Dzina la malonda:Stearoyl Vanillylamide(SVA）
Dzina Lina:C18-VA, N-Vanillyloctadecanamide,Capsaicin AnalogiCAS Number:58493-50-8
Gwero la Botanical: Piper Longum Linn
Chiwerengero: 98%
Zitsanzo Zaulere: Zilipo
Maonekedwe: woyera mpaka ufa woyera
Ubwino: Anti-cancer, anti-kukalamba, senolytic
Alumali Moyo: 2 years
Stearoyl vanillylamide ndi amodzi mwa ma analogi odziwika bwino a capsaicin ndipo ndi analogi yodziwika bwino ya capsaicin yomwe imapezeka mumitundu ya tsabola wofiira.Capsaicin ndi chifukwa cha kutentha / kuyaka kutentha chifukwa cha tsabola.Mosiyana ndi mitundu ina ya capsaicin yomwe ili m'gulu lomwelo, Stearoyl vanillylamide ndi yapadera chifukwa si steroidal, kutanthauza kuti samatulutsa "zokometsera" kapena zokhumudwitsa za capsaicin.
Nthawi zambiri, monga ma analogi ena a capsaicin, mankhwalawa amagwira ntchito popititsa patsogolo kutulutsidwa kwa epinephrine ndi norepinephrine.Ma mahomoniwa amafunikira kuti ayambitse machitidwe osiyanasiyana amthupi achifundo monga metabolism.Chifukwa chake, stearoyl vanillylamide pamapeto pake imathandizira kuwotcha mafuta a bulauni mu minofu ya adipose kapena minofu yocheperako.
Kodi maubwino ogwiritsira ntchito Stearoyl Vanillylamide ndi chiyani?Kuphatikizika kwa stearic acid amide kuli ndi maubwino angapo pokonzekera zowonjezera zaumoyo.Pomwe maphunziro ambiri akupitilirabe, asayansi akuyembekezera kupeza zabwino zambiri zogwiritsa ntchito mankhwalawa.Zotsatirazi ndi zina mwazabwino zomwe zimadziwika pogwiritsa ntchito Stearoyl vanillylamide:
Imaphwanya bwino mafuta am'mimba
Stearoyl vanillylamide imakhala ngati capsaicin yosakwiyitsa yomwe imatha kuyambitsa minofu ya bulauni kapena mafuta abulauni (mafuta amapezeka makamaka mu mitochondria ndipo amatulutsa kutentha m'thupi).Mafuta amapezeka m'zigawo zonse za thupi, kuphatikizapo mikono, ntchafu, mimba ndi gluteal minofu.Ngakhale kuti anthu ambiri amatha kuchotsa mwamsanga mafuta m'madera ena, kuwotcha mafuta a m'mimba kumaonedwa kuti ndi katundu weniweni.Kafukufuku wasonyeza kuti kutenga Stearoyl vanillylamide kungathandize kuthetsa mafuta omwe ali makamaka pamimba.Izi zimatheka poyambitsa TRPV1, puloteni yomwe imalepheretsa kupanga mafuta m'mimba ndi kupanga mafuta.Pamodzi ndi capsaicin, Stearoyl vanillylamide imaonedwa kuti ndi imodzi mwazinthu zomwe zimayang'ana ndi kuyambitsa TRPV1 (zosakhalitsa zolandirira zomwe zingatheke vanilloid) zomwe zili mu membrane ya plasma (kupatulapo ma ligands amkati, oyimira pakati otupa komanso zolimbikitsa zosasankha).Udindo woyika puloteni wa membrane wofunikira ngati njira ya ion.Pamene TRPV1 imayendetsedwa makamaka pazitsulo zomveka ndi maselo osakhala a neuronal, zidzachititsa kuti calcium ndi sodium ikhale yochuluka, zomwe ndizofunikira kuti membrane depolarization (kusintha kwa polarity; kuchoka ku zoipa kupita ku zabwino, zomwe zimatsogolera ku zotsatira zabwino) Maselo a cell ndi ake. kulankhulana.
Imaphwanya bwino mafuta am'mimba
Stearoyl vanillylamide imakhala ngati capsaicin yosakwiyitsa yomwe imatha kuyambitsa minofu ya bulauni kapena mafuta abulauni (mafuta amapezeka makamaka mu mitochondria ndipo amatulutsa kutentha m'thupi).Mafuta amapezeka m'zigawo zonse za thupi, kuphatikizapo mikono, ntchafu, mimba ndi gluteal minofu.Ngakhale kuti anthu ambiri amatha kuchotsa mwamsanga mafuta m'madera ena, kuwotcha mafuta a m'mimba kumaonedwa kuti ndi katundu weniweni.Kafukufuku wasonyeza kuti kutenga Stearoyl vanillylamide kungathandize kuthetsa mafuta omwe ali makamaka pamimba.Izi zimatheka poyambitsa TRPV1, puloteni yomwe imalepheretsa kupanga mafuta m'mimba ndi kupanga mafuta.Pamodzi ndi capsaicin, Stearoyl vanillylamide imaonedwa kuti ndi imodzi mwazinthu zomwe zimayang'ana ndi kuyambitsa TRPV1 (zosakhalitsa zolandirira zomwe zingatheke vanilloid) zomwe zili mu membrane ya plasma (kupatulapo ma ligands amkati, oyimira pakati otupa komanso zolimbikitsa zosasankha).Udindo woyika puloteni wa membrane wofunikira ngati njira ya ion.Pamene TRPV1 imayendetsedwa makamaka pazitsulo zomveka ndi maselo osakhala a neuronal, zidzachititsa kuti calcium ndi sodium ikhale yochuluka, zomwe ndizofunikira kuti membrane depolarization (kusintha kwa polarity; kuchoka ku zoipa kupita ku zabwino, zomwe zimatsogolera ku zotsatira zabwino) Maselo a cell ndi ake. kulankhulana.
