous cannabinoid anandamide imakhala ndi zolimbikitsa komanso nkhawa zomwe zimawululidwa ndi kuletsa kwamafuta acid amide hydrolase (FAAH).
- Anandamide hydrolysis: chandamale chatsopano chamankhwala odana ndi nkhawa?
- Kuchepetsa khalidwe lokhala ngati nkhawa lomwe limayambitsidwa ndi kuletsa kwa majini ndi mankhwala a endocannabinoid-degrading enzyme fatty acid amide hydrolase (FAAH) imayanjanitsidwa ndi CB1 receptors.
Anandamide ndi kuchepetsa ululu
ome umboni wa sayansi umasonyeza kuti kulepheretsa FAAH (enzyme yomwe imasokoneza anandamide mu ubongo) inachepetsa kwambiri mayankho a nociceptive mu zitsanzo zambiri zowawa.
FAAH inhibitors imakulitsa kwambiri milingo ya anandamide muubongo ndipo makamaka imapangitsa CB1receptor-mediated antinociception, kutanthauza kuti endogenous anandamide, ikatetezedwa kuti isawonongeke, imatha kupanga antinociception kudzera mu CB.1ma receptors.
Palmitoylethanolamide (PEA) ndi chinthu chokhazikika chomwe chimathandizira ntchito ya anandamide.Thupi la munthu mwachibadwa limapereka PEA kulimbana ndi kutupa ndi ululu.Odwala oposa 800,000 akhala mapiritsi a PEA ndi zakudya zowonjezera kuti athetse ululu padziko lapansi.
Kuti mudziwe zambiri za PEA, chonde pitani kwathuTsamba la PEA.
Anandamide ndi wothamanga kwambiri
Tiyeni tiyang'ane kaye tanthauzo la kukwera kwa wothamanga: kumverera kwa chisangalalo ndi nkhawa yocheperako komanso kusamva kupweteka.Pambuyo pakuchita masewera olimbitsa thupi kwa nthawi yayitali, mudzakhala ndi chodabwitsa chotere panthawi yayitali.
M'zaka makumi angapo zapitazi, ofufuza adaganiza kuti endorphin ndiye chinthu chokhacho chomwe chimachititsa othamanga kwambiri popeza kuchuluka kwa ma β-endorphin kumapezeka mosavuta m'magazi.Monga mukudziwira kale, endorphin imatha kukulitsa malingaliro athu ndikupanga kumverera kosangalatsa.
Komabe, asayansi tsopano akukhulupirira kuti ndi endocannabinoid system (ECS) ndi anandamide zomwe zimapangitsa wothamanga kukhala wokwera.Anandamide amatha kuwoloka chotchinga chamagazi-muubongo ndikupereka zotsatira zapakati za ma opioid otumphukira.Koma endorphin sangathe.
Ngati mukufuna kudziwa za kuyesa kwa runner's high, werengani zolemba izi:Kukwera kwa wothamanga kumadalira ma cannabinoid receptors mu mbewa
Akatswiri azakudya amapeza kuti anandamide ikhoza kukhalanso yowongolera chikhumbo.Anandamide ikhoza kudzutsa njala yanu komanso chikhumbo chofuna kudya kwambiri.Ngati muli panjira yochepetsera thupi, ganizirani mosamala musanatenge AEA.
Zowonjezera zomwe zili ndi anandamide
Kodi mukuyang'ana zowonjezera za anandamide kapena mapiritsi a anandamide?
Tsoka ilo, palibe pakadali pano.Anandamide ndichinthu chatsopano kwambiri kotero kuti palibe zakudya zowonjezerapo zomwe zidayesapo m'njira zomwe zilipo.
Mutha kupeza kampani yotchedwa Sun Potion ikugulitsa ufa wa anandamide pa Amazon.Komabe, zimenezo si zoona.Ndi ufa wa cacao waiwisi, koma osati wokhazikika wa anandamide.Ndipo zomwe zimagwira mu mawonekedwe a ufa ndizochepa kwambiri, ndipo simungakumane ndi mphamvu za AEA.
Zachidziwikire, mutha kupeza kuti ena ogulitsa akugulitsa zolozera za anandamide kapena ma reagents.Choyipa ndichakuti amangogulitsa pa 5mg, 25mg, komanso pakufufuza kokha.Palibe zambiri zamafuta a AEA zomwe zikupezeka konse.
Nkhani yabwino ndiyakuti opanga zowonjezera ku United States ndi mayiko aku Europe monga Germany, France, Netherland, UK, Spain, Italy, etc. akuyitanitsa zitsanzo za AEA kuchokera ku Wuxi Cima Science Co., Ltd, ndipo kupanga malonda ambiri kuli mkati. .
Mafotokozedwe a Anandamide
Mafuta ambiri a anandamide ndi ufa wa anandamide onse akupezeka ku Cima Science.
Mafuta a Anandamide: 70%, 90%
Anandamide powder: 50%
