Dzina lazogulitsa:Lupeol Powder98%
Gwero la Botanic:Mango, Acacia visco, Abronia villosa, Dandelion coffee.
CASNo:545-47-1
Mtundu:Zoyera mpaka zoyeraufa ndi khalidwe fungo ndi kukoma
Kufotokozera:≥98% HPLC
Mtengo wa GMOMkhalidwe: GMO Yaulere
Kulongedza: mu 25kgs fiber ng'oma
Kusungirako: Sungani chidebe chosatsegulidwa pamalo ozizira, owuma, Khalani kutali ndi kuwala kwamphamvu
Shelf Life: Miyezi 24 kuyambira tsiku lopangidwa
Zochitika Zachilengedwe:
Lupeol (Clerodol; Monogynol B; Fagarasterol) ndi pentacyclic triterpenoid yogwira, imakhala ndi anti-oxidant, anti-mutagenic, anti-tumor ndi anti-inflammatory action.Lupeol ndi wamphamvuandrogen receptor(AR) inhibitor ndipo ingagwiritsidwe ntchitokhansakufufuza, makamaka prostatekhansaya phenotype yodalira androgen (ADPC) ndi phenotype yosagwirizana ndi castration (CRPC) [1].
Mu Vitro Kafukufuku:
Lupeol ndi AR inhibitor yamphamvu yomwe imatha kupangidwa ngati mankhwala omwe angathe kuchiza khansa ya prostate (CaP).Chithandizo cha Lupeol (10-50 μM) cha 48 h chinapangitsa kuti kukula kodalira mlingo kulepheretsa maselo a phenotype (ADPC), omwe ndi LAPC4 ndi LNCaP maselo, ndi IC50 ya 15.9 ndi 17.3 μM, motsatira.Lupeol idalepheretsanso kukula kwa 22Rν_1 ndi IC50 ya 19.1 μM.Kuphatikiza apo, Lupeol inaletsa kukula kwa maselo a C4-2b ndi IC50 ya 25 μM.Lupeol imatha kuletsa kukula kwa ma cell a CaP a ADPC ndi CRPC phenotypes.Androgens amadziwika kuti amayendetsa kukula kwa ma cell a CaP kudzera mu kuyambitsa kwa AR[1]
Kafukufuku wa Vivo:
Lupeol ndi mankhwala ogwira mtima omwe amatha kuletsa kukula kwa maselo a CaP mu vivo.Miyezo yonse yozungulira ya seramu ya PSA (yobisika ndi maselo otupa opangidwa ndi chotupa) idayesedwa kumapeto kwa phunzirolo pa tsiku la 56. Patsiku la 56 pambuyo pa kuikidwa, milingo ya PSA kuyambira 11.95-12.79 ng / mL idawonedwa munyama zowongolera ndi zotupa za LNCaP ndi C4-2b zotupa, motero.Komabe, anzawo omwe amathandizidwa ndi Lupeol adawonetsa kuchepa kwa seramu PSA kuyambira 4.25-7.09 ng/mL.Zotupa zochokera ku nyama zothandizidwa ndi Lupeol zimawonetsa kuchepa kwa seramu ya PSA poyerekeza ndi zowongolera[1]
