Dzina la malonda: Celastrol bulk powder

Gwero la Botanic:The God Vine(Tripterygium wilfordii hook.f)

CASNo:34157-83-0

Utoto: ufa wofiyira wonyezimira wa kristalo wokhala ndi fungo labwino komanso kukoma kwake

Kufotokozera:≥98% HPLC

Mtengo wa GMOMkhalidwe: GMO Yaulere

Kulongedza: mu 25kgs fiber ng'oma

Kusungirako: Sungani chidebe chosatsegulidwa pamalo ozizira, owuma, Khalani kutali ndi kuwala kwamphamvu

Shelf Life: Miyezi 24 kuyambira tsiku lopangidwa

Celastrol Powderndizomwe zimagwira ntchito mu Tripterygii Radix, yomwe ndi muzu wouma ndi rhizome ya Mulungu Vine.Pali mitundu inayi yonse, ndiyoTripterygium wilfordii Hook.f, Tripterygium hypoglaucum Hutch, Tripterygium regelii Sprague et Takeda, ndi Tripterygium forresti Dicls.

Diterpenoids: triptolide(cas no.38748-32-2), Tripdiolide(cas no.38647-10-8), etc.

Triterpenoids: Celastrol(cas no.34157-83-0), Wilforlide A(cas no.84104-71-2), etc.

Alkaloids:Wilforgine(cas no.37239-47-7), Wolverine (cas no.11088-09-8), wilforidine, etc.

Tripterygium ndi pentazine triterpene yomwe imapezeka mwachilengedwe ku Tripterygium wilfordii.Ndiwothandiza pochiza nyamakazi.Triptolide imalepheretsa proteasome ndi nuclear factor Kb kugwira ntchito.

Celastrol (Tripterin) ndi proteasome inhibitor yokhala ndi anti-yotupa komanso antioxidant ntchito.Imalepheretsa mogwira mtima komanso mwamakonda ntchito ngati chymotrypsin ya 20S proteasome yokhala ndi IC50 ya 2.5 μM.

Tripterine ndi antioxidant wamphamvu komanso anti-inflammatory agent.Ndi HSP90 inhibitor yatsopano (kusokoneza Hsp90 / Cdc37 complex), imakhala ndi zotsatira zotsutsana ndi khansa (anti-angiogenesis - imalepheretsa vascular endothelial growth factor receptor expression);antioxidant (amaletsa lipid peroxidation) ndi anti-yotupa ntchito (Imalepheretsa kupanga iNOS ndi kutupa kwa cytokines)

BiologicalAntchito:

Celastrol (Tripterin) pansi-imayang'anira basal ndi DNA-owononga wothandizira-omwe amachititsa FANCD2 monoubiquitination, ndikutsatiridwa ndi kuwonongeka kwa mapuloteni.Chithandizo cha Celastrol chimachotsa poyang'ana IR-induced G2 ndikuwonjezera kuwonongeka kwa DNA komwe kumayambitsa mankhwala a ICL ndi zotsatira zolepheretsa maselo a khansa ya m'mapapo pochotsa FANCD2.Celastrol imakhala ndi zoletsa komanso zoyambitsa ma apoptosis pama cell a DU145 opangidwa mu vitro munthawi yake komanso motengera mlingo.Celastrol's anti-prostate cancer zotsatira mwina ndi kutsika-kuwongolera kuchuluka kwa mayendedwe a hERG m'maselo a DU145, kutanthauza kuti Celastrol atha kukhala mankhwala oletsa khansa ya prostate, ndipo njira yake ikhoza kukhala yotsekereza njira za hERG.Celastrol imathandizira colitis yoyeserera mu mbewa zoperewera za IL-10 poletsa njira yolumikizira PI3K/Akt/mTOR ndikuwongolera autophagy.Celastrol imatha kuletsa ntchito ya cytochrome P450 ndipo imatha kuyambitsa kuyanjana kwazitsamba.Celastrol imapangitsa apoptosis m'maselo a TNBC, kutanthauza kuti apoptosis ikhoza kulumikizidwa kudzera mu kusagwira ntchito kwa mitochondrial ndi njira yowonetsera PI3K/Akt.Celastrol imapangitsa apoptosis ndi autophagy kupyolera mu njira yowonetsera ROS/JNK.Celastrol imalepheretsa kufa kwa dopaminergic neuron mu matenda a Parkinson poyambitsa mitochondrial apoptosis.

Udindo wa Celastrol mu chemosensitization ya khansa:

Chemotherapy ikadali njira yayikulu yothandizira odwala khansa.Komabe, chithandizo chamankhwala nthawi zambiri chimayenera kuphatikizidwa ndi mankhwala ena kuti achepetse zotsatira zoyipa ndikupewa kukana mankhwala.Mankhwala achilengedwe amagwiritsidwa ntchito mochulukira monga ma adjuvant therapy kuphatikiza ndi ma chemotherapy regimens omwe alipo kuti apititse patsogolo chithandizo chamankhwala.Chitsanzo chimodzi chodalirika cha mankhwala achilengedwe oterowo ndi gulu la triterpene lotchedwa celastrol, lomwe lingakhale ndi kuthekera kwakukulu kogwiritsiridwa ntchito monga chodziŵira mankhwala.Wodziwika koyambirira kuchokera ku Bingu la Mulungu Vine, amawongolera molakwika mamolekyu angapo a oncogenic monga NF-κB, topoisomerase II, Akt/mTOR, HSP90, STAT3, ndi Notch-1.Izi zingayambitse kuyankha kotsutsa-kutupa, kulepheretsa kukula kwa chotupa ndi kupulumuka, ndikuchotsa angiogenesis.Mutuwu ukufotokoza mwachidule ntchito yomwe celastrol ingakhalepo ngati chemosensitizer komanso njira zoyambira zamamolekyu zomwe zimayanjanitsa zomwe zanenedwapo pamakhansa osiyanasiyana.